基于FRET技术的两级响应基因干预/检测一体化载体的构建及其在肿瘤治疗中的作用

31870943
2018
C1002.生物材料与生物效应
薛巍
面上项目
研究员
暨南大学
59万元
响应性释放;RNA干扰;自组装;诊断-治疗一体化
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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3 Biomimetic magnetofluorescent ferritin nanoclusters for magnetic resonance and fluorescence-dual modal imaging and targeted tumor therapy 期刊论文 Song Rongguang;Ruan Miaoliang;Dai Jian;Xue Wei
4 Transforming sustained release into on-demand release: self-healing guanosine-borate supramolecular hydrogels with multiple responsiveness for Acyclovir delivery 期刊论文 Wu Cheng-guang;Wang Xiang;Shi Yun-feng;Wang Bin-cheng;Xue Wei;Zhang Yi
5 Lignin Nanoparticles: Green Synthesis in a gamma-Valerolactone/Water Binary Solvent and Application to Enhance Antimicrobial Activity of Essential Oils 期刊论文 Chen Liheng;Shi Yunfeng;Gao Bo;Zhao Yilun;Jiang Yueming;Zha Zhengang;Xue Wei;Gong Liang
6 Density functional theory-guided drug loading strategy for sensitized tumor-homing thermotherapy 期刊论文 Huo Cong-Min;Chen Liheng;Wang Hai-Yang;Luo Si-Man;Wang Xiang;Shi Yun-Feng;Zhu Jing-Yi;Xue Wei
7 Self-activated in vivo therapeutic cascade of erythrocyte membrane-cloaked iron-mineralized enzymes 期刊论文 Liu Wen;Ruan Miao-Liang;Liu Lamei;Ji Xin;Ma Yandong;Yuan Pengfei;Tang Guoheng;Lin Hongsheng;Dai Jian;Xue Wei
8 Advanced biomimetic nanoreactor for specifically killing tumor cells through multi-enzyme cascade 期刊论文 Liu Wen;Wu Jinpei;Ji Xin;Ma Yandong;Liu Lamei;Zong Xiaoqing;Yang Haiyuan;Dai Jian;Chen Xiaoyuan;Xue Wei
9 TMPyP-bound guanosine-borate supramolecular hydrogel as smart hemoperfusion device with real-time visualized/electrochemical bi-modal monitoring for selective blood lead elimination 期刊论文 Xiang Wang;Xin Yan;Bin-cheng Wang;Wei Xue;Chang-ren Zhou;Yi Zhang;Zong-hua Liu
10 一种含有透明质酸的醇脂质体的透皮给药系统及其制备方法与应用 专利 薛巍;马栋;吉玉洁
11 NIR-Laser-Controlled Hydrogen-Releasing PdH Nanohydride for Synergistic Hydrogen-Photothermal Antibacterial and Wound-Healing Therapies 期刊论文 Yu Siming;Li Guowei;Zhao Penghe;Cheng Qikun;He Qianjun;Ma Dong;Xue Wei
12 Dextran methacrylate hydrogel microneedles loaded with doxorubicin and trametinib for continuous transdermal administration of melanoma 期刊论文 Huang Shanghui;Liu Huiling;Huang Shaoshan;Fu Tingling;Xue Wei;Guo Rui
13 Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing 期刊论文 Huilong Guo;Shan Huang;Anding Xu;Wei Xue
14 In Situ Cell Membrane Fusion for Engineered Tumor Cells by Worm-like Nanocell Mimics 期刊论文 Ji Xin;Ma Yandong;Liu Wen;Liu Lamei;Yang Haiyuan;Wu Jinpei;Zong Xiaoqing;Dai Jian;Xue Wei
15 Light-activated nitric-oxide overproduction theranostic nanoplatform based on long-circulating biomimetic nanoerythrocyte for enhanced cancer gas therapy 期刊论文 Wu Chengguang;Liang Jinglan;Wang Xiang;Zhou Xiaoyan;Cai Xiang;Xu Jun;Wang Meng;Wang Wenbo;Ma Dong;Xue Wei
16 Near-infrared laser-controlled nitric oxide-releasing gold nanostar/hollow polydopamine Janus nanoparticles for synergistic elimination of methicillin-resistant Staphylococcus aureus and wound healing 期刊论文 Zhuoying Liang;Wenkang Liu;Ziqiang Wang;Peilian Zheng;Wei Liu;Jianfu Zhao;Yunlong Zhong;Yan Zhang;Jing Lin;Wei Xue;Siming Yu
17 内源性超支化聚精胺阳离子基因载体及其制备方法与应用 专利 薛巍;纪鑫;马栋;郭会龙
18 具有多重响应功能的水凝胶及其制备方法和用途 专利 薛巍;张洁玲;马栋;王永周
19 Role of charge-reversal in the hemo/immuno-compatibility of polycationic gene delivery systems 期刊论文 Yang Qi;Liu Shuo;Liu Xin;Liu Zonghua;Xue Wei;Zhang Yi
20 Artificial Nanoplatelets Depend on Size for Precisely Inducing Thrombosis in Tumor Vessels 期刊论文 Xiaoqing Zong;Lamei Liu;Haiyuan Yang;Jinpei Wu;Pengfei Yuan;Xinjie Chen;Caiqi Yang;Xiaodi Li;Yuchao Li;Xin Ji;Changzheng Shi;Wei Xue;Jian Dai
21 Injectable and Self-Healing Hydrogels with Double-Dynamic Bond Tunable Mechanical, Gel-Sol Transition and Drug Delivery Properties for Promoting Periodontium Regeneration in Periodontitis 期刊论文 Guo Huilong;Huang Shan;Yang Xuanfan;Wu Jianping;Kirk Thomas Brett;Xu Jiake;Xu Anding;Xue Wei
22 Near infrared II laser controlled free radical releasing nanogenerator for synergistic nitric oxide and alkyl radical therapy of breast cancer 期刊论文 Wu Weiwei;Yang Yan;Liang Zhuoying;Song Xiling;Huang Yadong;Qiu Lin;Qiu Xiaozhong;Yu Siming;Xue Wei
23 New insight into lignin aggregation guiding efficient synthesis and functionalization of a lignin nanosphere with excellent performance 期刊论文 Chen Liheng;Luo Si-Man;Huo Cong-Min;Shi Yun-Feng;Feng Jun;Zhu Jing-Yi;Xue Wei;Qiu Xueqing
24 Multifunctional Parachute-like Nanomotors for Enhanced Skin Penetration and Synergistic Antifungal Therapy 期刊论文 Xin Ji;Haiyuan Yang;Wen Liu;Yandong Ma;Jinpei Wu;Xiaoqing Zong;Pengfei Yuan;Xinjie Chen;Caiqi Yang;Xiaodi Li;Hongsheng Lin;Wei Xue;Jian Dai
25 Mitochondria-targeted magnetic gold nanoheterostructure for multi-modal imaging guided photothermal and photodynamic therapy of triple-negative breast cancer 期刊论文 Bo Li;Qian Zhou;Haiyang Wang;Yongchao Zha;Peilian Zheng;Tong Yang;Dong Ma;Lin Qiu;Ximing Xu;Ye Hu;Anna Roig;Siming Yu;Wei Xue
26 Chitosan-graft-Poly(L-lysine) Dendron-Assisted Facile Self-Assembly of Au Nanoclusters for Enhanced X-ray Computer Tomography Imaging and Precise MMP-9 Plasmid shRNA Delivery 期刊论文 Yu Siming;Wen Rong;Wang Haiyang;Zha Yongchao;Qiu Lin;Li Bo;Xue Wei;Ma Dong
27 Codelivery of epigallocatechin-3-gallate and diallyl trisulfide by near-infrared light-responsive mesoporous polydopamine nanoparticles for enhanced antitumor efficacy 期刊论文 Zhou Xiaoyan;Liang Jinglan;Liu Qunfeng;Huang Dequn;Xu Jiake;Gu Heng;Xue Wei
28 Facile One-Pot Synthesis of Meteor Hammer-like Au-MnO x Nanozymes with Spiky Surface for NIR-II Light-Enhanced Bacterial Elimination 期刊论文 Li Xiaonan;Siman Luo;Yu Chen;Yucheng Zuo;Yue Huang;Hong Zhang;Liheng Chen;Jun Feng;Jing-Yi Zhu;Xue Wei
29 Mild-Temperature Photothermal Effect Triggers Simultaneous Nitric Oxide-and Deferoxamine-Releasing Mesoporous Polydopamine-Based Nanoplatform for Robust Antibacterial, Anti-inflammation, and Wound-Healing Activity 期刊论文 Liu Wenkang ;Xiling Song;Wei Liu;Qi Lin;Rui Xu;Hui Li;Xue Wei;Siming Yu
30 Artificial M2 macrophages for disease-modifying osteoarthritis therapeutics 期刊论文 Yandong Ma;Haiyuan Yang;Xiaoqing Zong;Jinpei Wu;Xin Ji;Wen Liu;Pengfei Yuan;Xinjie Chen;Caiqi Yang;Xiaodi Li;Yuanfeng Chen;Wei Xue;Jian Dai
31 一种剪切增稠的止血材料的制备方法 专利 薛巍;徐玉英;张奕;吴城广;马昕
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