TIGIT/CD226与其配体PVR竞争结合的分子机制研究
31700677
2017
C0502.分子生物物理
赵文珊
青年科学基金项目
副教授
郑州大学
24万元
相互作用;TIGIT/CD226;同源建模;PVR;复合物
2018-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD) | 期刊论文 | Du Jiangfeng;Qin Yaping;Wu Yahong;Zhao Wenshan;Zhai Wenjie;Qi Yuanming;Wang Chuchu;Gao Yanfeng |
| 2 | Intrinsic Expression of Immune Checkpoint Molecule TIGIT Could Help Tumor Growth in vivo by Suppressing the Function of NK and CD8( ) T Cells | 期刊论文 | Zhou Xiu Man;Li Wan Qiong;Wu Ya Hong;Han Lu;Cao Xin Guang;Yang Xuan Ming;Wang Hong Fei;Zhao Wen Shan;Zhai Wen Jie;Qi Yuan Ming;Gao Yan Feng |
| 3 | Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR | 期刊论文 | Xiuman Zhou;Jiangfeng Du;Hongfei Wang;Chunxia Chen;Ling Jiao;Xiangrui Cheng;Xiaowen Zhou;Shaomeng Chen;Shanshan Gou;Wenshan Zhao;Wenjie Zhai;Junhui Chen;Yanfeng Gao |
| 4 | Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT | 期刊论文 | Xiaowen Zhou;Jiangfeng Du;Xiuman Zhou;Xiaoshuang Niu;Wanqiong Li;Chunxia Chen;Sifan Lv;Aijun Wu;Shanshan Gou;Yixuan Sun;Wenjie Zhai;Lu Qiu;Yuanming Qi;Wenshan Zhao;Yanfeng Gao |
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