内质网氧化还原稳态在高同型半胱氨酸血症引起血管内皮细胞功能损伤中的作用
31771261
2017
C1106.衰老与生物节律
王磊
面上项目
研究员
中国科学院生物物理研究所
59万元
血管内皮细胞;氧化应激;同型半胱氨酸;内质网应激;氧化还原稳态
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1 alpha | 期刊论文 | Zhang Jianchao;Zhu Qinyu;Wang Xi'e;Yu Jiaojiao;Chen Xinxin;Wang Jifeng;Wang Xi;Xiao Junyu;Wang Chih-chen;Wang Lei |
| 2 | Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis | 期刊论文 | Wu Xun;Zhang Lihui;Miao Yutong;Yang Juan;Wang Xian;Wang Chih-chen;Feng Juan;Wang Lei |
| 3 | Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization | 期刊论文 | Chen Xinxin;Zhang Jianchao;Liu Pulan;Wei Yangyang;Wang Xi'e;Xiao Junyu;Wang Chih-chen;Wang Lei |
| 4 | Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1 alpha and protein disulfide isomerase suppresses the progression of cervical cancer | 期刊论文 | Zhang Yini;Li Tao;Zhang Lihui;Shangguan Fugen;Shi Guizhi;Wu Xun;Cui Ya;Wang Xi'e;Wang Xi;Liu Yongzhang;Lu Bin;Wei Taotao;Wang Chih-chen;Wang Lei |
| 5 | Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner. | 期刊论文 | Yan Yu;Wu Xun;Wang Pengcheng;Zhang Songyang;Sun Lulu;Zhao Yang;Zeng GuangYi;Liu Bo;Xu Guoheng;Liu Huiying;Wang Lei;Wang Xian;Jiang Changtao |
| 6 | The b ' domain of protein disulfide isomerase cooperates with the a and a ' domains to functionally interact with platelets | 期刊论文 | Wang Lu;Zhou Junsong;Wang Lei;Wang Chih-chen;Essex David W. |
| 7 | Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. | 期刊论文 | Yu Jiaojiao;Li Tao;Liu Yu;Wang Xi;Zhang Jianchao;Wang Xi’e;Shi Guizhi;Lou Jizhong;Wang Likun;Wang Chih-chen;Wang Lei |
| 8 | Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7 | 期刊论文 | Fang Jingqi;Yang Jiping;Wu Xun;Zhang Gangming;Li Tao;Wang Xi'e;Zhang Hong;Wang Chih-chen;Liu Guang-Hui;Wang Lei |
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