PCNA磷酸化诱导基因突变与癌症发生的机理
31370766
2013
C0505.蛋白质、多肽与酶生物化学
李国民
面上项目
教授
清华大学
90万元
错配修复;PCNA磷酸化;微卫星不稳定;;
2014-01至2017-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Functional Analysis of the Role of Phosphorylated PCNA in Cancer Development and its Potential in Cancer Therapy | 会议 | Ortega, Janice|Gu, Liya|Dai, Junbiao|Li, Guo-Min| |
| 2 | Arsenic Inhibits DNA Mismatch Repair by Promoting EGFR Expression and PCNA Phosphorylation | 期刊 | Tong Dan;Ortega Janice;Kim Christine;Huang Jian;Gu Liya;Li Guo-Min |
| 3 | Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis | 期刊 | Gu, Liya|Gu, Liya|Li, Guo-Min|Li, Guo-Min| |
| 4 | MutS beta promotes trinucleotide repeat expansion by recruiting DNA polymerase beta to nascent (CAG)(n) or (CTG)(n) hairpins for error-prone DNA synthesis | 期刊 | Leffak, Michael|Leffak, Michael|Li, Guo-Min|Li, Guo-Min| |
| 5 | Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells | 期刊 | Li, Feng|Ortega, Janice|Gu, Liya|Li, Guo-Min| |
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