CHCHD2基因突变导致帕金森病的机制研究
81901300
2019
H0912.神经退行性变及相关疾病
毛澄源
青年科学基金项目
主治医师
郑州大学
21万元
CHCHD2;诱导多能干细胞;帕金森病;CHCHD10;点突变小鼠模型
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 一个线粒体脑肌病家系临床表型及遗传学分析 | 期刊论文 | 范丽媛;毛澄源;秦洁;史长河;郑惠敏;胡新超;张槊;胡正威;范雨;董亚丽;杨靖;许予明 |
| 2 | 帕金森病与血清尿酸、同型半胱氨酸水平的相关性研究 | 期刊论文 | 王台;史长河;毛澄源;张书语;范丽媛;范雨;郑惠敏;杨靖;张槊;胡正威;许予明 |
| 3 | A Chinese Han pedigree with Huntington disease mimicking spinocerebellar ataxia | 期刊论文 | Chengyuan Mao;Yun Su;Huiyun Wang;Liyuan Fan;Huimin Zheng;Tai Wang;Xinwei Li;Shuo Zhang;Zhengwei Hu;Haiyang Luo;Jing Yang;Changhe Shi;Yuming Xu |
| 4 | Spinocerebellar Ataxia Type 10 with Atypical Clinical Manifestation in Han Chinese | 期刊论文 | Chengyuan Mao;Xinwei Li;Yun Su;Haiyang Luo;Liyuan Fan;Huimin Zheng;Yu Fan;Zhihua Yang;Shuo Zhang;Zhengwei Hu;Xiaoyan Hao;Changhe Shi;Yuming Xu |
| 5 | 一个发作性运动诱发性运动障碍家系的遗传学诊断 | 期刊论文 | 胡新超;毛澄源;史长河;范丽媛;张槊;胡正威;杨志华;范雨;杨靖;许予明 |
| 6 | Modeling Parkinson's Disease Using Induced Pluripotent Stem Cells | 期刊论文 | Xinchao Hu;Chengyuan Mao;Liyuan Fan;Haiyang Luo;Zhengwei Hu;Shuo Zhang;Zhihua Yang;Huimin Zheng;Huifang Sun;Yu Fan;Jing Yang;Changhe Shi;Yuming Xu |
| 7 | 表现为单纯痉挛性截瘫的青少年型Krabbe病一例遗传及临床分析 | 期刊论文 | 董亚丽;毛澄源;范雨;李梦杰;吴军;许予明;史长河 |
| 8 | CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson’s disease | 期刊论文 | Zhengwei Hu;Chengyuan Mao;Hui Wang;Zhongxian Zhang;Shuo Zhang;Haiyang Luo;Mibo Tang;Jing Yang;Yanpeng Yuan;Yanlin Wang;Yutao Liu;Liyuan Fan;Qimeng Zhang;Dabao Yao;Fen Liu;Jonathan C. Schisler;Changhe Shi;Yuming Xu |
| 9 | Generation of induced pluripotent stem cell line (ZZUi0021-A) from a patient with spinocerebellar ataxia type 19 | 期刊论文 | Fen Liu;Yu Fan;Liyuan Fan;Mengjie Li;Qimeng Zhang;Chengyuan Mao;Jun Wu;Shuo Zhang;Zhengwei Hu;Changhe Shi;Yuming Xu |
| 10 | 神经遗传变性病的精准诊断与应用 | 奖励 | 许予明;史长河;杨靖;宋波;毛澄源;王燕琳;李玉生;刘玉涛;孙石磊;骆海洋;张槊;杨志华;唐秘博;胡正威;范雨 |
| 11 | Association Analysis of 15 GWAS-linked Loci with Parkinson's Disease in Chinese Han Population | 期刊论文 | Xinchao Hu;Chengyuan Mao;Zhengwei Hu;Zhongxian Zhang;Shuo Zhang;Zhihua Yang;Yu Fan;Liyuan Fan;Huimin Zheng;Jing Yang;Yutao Liu;Yanpeng Yuan;Yaohe Wang;Changhe Shi;Yuming Xu |
| 12 | CHCHD2 p. Thr61Ile knock‐in mice exhibit motor defects and neuropathological features of Parkinson's disease | 期刊论文 | Liyuan Fan;Shuo Zhang;Xinwei Li;Zhengwei Hu;Jing Yang;Shuyu Zhang;Huimin Zheng;Yun Su;Haiyang Luo;Xinjing Liu;Yu Fan;Huifang Sun;Zhongxian Zhang;Jinxin Miao;Bo Song;Zongping Xia;Changhe Shi;Chengyuan Mao;Yuming Xu |
| 13 | 1例表现为亚急性起病伴肌张力下降等不典型症状的肝豆状核变性 | 期刊论文 | 郑惠敏;毛澄源;秦洁;史长河;范丽媛;王台;骆海洋;张槊;胡正威;范雨;杨靖;许予明 |
| 14 | Deciphering Neurodegenerative Diseases Using Long-Read Sequencing | 期刊论文 | Yun Su;Liyuan Fan;Changhe Shi;Tai Wang;Huimin Zheng;Haiyang Luo;Shuo Zhang;Zhengwei Hu;Yu Fan;Yali Dong;Jing Yang;Chengyuan Mao;Yuming Xu |
| 15 | α-Synuclein in Parkinson’s Disease: Does a Prion-Like Mechanism of Propagation from Periphery to the Brain Play a Role? | 期刊论文 | Huimin Zheng;Changhe Shi;Haiyang Luo;Liyuan Fan;Zhi-hua Yang;Xinchao Hu;Zhongxian Zhang;Shuo Zhang;Zhengwei Hu;Yu Fan;Jing Yang;Chengyuan Mao;Yuming Xu |
| 16 | Increased PRR14 and VCAM-1 level in serum of patients with Parkinson's disease | 期刊论文 | Huimin Zheng;Tai Wang;Changhe Shi;Liyuan Fan;Yun Su;Yu Fan;Xinwei Li;Jing Yang;Chengyuan Mao;Yuming Xu |
| 17 | New Insights Into the Pathogenesis of Alzheimer's Disease | 期刊论文 | Liyuan Fan;Chengyuan Mao;Xinchao Hu;Shuo Zhang;Zhi-hua Yang;Zhengwei Hu;Huifang Sun;Yu Fan;Yali Dong;Jing Yang;Changhe Shi;Yuming Xu |
| 18 | Neuroinflammation in Parkinson’s Disease: Triggers, Mechanisms, and Immunotherapies | 期刊论文 | Tai Wang;Changhe Shi;Haiyang Luo;Huimin Zheng;Liyuan Fan;Mibo Tang;Yun Su;Jing Yang;Chengyuan Mao;Yuming Xu |
| 19 | 一个以高血压、骨折为首发症状的Ⅰ型神经纤维瘤病家系分析 | 期刊论文 | 苏赟;毛澄源;秦小飞;单迎光;史长河;范丽媛;董亚丽;郑惠敏;李心蔚;张槊;胡正威;杨靖;许予明 |
| 20 | Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population | 期刊论文 | Liyuan Fan;Changhe Shi;Xinchao Hu;Zhongxian Zhang;Huimin Zheng;Haiyang Luo;Yu Fan;Shuo Zhang;Zhengwei Hu;Jing Yang;Chengyuan Mao;Yuming Xu |
| 21 | Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson’s disease | 期刊论文 | Yun Su;Changhe Shi;Tai Wang;Chen Liu;Jing Yang;Shuyu Zhang;Liyuan Fan;Huimin Zheng;Xinwei Li;Haiyang Luo;Shuo Zhang;Zhengwei Hu;Yu Fan;Xiaoyan Hao;Chenglin Zhang;Bo Song;Chengyuan Mao;Yuming Xu |
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