功能协同化高分子纳米载药系统的疗效及初步安全性评价

51390484
2013
E0308.生物医用有机高分子材料
陈学思
重大项目
研究员
中国科学院长春应用化学研究所
564万元
高分子纳米药物;安全性评价;疗效;抗肿瘤药物;肿瘤微环境
2014-01至2018-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Production and clinical development of nanoparticles for gene delivery 期刊论文 Jie Chen();Zhaopei Guo;Huayu Tian();Xuesi Chen
2 Drug binding rate regulates the properties of polysaccharide prodrugs 期刊论文 Li Di();Ding Jianxun();Zhuang Xiuli;Chen Li();Chen Xuesi
3 Macrophages loaded CpG and GNR-PEI for combination of tumor photothermal therapy and immunotherapy 期刊论文 Chen Jie;Lin Lin;Yan Nan;Hu Yingying;Fang Huapan;Guo Zhaopei;Sun Pingjie;Tian Huayu();Chen Xuesi()
4 Efficient side-chain modification of dextran via base-catalyzed epoxide ring-opening and thiol-ene click chemistry in aqueous media 期刊论文 Mingqiang Li;Zhaohui Tang;Chao Wang;Yu Zhang;Haitao Cui;Xuesi Chen()
5 一种碳酸钙包裹的金纳米棒、其制备方法及应用 专利 田华雨();徐彩娜;王艳兵;陈学思
6 Acid-labile boronate-bridged dextran-bortezomib conjugate with up-regulated hypoxic tumor suppression 期刊论文 Xu Weiguo;Ding Jianxun();Li Lingyu;Xiao Chunsheng;Zhuang Xiuli;Chen Xuesi()
7 Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy 期刊论文 Zhang Yanbo;Ding Jianxun();Sun Diankui;Sun Hai;Zhuang Xiuli;Chang Fei;Wang Jincheng();Chen Xuesi
8 Application of Zwitterionic Polymers in the Treatment of Malignant Tumors 期刊论文 Chen Jie;Li Xiaozhou;Tian Huayu;Zhu Xiaojuan;Chen Xuesi
9 一种改性超支化聚乙烯亚胺、其制备方法及应用 专利 田华雨;郭兆培;陈学思;林琳;陈杰;陈学思
10 Novel pH- and amylase-responsive microgels for oral insulin delivery 会议论文 Liu Liang; He Chaoliang; Zhang Ying; Shi Shun; Zhang Zhen; Chen Xuesi
11 epsilon-Methacryloyl-L-lysine based polypeptides and their thiol-ene click functionalization 期刊论文 Xu Qinghua;He Chaoliang;Xiao Chunsheng;Yu Shuangjiang;Chen Xuesi
12 A facile pH-sensitive shielding strategy for polycationic gene delivery system 会议论文 Guan Xiuwen;Zhang Ying;Tian Huayu();Chen Xuesi
13 Interleukin-15 and cisplatin co-encapsulated thermosensitive polypeptide hydrogels for combined immuno-chemotherapy 期刊论文 Wu Xilong;Wu Yundi;Ye Hongbo;Yu Shuangjiang;He Chaoliang;Chen Xuesi
14 Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer 期刊论文 Xu Caina;Wang Ping;Zhang Jingpeng;Tian Huayu();Park Kinam;Chen Xuesi()
15 Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment 期刊论文 Hecheng Ma;Chaoliang He;Yilong Cheng;Zhiming Yang;Jnuting Zang;Jianguo Liu;Xuesi Chen
16 改性聚乙二醇/碳酸钙复合材料、其制备方法及应用 专利 田华雨;郭兆培;陈学思;林琳;陈杰;关秀文
17 Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin 期刊论文 Song Wantong;Tang Zhaohui();Zhang Dawei;Zhang Ying;Yu Haiyang;Li Mingqiang;Lv Shixian;Sun Hai;Deng Mingxiao;Chen Xuesi
18 Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier 期刊论文 Guo Zhaopei;Tian Huayu;Lin Lin;Chen Jie;He Chaoliang;Tang Zhaohui;Chen Xuesi
19 Engineered nanogel with superior tissue affinity and cell targeting toward orthotopic bladder cancer 会议论文 Guo Hui;Xu Weiguo;Wang Jixue;He Liang;Hou Yuchuan;Ding Jianxun
20 Synergistic treatment of cancer stem cells by combinations of antioncogenes and doxorubicin 期刊论文 Jie Chen();Lin Lin;Zhaopei Guo;Caina Xu;Huayu Tian();Kinam Park;Xuesi Chen
21 一种高分子抗肿瘤前药及其制备方法 专利 汤朝晖;孙环娇;于海洋;吕世贤;张大为;陈学思
22 Thermosensitive Polypeptide Hydrogels as a Platform for ROS-Triggered Cargo Release with Innate Cytoprotective Ability under Oxidative Stress 期刊论文 Xu Qinghua;He Chaoliang;Ren Kaixuan;Xiao Chunsheng;Chen Xuesi
23 A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics 期刊论文 Song Zhiming;Shi Bo;Ding Jianxun();Zhuang Xiuli;Zhang Xiaonan;Fu Changfeng();Chen Xuesi
24 Synergistic treatment of triple-negative breast cancer by doxorubicin and thioridazine and its nano-formulation 会议论文 Wang Guanyi();Song Wantong;Yang Shengcai;Wen Qingyi;Lv Shixian;Tang Zhaohui;Chen Xuesi()
25 一种生物可降解的医用手术防粘连膜的制备方法 专利 丁建勋;李忠明;张进;庄秀丽;陈学思
26 Polyion complex micelles with gradient pH-sensitivity for adjustable intracellular drug delivery 期刊论文 Jinjin Chen;Jianxun Ding;Ying Zhang;Chunsheng Xiao;Xiuli Zhuang;Xuesi Chen
27 一种超支化聚乙烯亚胺接枝的聚L-甘氨酸共聚物及其制备方法 专利 田华雨;郭兆培;陈学思;陈杰;林琳;孙平杰
28 Highly Bioadhesive Polymer Membrane Continuously Releases Cytostatic and Anti-Inflammatory Drugs for Peritoneal Adhesion Prevention 期刊论文 Li Jiannan;Xu Weiguo;Chen Jinjin;Li Di;Zhang Kai;Liu Tongjun;Ding Jianxun;Chen Xuesi
29 Kartogenin-Incorporated Thermogel Supports Stem Cells for Significant Cartilage Regeneration 期刊论文 Li Xuezhou;Ding Jianxun;Zhang Zhengzheng;Yang Modi;Yu Jiakuo;Wang Jincheng;Chang Fei;Chen Xuesi
30 Synthesis of phenylboronic ester-linked Y-shape polymer via passerini reaction for ROS-responsive drug delivery 会议论文 Zhang Tianhui; Xiao Chunsheng; Zhuang Xiuli; Chen Xuesi
31 Precision-guided long-acting analgesia by Gel-immobilized bupivacaine-loaded microsphere 期刊论文 Zhang Wenjing;Ning Cong;Xu Weiguo;Hu Hanze;Li Mingqiang;Zhao Guoqing;Ding Jianxun;Chen Xuesi
32 Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models 期刊论文 Li Mingqiang;Tang Zhaohui;Zhang Dawei;Sun Hai;Liu Huaiyu;Zhang Ying;Zhang Yuanyuan();Chen Xuesi()
33 一种改性透明质酸遮蔽的金属有机框架、纳米粒子、纳米粒子的制备方法及其应用 专利 田华雨();张滢;徐彩娜;林琳;陈学思
34 Reduction-responsive polypeptide nanogel delivers antitumor drug for improved efficacy and safety 期刊论文 Huang Kexin();Shi Bo;Xu Weiguo;Ding Jianxun();Yang Yu;Liu Haiyan();Zhuang Xiuli;Chen Xuesi
35 Co-delivery of chemotherapeutics and proteins for synergistic therapy 期刊论文 He Chaoliang;Tang Zhaohui;Tian Huayu;Chen Xuesi
36 一种用于负载药物和基因的载体、药物-基因载体系统及其制备方法 专利 田华雨;徐彩娜;陈学思;焦自学;陈杰;林琳;郭兆培
37 Ezrin-targeted calcium (II)-crosslinked nanoparticle intracellularly co-delivers doxorubicin and chlorambucil for synergistic chemotherapy of osteosarcoma 会议论文 Chang Yonghe;Cui Yan;Zhu Jiajun;Ding Jianxun;Zhang Zhiyu;Chen Xuesi
38 Injectable Thermosensitive Polypeptide-Based CDDP-Complexed Hydrogel for Improving Localized Antitumor Efficacy 期刊论文 Yu Shuangjiang; Zhang Dianliang; He Chaoliang; Sun Wujin; Cao Rangjuan; Cui Shusen; Deng Mingxiao; Gu Zhen; Chen Xuesi
39 Injectable glycopolypeptide hydrogels as biomimetic scaffolds for cartilage tissue engineering 期刊论文 Ren Kaixuan;He Chaoliang();Xiao Chunsheng;Li Gao();Chen Xuesi
40 改性聚多糖及其制备方法 专利 汤朝晖;李明强;于海洋;宋万通;陈学思
41 Molecular Strings Significantly Improved the Gene Transfection Efficiency of Polycations 期刊论文 Fang Huapan();Guo Zhaopei;Lin Lin;Chen Jie;Sun Pingjie;Wu Jiayan;Xu Caina;Tian Huayu();Chen Xuesi()
42 一种香菇多糖的提取及分级方法 专利 丁建勋;许维国;庄秀丽;陈学思
43 Synergistic Antitumor Effects of Doxorubicin-Loaded Carboxymethyl Cellulose Nanoparticle in Combination with Endostar for Effective Treatment of Non-Small-Cell Lung Cancer 期刊论文 Li Mingqiang();Tang Zhaohui;Lin Jian;Zhang Yu;Lv Shixian;Song Wantong;Huang Yubin;Chen Xuesi()
44 Injectable Polysaccharide Hydrogels as Biocompatible Platforms for Localized and Sustained Delivery of Antibiotics for Preventing Local Infections 期刊论文 Ziyi Li;Chaoliang He;Baoming Yuan;Xiaoming Dong;Xuesi Chen
45 Mesomeric configuration makes polyleucine micelle an optimal nanocarrier 期刊论文 He Taoyuan;Li Di;Yang Yanan;Ding Jianxun;Jin Feng;Zhuang Xiuli;Chen Xuesi
46 Current Status and Future Prospects of Polymeric Nanocarrier for Tumor Targeting 期刊论文 Yu Haiyang;Tang Zhaohui;Song Wantong;Deng Mingxiao;Chen Xuesi
47 一种氧化响应性PEG化脂质材料、其制备方法及其应用 专利 肖春生;张田慧;庄秀丽;陈学思
48 一种载药聚合物囊泡及其制备方法 专利 丁建勋;张莹;庄秀丽;陈学思
49 Glutathione-degradable drug-loaded nanogel effectively and securely suppresses hepatoma in mouse model 期刊论文 Liu Xingang();Wang Jianmeng();Xu Weiguo;Ding Jianxun();Shi Bo;Huang Kexin;Zhuang Xiuli;Chen Xuesi
50 Efficient recovery of precious metal based on Au-S bond and electrostatic interaction 期刊论文 Li Yuce;Tian Huayu;Xiao Chunsheng;Ding Jianxun;Chen Xuesi
51 一种靶向载药聚合物及其制备方法以及一种聚合物胶束载响应性前药体系及其制备方法 专利 丁建勋;郑盼;陈学思;李杲;姜中雨;王越;陈美杉
52 Positively charged polypeptide nanogel enhances mucoadhesion and penetrability of 10-hydroxycamptothecin in orthotopic bladder carcinoma 期刊论文 Guo Hui();Xu Weiguo;Chen Jinjin;Yan Lesan;Ding Jianxun();Hou Yuchuan();Chen Xuesi()
53 Noncovalent interaction-assisted polymeric micelles for controlled drug delivery 期刊论文 Chunsheng Xiao|Li Chen|Xiuli Zhuang|Xuesi Chen|
54 Tumor microenvironment-responsive hyaluronate-calcium carbonate hybrid nanoparticle enables effective chemotherapy for primary and advanced osteosarcomas 期刊论文 Zhang Yi;Cai Lulu;Li Di;Lao Yeh Hsing;Liu Dingzhuo;Li Mingqiang;Ding Jianxun;Chen Xuesi
55 Preclinical Evaluation of Antitumor Activity of Acid-Sensitive PEGylated Doxorubicin 期刊论文 Diankui Sun;Jianxun Ding;Chunsheng Xiao;Jinjin Chen;Xiuli Zhuang;Xuesi Chen
56 pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent 期刊论文 Sun Diankui;Ding Jianxun;Xiao Chunsheng;Chen Jinjin;Zhuang Xiuli;Chen Xuesi
57 pH- and Amylase-Responsive Carboxymethyl Starch/Poly(2-isobutyl-acrylic acid) Hybrid Microgels as Effective Enteric Carriers for Oral Insulin Delivery 期刊论文 Liu Liang; Zhang Ying; Yu Shuangjiang; Zhang Zhen; He Chaoliang; Chen Xuesi
58 Gold Nanorods-Based Gene Carriers with the Capability of Photoacoustic Imaging and Photothermal Therapy 期刊论文 Chen Jie;Liang Hong;Lin Lin;Guo Zhaopei;Sun Pingjie;Chen Meiwan;Tian Huayu();Deng Mingxiao();Chen Xuesi()
59 糖聚肽高分子的合成、自组装及生物医学应用 期刊论文 肖春生;丁建勋;贺超良;陈学思
60 Polylysine-modified polyethylenimine polymer can generate genetically engineered mesenchymal stem cells for combinational suicidal gene therapy in glioblastoma 期刊论文 Malik Yousra Saeed;Sheikh Muhammad Abid;Xing Zhenkai;Guo Zhaopei;Zhu Xiaojuan;Tian Huayu();Chen Xuesi
61 Guanidinated Thiourea-Decorated Polyethylenimines for Enhanced Membrane Penetration and Efficient siRNA Delivery 期刊论文 Li Yuce;Tian Huayu();Ding Jianxun;Lin Lin;Chen Jie;Gao Shiqian;Chen Xuesi()
62 Systemically administered targeted nanomedicine combined with locally granted nitric oxide suppresses drug-resistance of hepatoma 会议论文 Li Lingyu;Xu Weiguo;Ding Jianxun;Zhuang Xiuli;Chen Xuesi
63 Polymer micro/nanocarrier-assisted synergistic chemohormonal therapy for prostate cancer 期刊论文 He Liang;Xu Weiguo;Wang Xiaoqing;Wang Chunxi;Ding Jianxun;Chen Xuesi
64 Thermo-sensitive polypeptide hydrogel for locally sequential delivery of two-pronged antitumor drugs 期刊论文 Wei Lingyu;Chen Jinjin;Zhao Shuhua;Ding Jianxun;Chen Xuesi
65 Ultrasensitive pH Triggered Charge/Size Dual-Rebound Gene Delivery System 期刊论文 Guan Xiuwen;Guo Zhaopei;Lin Lin;Chen Jie;Tian Huayu();Chen Xuesi()
66 一种吉西他滨衍生物及其制备方法 专利 汤朝晖;杨晨光;于海洋;郭红卫;宋万通;陈学思
67 一种类糖肽及其制备方法、可注射性水凝胶 专利 贺超良;任凯旋;成一龙;肖春生;李杲;陈学思
68 Injectable Polypeptide Hydrogels with Tunable Microenvironment for 3D Spreading and Chondrogenic Differentiation of Bone-Marrow-Derived Mesenchymal Stem Cells 期刊论文 Ren, Kaixuan; Cui, Haitao; Xu, Qinghua; He, Chaoliang; Li, Gao; Chen, Xuesi
69 Synergistic co-delivery of doxorubicin and paclitaxel by porous PLGA microspheres for pulmonary inhalation treatment 期刊论文 Tianshi Feng;Huayu Tian;Caina Xu;Lin Lin;Zhigang Xie;Michael Hon-Wah Lam;Haojun Liang;Xuesi Chen
70 Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography 期刊论文 Song Wantong();Tang Zhaohui();Zhang Dawei;Burton Neal;Driessen Wouter;Chen Xuesi()
71 Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade 期刊论文 Shuangjiang Yu;Wang Chao;Yu Jicheng;Wang Jinqiang;Lu Yue;Zhang Yuqi;Zhang Xudong;Hu Quanyin;Sun Wujin;Chaoliang He;Xuesi Chen;Gu Zhen
72 Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors 期刊论文 Chen Jinjin;Ding Jianxun;Wang Yucai;Cheng Jianjun;Ji Shengxiang;Zhuang Xiuli;Chen Xuesi
73 一种高分子CA4键合药物化合物及其制备方法 专利 汤朝晖; 宋万通; 于海洋; 牛月伟; 马胜; 张瑜; 陈学思
74 Tumor-homotypic reduction-responsive polypeptide nanogels for prostate cancer chemotherapy 会议论文 He Liang;Wang Jixue;Guo Hui;Wang Chunxi;Ding Jianxun;Chen Xuesi
75 Peptide-Based and Polypeptide-Based Gene Delivery Systems 期刊论文 Jie Chen;Xiuwen Guan;Yingying Hu;Huayu Tian;Xuesi Chen()
76 Gold Nanorods Electrostatically Binding Nucleic Acid Probe for In Vivo MicroRNA Amplified Detection and Photoacoustic Imaging-Guided Photothermal Therapy 期刊论文 Yan Nan;Wang Xiaojing;Lin Lin;Song Tingjie;Sun Pingjie;Tian Huayu();Liang Haojun();Chen Xuesi()
77 Polylysine-modified polyethylenimine (PEI-PLL) mediated VEGF gene delivery protects dopaminergic neurons in cell culture and in rat models of Parkinon's Disease (PD) 期刊论文 Sheikh Muhammad Abid;Malik Yousra Saeed;Xing Zhenkai;Guo Zhaopei;Tian Huayu();Zhu Xiaojuan();Chen Xuesi()
78 Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma 期刊论文 Di Li;Weiguo Xu;Pengqiang Li;Jianxun Ding;Zhihang Cheng;Li Chen;Lesan Yan;Xuesi Chen
79 Coadministration of Vascular Disrupting Agents and Nanomedicines to Eradicate Tumors from Peripheral and Central Regions 期刊论文 Song Wantong();Tang Zhaohui();Zhang Dawei;Yu Haiyang;Chen Xuesi()
80 Regular sleep and cytotoxic nanomedicine targeting tumor-associated macrophages for synergistic immunotherapy of breast cancer 会议论文 Xu Weiguo;Ding Jianxun;Zhuang Xiuli;Chen Xuesi
81 Reducing the toxicity of amphotericin B by encapsulation using methoxy poly(ethylene glycol)-b-poly(L-glutamic acid-co-L-phenylalanine) 期刊论文 Chenguang Yang;Baiji Xue;Wantong Song;Bo Kan;Dawei Zhang;Haiyang Yu;Na Shen;Xuefeng Li;Zhaohui Tang;Xuesi Chen
82 Injectable electroactive hydrogels based on Pluronic (R) F127 and tetraaniline copolymer 期刊论文 E. Jin;Zhen Zhang;Hua Lian;Xin Chen;Chunsheng Xiao;Xiuli Zhuang;Xuesi Chen
83 Scavenger Receptor-Mediated Targeted Treatment of Collagen-Induced Arthritis by Dextran Sulfate-Methotrexate Prodrug 期刊论文 Yang Modi;Ding Jianxun;Feng Xiangru;Chang Fei;Wang Yinan;Gao Zhongli;Zhuang Xiuli;Chen Xuesi
84 Dual Stimuli-Responsive Nanoparticle-Incorporated Hydrogels as an Oral Insulin Carrier for Intestine-Targeted Delivery and Enhanced Paracellular Permeation 期刊论文 Liu Liang; Zhang Ying; Yu Shuangjiang; Yang Zhiming; He Chaoliang; Chen Xuesi
85 一种聚氨基酸及其制备方法和载药胶束 专利 丁建勋();何陶媛;庄秀丽;陈学思
86 A pH-sensitive cationic micelle for siRNA delivery 会议论文 Fang Huapan;Tian Huayu();Chen Xuesi
87 Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer 期刊论文 Lv Shixian;Tang Zhaohui;Li Mingqiang;Lin Jian;Song Wantong;Liu Huaiyu;Huang Yubin;Zhang Yuanyuan;Chen Xuesi
88 Receptor and Microenvironment Dual-Recognizable Nanogel for Targeted Chemotherapy of Highly Metastatic Malignancy 期刊论文 Jinjin Chen;Jianxun Ding;Weiguo Xu;Tianmeng Sun;Haihua Xiao;Xiuli Zhuang;Xuesi Chen
89 A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment 期刊论文 Gao Shiqian;Tian Huayu;Xing Zhenkai;Zhang Dawei;Guo Ye;Guo Zhaopei;Zhu Xiaojuan();Chen Xuesi()
90 Charge-conversional zwitterionic copolymer as pH-sensitive shielding system for effective tumor treatment 期刊论文 Jie Chen();Xuan Dong;Tianshi Feng;Lin Lin;Zhaopei Guo;Jialiang Xia;Huayu Tian();Xuesi Chen()
91 一种聚氨基酸嵌段共聚物及其制备方法和应用 专利 丁建勋();陈进进;魏伶羽;庄秀丽;陈学思
92 Composite scaffold with gradient content of simvastatin for enhanced large cranial defect repair 会议论文 Wu Huiyong();Wei Junchao();Wu Huiyong;Zhu Bitao;Ding Jianxun;Chen Xuesi;Zhu Bitao
93 A cooperative polymeric platform for tumor-targeted drug delivery 期刊论文 Song Wantong();Tang Zhaohui();Zhang Dawei;Li Mingqiang;Gu Jingkai;Chen Xuesi()
94 Pharmacokinetics, biodistribution and in vivo efficacy of cisplatin loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) complex nanoparticles for tumor therapy 期刊论文 Yu Haiyang();Tang Zhaohui();Zhang Dawei;Song Wantong;Zhanga Ying;Yang Yan;Ahmad Zaheer;Chen Xuesi
95 A polypeptide based podophyllotoxin conjugate for the treatment of multi drug resistant breast cancer with enhanced efficiency and minimal toxicity 期刊论文 Zhou Huicong;Lv Shixian;Zhang Dawei;Deng Mingxiao;Zhang Xuefei;Tang Zhaohui;Chen Xuesi
96 Dihydroartemisinin increases gemcitabine therapeutic efficacy in ovarian cancer by inducing reactive oxygen species 期刊论文 Yang Shengcai;Zhang Dawei;Shen Na;Wang Guanyi;Tang Zhaohui;Chen Xuesi
97 一种可注射水凝胶及其制备方法 专利 贺超良; 李自伊; 陈学思
98 Ionic-crosslinked polysaccharide/PEI/DNA nanoparticles for stabilized gene delivery 期刊论文 Zhang Ying;Lin Lin;Liu Liang;Liu Feng;Maruyama Atsushi;Tian Huayu();Chen Xuesi
99 In Vitro Studies on Regulation of Osteogenic Activities by Electrical Stimulus on Biodegradable Electroactive Polyelectrolyte Multilayers 期刊论文 Haitao Cui;Yu Wang;Liguo Cui;Peibiao Zhang;Xianhong Wang;Yen Wei;Xuesi Chen
100 一种基于多酚的配位聚合物纳米颗粒及其制备方法 专利 田华雨();徐彩娜;王艳兵;陈杰;林琳;郭兆培;陈学思
101 Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy 期刊论文 Li Di();Han Jiandong;Ding Jianxun();Chen Li();Chen Xuesi
102 Scavenger receptor-targeted dextran sulfate-methotrexate prodrug for treatment of collagen-induced arthritis 会议论文 Yang Modi;Chang Fei;Ding Jianxun;Wang Jincheng;Gao Zhongli;Zhuang Xiuli;Chen Xuesi
103 Surface dual-targeting equipped nanogels intracellularly deliver cytotoxic agent to suppress highly metastatic malignancy 会议论文 Chen Jinjin;Ding Jianxun;Xu Weiguo;Zhuang Xiuli;Chen Xuesi
104 Polymeric Nanocarriers for Drug Delivery in Osteosarcoma Treatment 期刊论文 Gu Xueyuan;Ding Jianxun();Zhang Zhiyu;Li Qin;Zhuang Xiuli;Chen Xuesi
105 氨基酸嵌段共聚物、其制备方法及温度敏感型水凝胶 专利 贺超良;于双江;陈学思
106 Injectable, Biomolecule-Responsive Polypeptide Hydrogels for Cell Encapsulation and Facile Cell Recovery through Triggered Degradation 期刊论文 Qinghua Xu;Chaoliang He;Zhen Zhang;Kaixuan Ren;Xuesi Chen
107 Electroactive polyion complex polypeptide hydrogel locally supplies methylprednisolone and microsphere-entrapped neurotrophin-3 for spinal cord injury repair 会议论文 Zhang Qingzheng;Ning Cong;Fu Changfeng;Ding Jianxun;Zhuang Xiuli;Chen Xuesi
108 Cisplatin Loaded Methoxy Poly (ethylene glycol)-block-Poly (L-glutamic acid-co-L-Phenylalanine) Nanoparticles against Human Breast Cancer Cell 期刊论文 Ahmad Zaheer();Tang Zhaohui();Shah Afzal;Lv Shixian;Zhang Dawei;Zhang Ying;Chen Xuesi
109 pH and redox dual-sensitive polysaccharide nanoparticles for the efficient delivery of doxorubicin 期刊论文 Yang Shengcai;Tang Zhaohui;Zhang Dawei;Deng Mingxiao;Chen Xuesi
110 Injectable hydrogel-microsphere construct with sequential degradation for locally synergistic chemotherapy 期刊论文 Zheng Yuhao;Cheng Yilong;Chen Jinjin;Ding Jianxun;Li Mingqiang;Li Chen;Wang Jin-Cheng;Chen Xuesi
111 一种高分子CA4键合药及其制备方法 专利 汤朝晖();宋万通;于海洋;牛月伟;张大为;马胜;张瑜;陈学思
112 Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase 期刊论文 Guan Xiuwen;Chen Jie;Hu Yingying;Lin Lin;Sun Pingjie;Tian Huayu();Chen Xuesi
113 一种具有电荷可翻转的聚离子型胶束遮蔽体系及其制备方法 专利 丁建勋;姜中雨;庄秀丽;陈学思
114 一种铁配位聚合物纳米颗粒的解离方法及其应用 专利 田华雨();王艳兵;徐彩娜;陈学思
115 一种聚阳离子基因载体、其制备方法及其应用 专利 田华雨;方华攀;林琳;陈杰;郭兆培;陈学思
116 Methoxy poly (ethylene glycol)-block-poly (glutamic acid)-graft-6-(2-nitroimidazole) hexyl amine nanoparticles for potential hypoxia-responsive delivery of doxorubicin 期刊论文 Ahmad Zaheer();Lv Shixian;Tang Zhaohui();Shah Afzal;Chen Xuesi
117 The suppression of metastatic lung cancer by pulmonary administration of polymer nanoparticles for co-delivery of doxorubicin and Survivin siRNA 期刊论文 Xu Caina;Tian Huayu;Wang Ping;Wang Yanbing;Chen Xuesi
118 Evaluation of absorbable composite polylactide–hydroxyapatite bone fixation devices: a cohort study 期刊论文 Ding Jianxun()();Zhuang Xiuli;Chen Xuesi
119 Injectable polysaccharide hybrid hydrogels as scaffolds for burn wound healing 期刊论文 Li Ziyi;Yuan Baoming;Dong Xiaoming;Duan Lijie;Tian Huayu;He Chaoliang;Chen Xuesi
120 多羟基聚酯及其制备方法 专利 肖春生;邓鸣;丁建勋;庄秀丽;陈学思
121 Solid Tumor Therapy Using a Cannon and Pawn Combination Strategy 期刊论文 Song Wantong();Tang Zhaohui;Zhang Dawei;Lv Shixian;Liu Zhilin;Chen Xuesi;Wen Xue;Deng Mingxiao;Lv Shixian;Liu Zhilin;Tang ZH();Chen XS()
122 一种基因传递系统及其制备方法 专利 田华雨();关秀文;陈学思;郭兆培;林琳;陈杰;徐彩娜
123 Synergistic therapeutic effects of Schiffs base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model 期刊论文 Wu;X. L.;He;C. L.;Wu;Y. D.;Chen;X. S.
124 一种氧化葡聚糖-硼替佐米-阿霉素-RGD肽键合药及其制备方法 专利 丁建勋();许维国;庄秀丽;陈学思
125 Cisplatin Loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Complex Nanoparticles for Potential Cancer Therapy: Preparation, In Vitro and In Vivo Evaluation 期刊论文 Yu Haiyang();Tang Zhaohui();Li Mingqiang;Song Wantong;Zhang Dawei;Zhang Ying;Yang Yan;Sun Hai;Deng Mingxiao;Chen Xuesi
126 A charge-conversional intracellular-activated polymeric prodrug for tumor therapy 期刊论文 Wang Yue;Lv Shixian;Deng Mingxiao();Tang Zhaohui();Chen Xuesi
127 一种聚酯型聚氨酯形状记忆材料及其制备方法 专利 贺超良;刘梁;于双江;庄秀丽;陈学思
128 A poly(L-glutamic acid)-combretastatin A4 conjugate for solid tumor therapy: Markedly improved therapeutic efficiency through its low tissue penetration in solid tumor 期刊论文 Liu Tianzhou();Zhang Dawei;Song Wantong;Tang Zhaohui();Zhu Jiaming;Ma Zhiming;Wang Xudong;Chen Xuesi;Tong Ti()
129 Poly(ethylene glycol)-poly-l-glutamate complexed with polyethyleneimine-polyglycine for highly efficient gene delivery in vitro and in vivo 期刊论文 Guo Zhaopei;Lin Lin;Chen Jie;Zhou Xingzhi;Chan Hon Fai;Chen Xuesi;Tian Huayu();Chen Meiwan()
130 Targeted hydroxyethyl starch prodrug for inhibiting the growth and metastasis of prostate cancer 期刊论文 Zhao Kaidong();Li Di;Xu Weiguo;Ding Jianxun();Jiang Weiqian;Li Mingqiang();Wang Chunxi();Chen Xuesi
131 Codelivery of Antitumor Drug and Gene by a pH-Sensitive Charge-Conversion System 期刊论文 Guan Xiuwen;Li Yanhui();Jiao Zixue;Lin Lin;Chen Jie;Guo Zhaopei;Tian Huayu();Chen Xuesi
132 一种用于光学成像的化合物、制备方法及其键合物 专利 汤朝晖();牛月伟;宋万通;陈学思
133 Injectable Polypeptide Hydrogel as Biomimetic Scaffolds with Tunable Bioactivity and Controllable Cell Adhesion 期刊论文 Qinghua Xu;Zhen Zhang;Chunsheng Xiao;Chaoliang He;Xuesi Chen
134 miRNA oligonucleotide and sponge for miRNA-21 inhibition mediated by PEI-PLL in breast cancer therapy 期刊论文 Gao Shiqian; Tian Huayu; Guo Ye; Li Yuce; Guo Zhaopei; Zhu Xiaojuan; Chen Xuesi
135 Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers 期刊论文 Chen Jinjin;Ding Jianxun();Xiao Chunsheng;Zhuang Xiuli;Chen Xuesi()
136 Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment 期刊论文 Guanyi Wang();Wantong Song;Na Shen;Haiyang Yu;Mingxiao Deng;Zhaohui Tang();Xueqi Fu();Xuesi Chen
137 5-Fluorouracil loaded thermosensitive PLGA-PEG-PLGA hydrogels for the prevention of postoperative tendon adhesion 期刊论文 Yuan Baoming;He Chaoliang;Dong Xiaoming;Wang Jincheng;Gao Zhongli;Wang Qian;Tian Huayu;Chen Xuesi
138 一种高转染效率低细胞毒性的阳离子基因载体及其制备方法 专利 田华雨;方华攀;林琳;郭兆培;陈杰;孙平杰;陈学思
139 Cisplatin complex and preparation method thereof 专利 Zhaohui Tang; Haiyang Yu; Wantong Song; Mingqiang Li; Xiuli Zhuang; Xuesi Chen
140 Exploring the in vivo fates of RGD and PEG modified PEI/DNA nanoparticles by optical imaging and optoacoustic imaging 期刊论文 Lin Lin;Chen Jie;Guo Zhaopei;Song Wantong;Zhang Dawei;Tian Huayu();Chen Xuesi
141 Nanotherapeutics relieve rheumatoid arthritis 期刊论文 Yang Modi;Feng Xiangru;Ding Jianxun;Chang Fei;Chen Xuesi
142 一种聚苯胺纳米粒子的制备方法及其应用 专利 汤朝晖;李明强;高中辉;于海洋;陈学思
143 Poly (L-glutamic acid)-g-methoxy poly (ethylene glycol)-gemcitabine conjugate improves the anticancer efficacy of gemcitabine 期刊论文 Yang Chenguang;Song Wantong;Zhang Dawei;Yu Haiyang;Yin Lei;Shen Na;Deng Mingxiao;Tang Zhaohui;Gu Jingkai;Chen Xuesi
144 聚酯类材料担载双硫仑的纳米粒及其应用、药物制剂及其应用 专利 汤朝晖();宋万通;于海洋;张瑜;陈学思
145 Chirality-mediated polypeptide micelles for regulated drug delivery 期刊论文 Jianxun Ding;Chen Li;Ying Zhang;Weiguo Xu;Jincheng Wang;Xuesi Chen
146 Micellization of Antineoplastic Agent to Significantly Upregulate Efficacy and Security 期刊论文 Li Chen();Xu Weiguo;Ding Jianxun();Zhang Ying;Wang Jincheng();Zhuang Xiuli;Chen Xuesi
147 Cholesterol-Enhanced Polylactide-Based Stereocomplex Micelle for Effective Delivery of Doxorubicin 期刊论文 Wang Jixue;Xu Weiguo;Ding Jianxun();Lu Shengfan;Wang Xiaoqing();Wang Chunxi;Chen Xuesi
148 Reduction-Responsive Polypeptide Micelles for Intracellular Delivery of Antineoplastic Agent 期刊论文 Xu Weiguo();Ding Jianxun();Chen Xuesi
149 PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatment 期刊论文 Hecheng Ma;Chaoliang He;Yilong Cheng;Dongsong Li;Yubao Gong;Jianguo Liu;Huayu Tian;Xuesi Chen
150 Multifunctional Theranostic Nanoparticles Derived from Fruit-Extracted Anthocyanins with Dynamic Disassembly and Elimination Abilities 期刊论文 Xu Caina();Wang Yanbing();Yu Haiyang;Tian Huayu();Chen Xuesi()
151 Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel 期刊论文 Lv Shixian();Tang Zhaohui;Zhang Dawei;Song Wantong;Li Mingqiang;Lin Jian;Liu Huaiyu;Chen Xuesi()
152 Reactive Oxygen Species (ROS) Responsive Polymers for Biomedical Applications 期刊论文 Xu Qinghua;He Chaoliang;Xiao Chunsheng;Chen Xuesi
153 Poly(ornithine-co-arginine-co-glycine-co-aspartic Acid): Preparation via NCA Polymerization and its Potential as a Polymeric Tumor-Penetrating Agent 期刊论文 Yu Haiyang();Tang Zhaohui();Zhang Dawei;Song Wantong;Duan Taicheng;Gu Jingkai;Chen Xuesi
154 A reduction-sensitive thermo-responsive polymer: Synthesis, characterization, and application in controlled drug release 期刊论文 Li Song;Bao Zhang;E Jina;Chunsheng Xiao;Gao Li;Xuesi Chen
155 改性聚乙烯亚胺及其制备方法、药物-基因载体系统及其制备方法 专利 田华雨;徐彩娜;陈学思;焦自学;郭兆培;林琳;陈杰
156 Nanogel-Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo-Protein Combination Therapy 期刊论文 Wu Xilong;He Chaoliang;Wu Yundi;Chen Xuesi();Cheng Jianjun()
157 高分子阿霉素键合药及其制备方法 专利 庄秀丽; 丁建勋; 张建成; 陈学思
158 Stereocomplex micelle from nonlinear enantiomeric copolymers efficiently transports antineoplastic drug 期刊论文 Wang Jixue;Shen Kexin;Xu Weiguo;Ding Jianxun;Wang Xiaoqing;Liu Tongjun();Wang Chunxi();Chen Xuesi
159 Polymeric nanostructured materials for biomedical applications 期刊论文 Tang Zhaohui();He Chaoliang;Tian Huayu;Ding Jianxun;Hsiao Benjamin S.();Chu Benjamin;Chen Xuesi()
160 One-Step Click Chemistry-Synthesized Cross-Linked Prodrug Nanogel for Highly Selective Intracellular Drug Delivery and Upregulated Antitumor Efficacy 期刊论文 Zhang Yu();Ding Jianxun;Li Mingqiang;Chen Xin;Xiao Chunsheng();Zhuang Xiuli;Huang Yubin;Chen Xuesi()
161 Self-Stabilized Hyaluronate Nanogel for Intracellular Codelivery of Doxorubicin and Cisplatin to Osteosarcoma 期刊论文 Zhang Yi;Wang Feng;Li Mingqiang;Yu Zhiqiang;Qi Ruogu;Ding Jianxun;Zhang Zhiyu;Chen Xuesi
162 Oxidized hyaluronic acid modified by l-Argine for siRNA delivery 会议论文 Zhang Ying; Liu Liang; Tian Huayu; Chen Xuesi
163 Targeted co-delivery of dual-pronged cytotoxic agents with pH-responsive nanoparticle for synergistic chemotherapy 会议论文 Di Li;Li Chen;Xiuli Zhuang;Xuesi Chen
164 Characterization of nanostructured ureteral stent with gradient degradation in a porcine model 期刊论文 Wang Xiaoqing;Shan Hongli;Wang Jixue;Hou Yuchuan;Ding Jianxun();Chen Qihui;Guan Jingjing;Wang Chunxi();Chen Xuesi
165 生物医用高分子材料 专著 赵长生;孙树东
166 Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic 期刊论文 Xu Weiguo();Ding Jianxun();Xiao Chunsheng;Li Lingyu;Zhuang Xiuli;Chen Xuesi()
167 One-pot synthesis of pH and ROS dual responsive nanogels for anti-cancer drug delivery 会议论文 Xin Chen;Chunsheng Xiao;Xiuli Zhuang;Xuesi Chen
168 pH and reduction dual responsive cross-linked polyurethane micelles as an intracellular drug delivery system 期刊论文 Yu Shuangjiang;He Chaoliang();Lv Qiang;Sun Hai;Chen Xuesi
169 Cisplatin-loaded polymeric nanoparticles: Characterization and potential exploitation for the treatment of non-small cell lung carcinoma 期刊论文 Shi Chunshan;Yu Haiyang;Sun Dejun();Ma Lili;Tang Zhaohui();Xiao Qiusheng;Chen Xuesi
170 一种可释放SO2的聚合物、其制备方法及其应用和纳米胶束 专利 肖春生;沈伟;陈学思
171 In situ dual-crosslinked nanoparticles for tumor targeting gene delivery 期刊论文 Zhang Ying;Liu Liang;Lin Lin;Chen Jie;Tian Huayu();Chen Xuesi();Maruyama Atsushi
172 一种水溶性的氨基酸嵌段共聚物及其制备方法和应用 专利 汤朝晖;吕世贤;于海洋;马胜;周卉聪;陈学思
173 Activated macrophage-targeted dextran-methotrexate/folate conjugate prevents deterioration of collagen-induced arthritis in mice 期刊论文 Yang Modi();Ding Jianxun();Zhang Ying;Chang Fei();Wang Jincheng;Gao Zhongli();Zhuang Xiuli;Chen Xuesi
174 Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis 期刊论文 Li Mingqiang();Tang Zhaohui;Zhang Yu;Lv Shixian;Li Quanshun;Chen Xuesi()
175 一种高分子前药及其制备方法 专利 肖春生;陈新;张羽;丁建勋;庄秀丽;陈学思
176 A pH-Responsive Detachable PEG Shielding Strategy for Gene Delivery System in Cancer Therapy 期刊论文 Guan Xiuwen();Guo Zhaopei;Wang Tinghong;Lin Lin;Chen Jie;Tian Huayu();Chen Xuesi()
177 LHRH-peptide conjugated dextran nanoparticles for targeted delivery of cisplatin to breast cancer 期刊论文 Li Mingqiang();Tang Zhaohui;Zhang Yu;Lv Shixian;Yu Haiyang;Zhang Dawei;Hong Hua;Chen Xuesi()
178 A glutathione-responsive sulfur dioxide polymer prodrug as a nanocarrier for combating drug-resistance in cancer chemotherapy 期刊论文 Shen Wei;Liu Wanguo;Yang Huailin;Zhang Peng;Xiao Chunsheng;Chen Xuesi
179 Recent progress in cationic polymeric gene carriers for cancer therapy 期刊论文 Xu Caina();Tian Huayu();Chen Xuesi()
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