代谢性核受体在线粒体、内质网应激对细胞能量代谢的调控
30890044
2008
H0220.循环系统疾病研究新技术与新方法
张辰宇
重大项目
教授
南京大学
260万元
代谢性核受体；线粒体；内质网应激；PGC1a；ATF6
2009-01至2012-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system | 期刊论文 | Tang Rui;Li Limin;Zhu Dihan;Hou Dongxia;Cao Ting;Gu Hongwei;Zhang Jing;Chen Junyuan;Zhang Chen-Yu;Zen Ke |
| 2 | A Microarray-based Approach Identifies ADP Ribosylation Factor-like Protein 2 as a Target of microRNA-16 | 期刊论文 | Wang Kehui;Li Peng;Dong Yanye;Cai Xing;Hou Dongxia;Guo Jigang;Yin Yuan;Zhang Yujing;Li Jing;Liang Hongwei;Yu Bowen;Chen Jiangning;Zen Ke;Zhang Junfeng;Zhang Chen-Yu;Chen Xi |
| 3 | PGC-1 alpha Is a Key Regulator of Glucose-Induced Proliferation and Migration in Vascular Smooth Muscle Cells | 期刊论文 | Zhu Lingyun;Sun Guoxun;Zhang Hongjie;Zhang Yan;Chen Xi;Jiang Xiaohong;Jiang Xueyuan;Krauss Stefan;Zhang Junfeng;Xiang Yang;Zhang Chen-Yu |
| 4 | The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1 alpha expression | 期刊论文 | Xu Wei;Guo Ting;Zhang Yan;Jiang Xiaohong;Zhang Yongxian;Zen Ke;Yu Bo;Zhang Chen-Yu |
| 5 | Secreted microRNAs: a new form of intercellular communication | 期刊论文 | Chen, Xi|Liang, Hongwei|Zhang, Junfeng|Zen, Ke|Zhang, Chen-Yu| |
| 6 | Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA | 期刊论文 | Zhang Lin;Hou Dongxia;Chen Xi;Li Donghai;Zhu Lingyun;Zhang Yujing;Li Jing;Bian Zhen;Liang Xiangying;Cai Xing;Yin Yuan;Wang Cheng;Zhang Tianfu;Zhu Dihan;Zhang Dianmu;Xu Jie;Chen Qun;Ba Yi;Liu Jing;Wang Qiang;Chen Jianqun;Wang Jin;Wang Meng;Zhang Qipeng;Zhang Junfeng;Zen Ke;Zhang Chen-Yu |
| 7 | Protective Role of Estrogen-induced miRNA-29 Expression in Carbon Tetrachloride-induced Mouse Liver Injury | 期刊论文 | Zhang Yaqin;Wu Linping;Wang Yang;Zhang Mingcao;Li Limin;Zhu Dihan;Li Xihan;Gu Hongwei;Zhang Chen-Yu;Zen Ke |
| 8 | The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation | 期刊论文 | Li Li;Wang Xu;Chen Jing;Ding Hong;Zhang Yu;Hu Tian-cen;Hu Li-hong;Jiang Hua-liang;Shen Xu |
| 9 | 7-Chloroarctinone-b as a new selective PPAR gamma antagonist potently blocks adipocyte differentiation | 期刊论文 | Li Yong-tao;Li Li;Chen Jing;Hu Tian-cen;Huang Jin;Guo Yue-wei;Jiang Hua-liang;Shen Xu |
| 10 | Molecular Determinants of Magnolol Targeting Both RXR alpha and PPAR gamma | 期刊论文 | Zhang Haitao;Xu Xing;Chen Lili;Chen Jing;Hu Lihong;Jiang Hualiang;Shen Xu |
| 11 | Structural Basis for Retinoic X Receptor Repression on the Tetramer | 期刊论文 | Lili Chen|Haitao Zhang|Jing Chen|Hualiang Jiang|Xu Shen| |
| 12 | Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis | 期刊论文 | Zen Ke;Guo Ya-Lan;Li Li-Min;Bian Zhen;Zhang Chen-Yu;Liu Yuan |
| 13 | Discovery and Optimization of 1,3,4-Trisubstituted-pyrazolone Derivatives as Novel, Potent, and Nonsteroidal Farnesoid X Receptor (FXR) Selective Antagonists | 期刊论文 | Huang Huang;Yu Ying;Gao Zhenting;Zhang Yong;Li Chenjing;Xu Xing;Jin Hui;Yan Wenzhong;Ma Ruoqun;Zhu Jin;Shen Xu;Jiang Hualiang;Chen Lili;Li Jian |
| 14 | Discovery of new non-steroidal FXR ligands via a virtual screening workflow based on Phase shape and induced fit docking | 期刊论文 | Fu, Jing|Si, Pei|Zheng, Mingyue|Chen, Lili|Shen, Xu|Tang, Yun|Li, Weihua| |
| 15 | Regulation of mammalian gene expression by exogenous microRNAs | 期刊论文 | Liang, Hongwei|Huang, Lei|Cao, Jingjing|Zen, Ke|Chen, Xi|Zhang, Chen-Yu| |
| 16 | Danthron Functions as a Retinoic X Receptor Antagonist by Stabilizing Tetramers of the Receptor | 期刊论文 | Zhang Haitao;Zhou Rong;Li Li;Chen Jing;Chen Lili;Li Chenjing;Ding Hong;Yu Liang;Hu Lihong;Jiang Hualiang;Shen Xu |
| 17 | Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance | 期刊论文 | Tang Xuan;Zhuang Jingjing;Chen Jing;Yu Liang;Hu Lihong;Jiang Hualiang;Shen Xu |
| 18 | Activating transcription factor 6 protects insulin receptor from ER stress-stimulated desensitization via p42/44 ERK pathway | 期刊论文 | Tang Xuan;Shen Hong;Chen Jing;Wang Xu;Zhang Yu;Chen Li-li;Rukachaisirikul Vatcharin;Jiang Hua-liang;Shen Xu |
| 19 | The evolutionary trajectory of mitochondrial carrier family during metazoan evolution | 期刊论文 | Gong Ming;Li Jie;Wang Meng;Wang Jin;Zen Ke;Zhang Chen-Yu |
| 20 | Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients | 期刊论文 | Lingyun Zhu;Qiang Wang;Lin Zhang;Zhixiang Fang;Fang Zhao;Zhiyuan Lv;Zuguang Gu;Junfeng Zhang;Jin Wang;Ke Zen;Yang Xiang;Dongjin Wang;Chen-Yu Zhang |
| 21 | Activation of Protein Serine/Threonine Phosphatase PP2C alpha Efficiently Prevents Liver Fibrosis | 期刊论文 | Wang Lirui;Wang Xu;Chen Jing;Yang Zhengyi;Yu Liang;Hu Lihong;Shen Xu |
| 22 | InterMitoBase: An annotated database and analysis platform of protein-protein interactions for human mitochondria | 期刊论文 | Gu Zuguang;Li Jie;Gao Song;Gong Ming;Wang Junling;Xu Hua;Zhang Chenyu;Wang Jin |
| 23 | The protective role of peroxisome proliferator-activated receptor gamma coactivator-1 alpha in hyperthyroid cardiac hypertrophy | 期刊论文 | Xu Wei;Hou Dongxia;Jiang Xiangrui;Lu Zhiyuan;Guo Ting;Liu Yuan;Wang Dongjin;Zen Ke;Yu Bo;Zhang Chen-Yu |
| 24 | Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways | 期刊论文 | Liu Qiong;Zhang Yu;Lin Zhonghui;Shen Hong;Chen Lili;Hu Lihong;Jiang Hualiang;Shen Xu |
| 25 | (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice | 期刊论文 | Zhang Yu;Zhang Haitao;Yao Xin-gang;Shen Hong;Chen Jing;Li Chenjing;Chen Lili;Zheng Mingyue;Ye Jiming;Hu Lihong;Shen Xu;Jiang Hualiang |
| 26 | MicroRNA-30a Sensitizes Tumor Cells to cis-Platinum via Suppressing Beclin 1-mediated Autophagy | 期刊论文 | Zou Zhenyou;Wu Linping;Ding Hanying;Wang Yang;Zhang Yaqin;Chen Xuejiao;Chen Xi;Zhang Chen-Yu;Zhang Qipeng;Zen Ke |
| 27 | Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis | 期刊论文 | Chen Xi;Hu Zhibin;Wang Wenjing;Ba Yi;Ma Lijia;Zhang Chunni;Wang Cheng;Ren Zhiji;Zhao Yang;Wu Sijia;Zhuang Rui;Zhang Yixin;Hu Heng;Liu Chazhen;Xu Lin;Wang Jun;Shen Hongbing;Zhang Junfeng;Zen Ke;Zhang Chen-Yu |
| 28 | Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions | 期刊论文 | Lili Chen |Jin Zhu |Jian Li |Ruoqun Ma |Xu Shen |Jie Liu |Hualiang Jiang | |
| 29 | Small molecules from natural sources, targeting signaling pathways in diabetes | 期刊论文 | Lili Chen|Qiong Liu|Lihong Hu|Xu Shen|Yuewei Guo| |
| 30 | Structure Basis of Bigelovin as a Selective RXR Agonist with a Distinct Binding Mode | 期刊论文 | Zhang Haitao;Li Li;Chen Lili;Hu Lihong;Jiang Hualiang;Shen Xu |
| 31 | Urinary MicroRNA-10a and MicroRNA-30d Serve as Novel, Sensitive and Specific Biomarkers for Kidney Injury | 期刊论文 | Wang, Nan|Zhou, Yang|Jiang, Lei|Li, Donghai|Yang, Junwei|Zhang, Chen-Yu|Zen, Ke| |
| 32 | L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases beta-amyloid peptide production in HEK293-APPswe cells | 期刊论文 | Lu Qin;Chen Wu-yan;Zhu Zhi-yuan;Chen Jing;Xu Ye-chun;Kaewpet Morakot;Rukachaisirikul Vatcharin;Chen Li-li;Shen Xu |
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