单分子仿生界面的构建及其在成像分析中的应用研究

21535002
2015
B0404.化学与生物传感
张书圣
重点项目
教授
临沂大学
300万元
纳米通道;微纳加工;光镊;单分子检测;表面增强拉曼
2016-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Enhanced Peroxidase-like Properties of Graphene-hemin Composite Decorated Au Nanoflower and Application of Electrochemical Aptamer Biosensor for Detection of K562 Cells 期刊论文 Liu Jing;Cui Meirong;Niu Li;Zhou Hong;Zhang Shusheng
2 Chemiluminescence and Bioluminescence Imaging for Biosensing and Therapy: In Vitro and In Vivo Perspectives 期刊论文 Yan Yongcun;Shi Pengfei;Song Weiling;Bi Sai
3 Multicolor Upconversion Nanoprobes Based on a Dual Luminescence Resonance Energy Transfer Assay for Simultaneous Detection and Bioimaging of [Ca2+]i and pHi in Living Cells 期刊论文 Xinyue Song;Zihong Yue;Jiayu Zhang;Yanxialei Jiang;Zonghua Wang;Shusheng Zhang
4 Novel graphene/Au-CdS:Eu composite-based electrochemiluminescence immunosensor for cancer biomarker detection by coupling resonance energy transfer and enzyme catalytic reaction 期刊论文 Meirong Cui;Ruizhen Yu;Xiaomeng Wang;Hong Zhou;Jing Liu;Shusheng Zhang
5 Unambiguous Discrimination of Multiple Protein Biomarkers by Nanopore Sensing with Double-Stranded DNA-Based Probes 期刊论文 Zhen Fang;Liping Liu;Ying Wang;Dongmei Xi;Shusheng Zhang
6 Nucleic Acid Amplification Strategies for Biosensing, Bioimaging and Biomedicine 专著 shusheng zhang
7 Nanopore-Based Selective Discrimination of MicroRNAs with Single-Nucleotide Difference Using Locked Nucleic Acid-Modified Probes 期刊论文 Xi Dongmei;Shang Jizhen;Fan Enguo;You Jinmao;Zhang Shusheng;Wang Hua
8 Cross-catalytic hairpin assembly-based exponential signal amplification for CRET assay with low background noise 期刊论文 Shuzhen Yue;Tingting Zhao;Hongjie Qi;Yongcun Yan;Sai Bi
9 Nuclear-dhell biopolymers initiated by telomere elongation for individual cancer cell imaging and drug delivery 期刊论文 Zhang Zhen;Jiao Yuting;Zhu Mengting;Zhang Shusheng
10 一种高灵敏度荧光定量检测血清肿瘤标志物的纳米复合探针、组合物及荧光定量试剂盒 专利 周宏;刘静;张宁波;张书圣
11 Visual Detection of Single-Nucleotide Polymorphisms and DNA Methyltransferase Based on cation-exchange of CuS nanoparticles and Click Chemistry of Functionalized Gold Nanoparticles 期刊论文 Xiaoru Zhang;Yuan Zhang;Fengting Chen;Ying Li;Shusheng Zhang
12 Optical Nano-Biosensing Interface via Nucleic Acid Amplification Strategy: Construction and Application 期刊论文 Hong Zhou;Jing Liu;Jing-Juan Xu;Shusheng Zhang;Hong-Yuan Chen
13 基于石英晶体微天平的信号放大技术在肿瘤 标志物检测中的应用 期刊论文 刘丽赏;姜耀;李雪梅;张书圣
14 Target-triggered cascade recycling amplification forlabel-free detection of microRNA and molecular logic operations 期刊论文 Sai Bi;Jiayan Ye;Ying Dong;Haoting Li;Wei Cao
15 Ultrasensitive Detection of DNA and Ramos Cell Using In Situ Selective Crystallization Based Quartz Crystal Microbalance 期刊论文 Liu Li-shang;Wu Congcong;Zhang Shusheng
16 Label-free detection of microRNA based on coupling multiple isothermal amplification techniques 期刊论文 Xiangjiang Zheng;Li Niu;Di Wei;Xuemei Li;Shusheng Zhang
17 Quantitative control of CaCO3 growth on quartz crystal microbalance sensors as a signal amplification method 期刊论文 Wu Congcong;Sun Zhaomei;Liu Li-Shang
18 Proximity ligation detection of lectin Concanavalin A and fluorescence imaging cancer cells using carbohydrate functionalized DNA-silver nanocluster probes 期刊论文 Xiaoru Zhang;Fengting Chen;Xiaojie Song;Peng He;ShushengZhang
19 生物纳米孔分析技术研究进展 期刊论文 尚积祯;李志;郗冬梅;张书圣
20 Manipulating the hydrophobicity of DNA as a universal strategy for visual biosensing 期刊论文 Zhong Feng Gao;Rui Liu;Jinhua Wang;Jun Dai;Wei-Hua Huang;Mingjie Liu;Shutao Wang;Fan Xia;Shusheng Zhang;Lei Jiang
21 Coaxial sensing bio-amplifier for ultrasensitive detections of circulating tumor DNAs 期刊论文 Zhen Zhang;Mengting Zhu;Zichao Chen;Xiaomeng Wang;Guang Chen;Shusheng Zhang
22 A versatile homogeneous chemiluminescence biosensing platform based on exonuclease-assisted hybridization chain reaction 期刊论文 Hongjie Qi;Shuzhen Yue;Sai Bi;Caifeng Ding;Weiling Song
23 一种检测癌症标志物微小核糖核酸的试剂盒 专利 张振;王晓蒙;张书圣
24 一种基于QCM的细胞检测方法 专利 刘丽赏;吴从从;陈晋荣;程奕涵;朱家政;张书圣
25 Ultrasensitive Detection of Cancer Cells Combining Enzymatic Signal Amplification with an Aerolysin Nanopore 期刊论文 Dongmei Xi;Zhi Li;Liping Liu;Shiyun Ai;Shusheng Zhang
26 A target-initiated DNA network caged on magnetic particles for amplified chemiluminescence resonance energy transfer imaging of microRNA and targeted drug delivery 期刊论文 Sai Bi;Shuzhen Yue;Weiling Song;Shusheng Zhang
27 Triggered and catalytic self-assembly of hyperbranched DNA structures for logic operations and homogeneous CRET biosensing of microRNA 期刊论文 Sai Bi;Shuzhen Yue;Qiang Wu;Jiayan Ye
28 Inkjet-Printing Patterned Chip on Sticky Superhydrophobic Surface for High-Efficiency Single-Cell Array Trapping and Real-Time Observation of Cellular Apoptosis 期刊论文 Yingnan Sun;Wenhua Song;Xiaohan Sun;Shusheng Zhang
29 Initiator-catalyzed self-assembly of duplex-looped DNA hairpin motif based on strand displacement reaction for logic operations and amplified biosensing 期刊论文 Sai Bi;Shuzhen Yue;Qiang Wu;Jiayan Ye
30 Electrochemiluminescence-Microscopy for microRNA Imaging in Single Cancer Cell Combined with Chemotherapy-Photothermal Therapy 期刊论文 Zhang Huairong;Gao Wanxia;Liu Yong;Sun Yingnan;Jiang Yanxialei;Zhang Shusheng
31 基于纳米多孔金片电极的电化学免疫传感器对巯基乙酸的检测 专利 丁彩凤;张伟;宋维岭;张书圣
32 肿瘤早期高通量电化学发光检测方法的构建 专利 周 宏;刘静;张宁波;张书圣
33 一种前列腺特异性抗原检测试剂与试剂盒 专利 周宏;刘静;张宁波;张书圣
34 Self-assembly of nucleic acid molecular aggregates catalyzed by a triple-helix probe for miRNA detection and single cell imaging 期刊论文 Zhang Zhen;Wang Yuanyuan;Zhang Ningbo;Zhang Shusheng
35 Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring 期刊论文 Zhang Zhen;Jiao Yuting;Wang Yuanyuan;Zhang Shusheng
36 DNA-spheres Decorated Magnetic Nanocomposite Based on Terminal Transfer Reaction for Versatile Target Detection and Cellular Targeted Drug Delivery 期刊论文 Guo Yingshu;Wang Yujie;Li Shuang;Niu Li;Wei Di;Zhang Shusheng
37 Ultrasensitive SERS detection of highly homologous miRNAs by generating 3D organic-nanoclusters and a functionalized chip with locked nucleic acid probes 期刊论文 Mengting Zhu;Zhaomei Sun;Zhen Zhang;Shusheng Zhang
38 Self‐Assembly of Bidirectional‐Signal Nanoclusters for Two miRNAs Simultaneously Monitoring in Single Cancer Cells 期刊论文 Yuting Jiao;Mengting Zhu;Xiaomeng Wang;Zhen Zhang;Shusheng Zhang
39 Integration of intracellular telomerase monitoring by electrochemiluminescence technology and targeted cancer therapy by reactive oxygen species 期刊论文 Zhang Huairong;Li Binxiao;Sun Zhaomei;Zhou Hong;Zhang Shusheng
40 Label-free Electrochemical Detection of ATP Based on Amino-functionalized Metal-organic Framework 期刊论文 Shi Pengfei;Zhang Yuanchao;Yu Zhaopeng;Zhang Shusheng
41 Hybridization chain reaction: a versatile molecular tool for biosensing, bioimaging, and biomedicine 期刊论文 Bi Sai;Yue Shuzhen;Zhang Shusheng
42 Sandwich-Structured Upconversion Nanoprobes Coated with a Thin Silica Layer for Mitochondria-Targeted Cooperative Photodynamic Therapy for Solid Malignant Tumors 期刊论文 Song Xinyue;Yue Zihong;Hong Tongtong;Wang Zonghua;Zhang Shusheng
43 Preparation of a Novel Raman Probe and Its Application in the Detection of Circulating Tumor Cells and Exosomes 期刊论文 Zhang Xiaoru;Liu Chao;Pei Yujiao;Song Weiling;Zhang Shusheng
44 Programmable strand displacement-based magnetic separation for simultaneous amplified detection of multiplex microRNAs by chemiluminescence imaging array 期刊论文 Shuzhen Yue;Tingting Zhao;Sai Bi;Zhipeng Zhang
45 Dual-activator codoped upconversion nanoprobe with core-multishell structure for in vitro and in vivo detection of hydroxyl radical 期刊论文 Song Xinyue;Zhang Jiayu;Yue Zihong;Wang Zonghua;Liu Zhihong;Zhang Shusheng
46 一种适体和鲁米诺-金纳米粒子功能化的RNA膜及其制备方法和应用 专利 郭英姝;尚鑫鑫;刘斐;张书圣
47 一种新型人工模拟酶的合成及对糖基检测方法的构建 专利 刘静;周宏;张书圣
48 Target-triggered dynamic hairpin assembly for signal amplification of microRNA and oncogenes and its application in live-cell imaging 期刊论文 Li Yuanfang;Yue Shuzhen;Qi Hongjie;Ding Caifeng;Song Weiling;Bi Sai
49 Target-Catalyzed DNA Four-WayJunctions for CRET Imaging of MicroRNA, Concatenated Logic Operations, andSelf-Assembly of DNA Nanohydrogels for Targeted Drug Delivery 期刊论文 Sai Bi;Bao Xiu;Jiayan Ye;Ying Dong
50 Applying DNA rolling circle amplification in fluorescence imaging of cell surface glycans labeled by a metabolic method 期刊论文 Xiaoru Zhang;Ruijuan Li;Yuanyuan Chen;Shusheng Zhang;Wenshuang Wang;Fuchuan Li
51 Interface engineering of the Ni(OH)2–Ni3N nanoarray heterostructure for the alkaline hydrogen evolution reaction 期刊论文 Min Gao;Lanlan Chen;Zhenhua Zhang;Xuping Sun;Shusheng Zhang
52 Diagnosis–Therapy Integrative Systems based on Magnetic RNA Nanoflowers for Co-drug Delivery and Targeted Therapy 期刊论文 Guo Yingshu;Li Shuang;Wang Yujie;Zhang Shusheng
53 Efficient double-quenching of electrochemiluminescence from CdS:Eu QDs by hemin-graphene-Au nanorods ternary composite for ultrasensitive immunoassay 期刊论文 Liu Jing;Cui Meirong;Zhou Hong;Zhang Shusheng
54 Efficient Enhancement of Electrochemiluminescence from Cadmium Sulfide Quantum Dots by Glucose Oxidase Mimicking Gold Nanoparticles for Highly Sensitive Assay of Methyltransferase Activity 期刊论文 Zhou Hong;Han Tongqian;Wei Qin;Zhang Shusheng
55 Nanogold Flower-Inspired Nanoarchitectonics Enables Enhanced Light-to-Heat Conversion Ability for Rapid and Targeted Chemo-Photothermal Therapy of a Tumor 期刊论文 Liu Jing;Zhai Fenfen;Zhou Hong;Yang Wenrong;Zhang Shusheng
56 一种基于QCM的核酸序列检测方法 专利 刘丽赏;吴从从;陈晋荣;张振麟;张书圣
57 一种基于晶体生长的QCM信号放大方法 专利 刘丽赏;吴从从;陈晋荣;程奕涵;张书圣
58 一种多功能磁性DNA纳米球及其制备方法与应用 专利 郭英姝;王玉洁;李双;张书圣
59 一种基于鲁米诺功能化的磁性免疫探针检测甲胎蛋白的方法 专利 李雪梅;郭英姝;张书圣
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