以血凝素蛋白保守功能区为新靶点的小分子天然来源流感病毒进入抑制剂研究

U1301224
2013
C0505.蛋白质、多肽与酶生物化学
刘叔文
联合基金项目
教授
南方医科大学
260万元
流感病毒;病毒进入抑制剂;先导化合物;血凝素;天然药物分子
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Targeting pattern-recognition receptors to discover new small molecule immune modulators 期刊论文 Zhu G;Xu Y;Cen X;Nandakumar KS;Liu S;Cheng K
2 A new role of neuraminidase (NA) in the influenza virus life cycle: implication for developing NA inhibitors with novel mechanism of action 期刊论文 Yang Jie;Liu Shuwen;Du Lanying;Jiang Shibo
3 Oligothiophene compounds inhibit the membrane fusion between H5N1 avian influenza virus and the endosome of host cell 期刊论文 Zhu Zhibo;Yao Zhili;Shen Xiantian;Chen Zhipeng;Liu Xiangtao;Parquette Jon R.;Liu Shuwen
4 New influenza A virus entry inhibitors derived from the viral fusion peptides 期刊论文 Wu Wenjiao;Lin Dongguo;Shen Xintian;Li Fangfang;Fang Yuxin;Li Kaiqun;Xun Tianrong;Yang Guang;Yang Jie;Liu Shuwen;He Jian
5 Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway 期刊论文 Yi Ding;Lizhu Chen;Wenjiao Wu;Jie Yang;Zifeng Yang;Shuwen Liu
6 Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action 期刊论文 Li Richan;Liu Teng;Liu Miaomiao;Chen Feimin;Liu Shuwen;Yang Jie
7 Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry 期刊论文 Wu Wenjiao;Li Richan;Li Xianglian;He Jian;Jiang Shibo;Liu Shuwen;Yang Jie
8 Discovery of 3-O-beta-chacotriosyl oleanane-type triterpenes as H5N1 entry inhibitors 期刊论文 Song Gaopeng;Shen Xintian;Li Sumei;Si Hongzong;Li Yibin;Luan Haiye;Fan Jihong;Liang Qianqian;Liu Shuwen
9 马铃薯三糖五环三萜类化合物体外抗H5N1流感病毒的活性评价 期刊论文 宋高鹏;申新田;李素梅;黎奕斌;范继鸿;梁倩倩;刘叔文
10 一种低聚噻吩衍生物及其应用 专利 朱志博;刘叔文;申新田
11 A "building block" approach to the new influenza A virus entry inhibitors with reduced cellular toxicities 期刊论文 Lin Dongguo;Li Fangfang;Wu Qiuyi;Xie Xiangkun;Wu Wenjiao;Wu Jie;Chen Qing;Liu Shuwen;He Jian
12 "On-Water" Facile Synthesis of Novel Pyrazolo[3,4-b]pyridinones Possessing Anti-influenza Virus Activity 期刊论文 Zeng Li-Yan;Liu Teng;Yang Jie;Yang Yueli;Cai Chun;Liu Shuwen
13 具有抗菌抗病毒活性的小分子肽及其活性修饰物 专利 何坚;刘叔文;林冬果;方堉欣;王静瑜
14 一种吡啶并吡唑酮类衍生物及其抗甲型流感病毒方面的应用 专利 杨洁;刘叔文
15 快速方便地检测淀粉样蛋白形成的荧光探针及方法 专利 何坚;林冬果;刘叔文
16 Investigational hemagglutinin-targeted influenza virus inhibitors 期刊论文 Zeng Li-Yan;Yang Jie;Liu Shuwen
17 埃博拉病毒的防治进展 期刊论文 武文姣;刘叔文
18 马铃薯三糖熊果酸衍生物抑制H5N1流感病毒进入靶细胞 期刊论文 宋高鹏;申新田;黎奕斌;郑宇珊;熊平;刘叔文
19 Super short membrane-active lipopeptides inhibiting the entry of influenza A virus 期刊论文 Wu Wenjiao;Wang Jingyu;Lin Dongguo;Chen Linqing;Xie Xiangkun;Shen Xintian;Yang Qingqing;Wu Qiuyi;Yang Jie;He Jian;Liu Shuwen
20 The Drug Targets and Antiviral Molecules for Treatment of Ebola Virus Infection 期刊论文 Wu Wenjiao;Liu Shuwen
21 Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action 期刊论文 Fang Yuxin;Zhong Wenjing;Wang Yue;Xun Tianrong;Lin Dongguo;Liu Wenjun;Wang Jingyu;Lv Lin;Liu Shuwen;He Jian
22 石斛碱在制备抗流感病毒药物中的应用 专利 杨洁;刘叔文;李日婵
23 Potent influenza A virus entry inhibitors targeting a conserved region of hemagglutinin 期刊论文 Lin Dongguo;Luo Yinzhu;Yang Guang;Li Fangfang;Xie Xiangkun;Chen Daiwei;He Lifang;Wang Jingyu;Ye Chunfeng;Lu Shengsheng;Lv Lin;Liu Shuwen;He Jian
24 Structure-activity relationships of 3-O-beta-chacotriosyl oleanane-type triterpenoids as potential H5N1 entry inhibitors 期刊论文 Song Gaopeng;Shen Xintian;Li Sumei;Li Yibin;Si Hongzong;Fan Jihong;Li Junhua;Gao Erqiang;Liu Shuwen
25 A "building block" approach to the new influenza A virus entry inhibitors with reduced cellular toxicities 期刊论文 Lin Dongguo;Li Fangfang;Wu Qiuyi;Xie Xiangkun;Wu Wenjiao;Wu Jie;Chen Qing;Liu Shuwen;He Jian
26 "On-Water" Facile Synthesis of Novel Pyrazolo[3,4-b]pyridinones Possessing Anti-influenza Virus Activity 期刊论文 Zeng Li-Yan;Liu Teng;Yang Jie;Yang Yueli;Cai Chun;Liu Shuwen
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