【21274117】聚合物纤维制控释载药胶束及靶向作用机制国家自然基金项目

聚合物纤维制控释载药胶束及靶向作用机制

项目批准号： 21274117

批准年份： 2012

学科分类： B0507.医用材料化学

项目负责人：李孝红

资助类别：面上项目

负责人职称：教授

依托单位：西南交通大学

资助金额： 85万元

关键词：靶向作用;聚合物纤维;肿瘤环境敏感;载药胶束;控释机制

起止时间： 2013-01-01到2016-12-31

中英文摘要
结题摘要
结题报告
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序号	标题	类型	作者
1	Micropatterned coculture of vascular endothelial and smooth muscle cells on layered electrospun fibrous mats toward blood vessel engineering	期刊论文	Liu, Yaowen\|Lu, Jinfu\|Wei, Jiaojun\|Li, Xiaohong\|
2	Pharmacokinetics and antitumor efficacy of micelles assembled from multiarmed amphiphilic copolymers with drug conjugates in comparison with drug-encapsulated micelles	期刊论文	Chen, Maohua\|Zhang, Yun\|Chen, Zhoujiang\|Li, Xiaohong\|
3	Hepatocyte spheroid culture on fibrous scaffolds with grafted functional ligands as an in vitro model for predicting drug metabolism and hepatotoxicity	期刊论文	Yaowen Liu\|Hong Zhang\|Jianmei Chen\|Xiaohong Li\|
4	Spatial distribution and antitumor activities after intratumoral injection of fragmented fibers with loaded hydroxycamptothecin	期刊论文	Xiaoming Luo\|Maohua Chen\|Jinfu Lu\|Xiaohong Li\|
5	Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism	期刊论文	Lu, Jinfu\|Lei, Dongmei\|Yan, Shili\|Li, Xiaohong\|
6	Tunable release of chemotherapeutic and vascular disrupting agents from injectable fiber fragments potentiates combination chemotherapy	期刊论文	Wei, Jiaojun\|Chen, Maohua\|Zhang, Hong\|Li, Xiaohong\|
7	Genetically engineering of Escherichia coli and immobilization on electrospun fibers for drug delivery purposes	期刊论文	Song, Haixing\|Luo, Xiaoming\|Zhang, Hong\|Li, Xiaohong\|
8	Engineering blood vessels through micropatterned co-culture of vascular endothelial and smooth muscle cells on bilayered electrospun fibrous mats with pDNA inoculation	期刊论文	Jinfu Lu\|Huinan Li\|Jiaojun Wei\|Xiaohong Li\|
9	Folate-Decorated and Reduction-Sensitive Micelles Assembled from Amphiphilic Polymer-Camptothecin Conjugates for Intracellular Drug Delivery	期刊论文	Chen, Maohua\|Chen, Zhoujiang\|Zhao, Yuancong\|Li, Xiaohong\|
10	Tunable conjugation densities of camptothecin on hyaluronic acid for tumor targeting and reduction-triggered release	期刊论文	He, Nan\|Chen, Maohua\|Zhao, Long\|Li, Xiaohong\|
11	Shape effects of electrospun fiber rods on the tissue distribution and antitumor efficacy	期刊论文	Liu, Yuan\|Chen, Maohua\|Luo, Xiaoming\|Li, Xiaohong\|
12	Tuning the conductivity and inner structure of electrospun fibers to promote cardiomyocyte elongation and synchronous beating	期刊论文	Xu, Guisen\|Wei, Jiaojun\|Zhang, Zhibin\|Li, Xiaohong\|
13	Promoted antitumor activities of acid-labile electrospun fibers loaded with hydroxycamptothecin via intratumoral implantation	期刊论文	Yang, Shuxia\|Yan, Shili\|Jia, Guoqing\|Li, Xiaohong\|
14	Promoted regeneration of mature blood vessels by electrospun fibers with loaded multiple pDNA-calcium phosphate nanoparticles	期刊论文	Guo, Xueqin\|Wang, Huan\|Liu, Yaowen\|Li, Xiaohong\|
15	Electrospun Fibrous Mats on Lithographically Micropatterned Collectors to Control Cellular Behaviors	期刊论文	Yan, Shili\|Yu, Junsheng\|Weng, Jie\|Li, Xiaohong\|
16	Ratiometric fluorescent response of electrospun fibrous strips for real-time sensing of alkaline phosphatase in serum	期刊论文	Song Xiaojie\|Wei Jiaojun\|Zhang Zhao\|Li Xiaohong\|
17	Electrosprayed Microparticles with Loaded pDNA-Calcium Phosphate Nanoparticles to Promote the Regeneration of Mature Blood Vessels	期刊论文	Chen, Fang\|Cheng, Rong\|Luo, Xiaoming\|Li, Xiaohong\|
18	Tuning multiple arms for camptothecin and folate conjugations on star-shaped copolymers to enhance glutathione-mediated intracellular drug delivery	期刊论文	Zhang, Hong\|Liu, Chaoyu\|Li, Huiyan\|Li, Xiaohong\|
19	Therapeutic angiogenesis in ischemic muscles after local injection of fragmented fibers with loaded traditional Chinese medicine	期刊论文	Chen, Maohua\|Zhang, Yun\|Luo, Xiaoming\|Li, Xiaohong\|
20	静电纺聚合物纤维的生物医用功能研究	奖励	李孝红\|翁杰\|崔文国\|杨晔\|
21	Multimeric immobilization of alcohol oxidase on electrospun fibers for valid tests of alcoholic saliva	期刊论文	Yan, Shili\|Chen, Zhoujiang\|Chen, Jianmei\|Li, Xiaohong\|
22	Electrospun Gelatin Fibers with a Multiple Release of Antibiotics Accelerate Dermal Regeneration in Infected Deep Burns	期刊论文	Liu, Zongguang\|Chen, Maohua\|Zhang, Hong\|Li, Xiaohong\|
23	Electrospun Fibrous Mats with Conjugated Tetraphenylethylene and Mannose for Sensitive Turn-On Fluorescent Sensing of Escherichia coli	期刊论文	Yuan, Jiang\|Chen, Maohua\|Zhang, Hong\|Li, Xiaohong\|
24	Antimetastasis and antitumor efficacy promoted by sequential release of vascular disrupting and chemotherapeutic agents from electrospun fibers	期刊论文	Chen, Maohua\|Wei, Jiaojun\|Zhang, Yun\|Li, Xiaohong\|
25	Promoting hepatocyte spheroid formation and functions by coculture with fibroblasts on micropatterned electrospun fibrous scaffolds	期刊论文	Wei, Jiaojun\|Yan, Shili\|Yu, Junsheng\|Li, Xiaohong\|
26	Hepatocyte Cocultures with Endothelial Cells and Fibroblasts on Micropatterned Fibrous Mats to Promote Liver-Specific Functions and Capillary Formation Capabilities	期刊论文	Li, Huinan\|Yan, Shili\|Wei, Jiaojun\|Li, Xiaohong\|
27	Promoting Antitumor Activities of Hydroxycamptothecin by Encapsulation into Acid-Labile Nanoparticles Using Electrospraying	期刊论文	Song, Haixing\|Liu, Chaoyu\|Wu, Guannan\|Li, Xiaohong\|
28	Synergistic Promotion of Blood Vessel Regeneration by Astragaloside IV and Ferulic Acid from Electrospun Fibrous Mats	期刊论文	Wei, Wei\|Chen, Fang\|Guo, Xueqin\|Li, Xiaohong\|
29	Spheroid culture of primary hepatocytes with short fibers as a predictable in vitro model for drug screening	期刊论文	Lu, Jinfu\|Liu, Yaowen\|Yan, Shili\|Li, Xiaohong\|
30	Synergistic antitumor efficacy of redox and pH dually responsive micelleplexes for co-delivery of camptothecin and genes	期刊论文	Chen Zhoujiang\|Xie Songzhi\|Luo Xiaoming\|Li Xiaohong\|

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