USP7多重变构调控机制和小分子抑制剂选择性识别机制的结构生物学研究

31900875
2019
C0502.分子生物物理
宋宜辉
青年科学基金项目
副教授
郑州大学
24万元
去泛素化修饰;构象变化;高通量筛选;化合物与蛋白复合物结构;变构调控
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy 期刊论文 Kai Tang;Ya-Hong Wu;Yihui Song;Bin Yu
2 Harnessing the cyclization strategy for new drug discovery 期刊论文 Kai Tang;Shu Wang;Wenshuo Gao;Yihui Song;Bin Yu
3 KRAS Q61H mutation confers acquired resistance to SHP2 inhibition 期刊论文 Yihui Song;Xinyu Yang;Bin Yu
4 Structure-based design, synthesis and biological evaluation of aminopyrazines as highly potent, selective, and cellularly active allosteric SHP2 inhibitors 期刊论文 Kai Tang;Min Zhao;Ya-Hong Wu;Qiong Wu;Shu Wang;Yu Dong;Bin Yu;Yihui Song;Hong-Min Liu
5 Development of a robust HTRF assay with USP7 full length protein expressed in E. coli prokaryotic system for the identification of USP7 inhibitors 期刊论文 Yhui Song;Shu Wang;Min Zhao;Bin Yu
6 组蛋白去甲基化酶LSD1抑制剂临床研究进展 期刊论文 史宇婷;杨欣语;余斌;宋宜辉
7 2022河南省优秀科技论文一等奖 奖励 宋宜辉
8 Structural and Functional Landscape of FAD-Dependent Histone Lysine Demethylases for New Drug Discovery 期刊论文 Yihui Song;Shu Wang;Bin Yu
9 Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials 期刊论文 Yihui Song;Zhao Min;Huiqing Zhang;Bin Yu
10 Targeting SHP2 for Cancer Treatment: Advances and Prospects 专著 Yihui Song;Bin Yu
11 Repurposing antidepressants for anticancer drug discovery 期刊论文 Yihui Song;Xiaoke Yang;Bin Yu
12 Annual review of lysine-specific demethylase 1 (LSD1/KDM1A) inhibitors in 2021 期刊论文 Yihui Song;Huiqing Zhang;Xiaoke Yang;Yuting Shi;Bin Yu
13 A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors 期刊论文 Yihui Song;Min Zhao;Yahong Wu;Bin Yu;Hong-min Liu
14 Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy 期刊论文 Yihui Song;Shu Wang;Mingxia Zhao;Xiangbo Yang;Bin Yu
15 Combining EGFR inhibitors with SHP2 or LSD1 inhibitors to overcomemultidrug resistance in cancer 期刊论文 Huiqing Zhang;Xinyu Yang;Yihui Song;Bin Yu
16 二氟苯环丙胺类化合物及其制备方法和应用 专利 余斌;宋宜辉;袁硕;张慧青;李中华;刘慧
17 靶向蛋白非催化功能的药物开发新策略 期刊论文 杨欣语;宋宜辉;余斌
18 Crystallographic landscape of SHP2 provides molecular insights for SHP2 targeted drug discovery 期刊论文 Yihui Song;Xin-Yu Yang;Shu Wang;Min Zhao;Hong-Min Liu
19 小檗碱类化合物在制备抗肿瘤药物中的应用 专利 刘宏民;余斌;宋宜辉;张静雅;张慧青;陈小兵;王赛琪
20 吡唑并六元氮杂环类化合物及其合成方法和应用 专利 刘宏民;余斌;宋宜辉;唐凯;王姝
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