Hedgehog信号通路在肝窦内皮细胞介导血管重构致肝硬化中的调控作用

31571455
2015
C0702.细胞信号转导
郑仕中
面上项目
教授
南京中医药大学
60万元
肝硬化;缺氧诱导因子1α;血管重构;肝窦内皮细胞;Hedgehog通路
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis in vitro and in vivo 期刊论文 Bian M;Chen X;Zhang C;Jin H;Wang F;Shao J;Chen A;Zhang F;Zheng S
2 Dihydroartemisinin counteracts fibrotic portal hypertension via farnesoid X receptor-dependent inhibition of hepatic stellate cell contraction 期刊论文 Xu W;Lu C;Zhang F;Shao J;Yao S;Zheng S
3 lncRNA在慢性肝病中的作用与机制研究进展 期刊论文 王志敏;金欢欢;卞勉励;开钧;杨祥;邵江娟;张峰;郑仕中
4 Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity 期刊论文 Zhang F;Chen L;Jin H;Shao J;Wu L;Lu Y;Zheng S
5 Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism 期刊论文 Chen L;Chen Q;Zhu X;Kong D;Wu L;Shao J;Zheng S
6 Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPAR gamma-dependent manner 期刊论文 He J;Hong B;Bian M;Jin H;Chen J;Shao J;Zhang F;Zheng S
7 Periostin in chronic liver diseases: Current research and future perspectives 期刊论文 Jia Y;Zhong F;Jiang S;Guo Q;Jin H;Wang F;Li M;Wang L;Chen A;Zhang F;Shao J;Zheng S
8 Oroxylin A regulates the turnover of lipid droplet via downregulating adipose triglyceride lipase (ATGL) in hepatic stellate cells. 期刊论文 Zhang Z;Guo M;Shen M;Tan S;Shao J;Zheng S
9 Nrf2 induces lipocyte phenotype via a SOCS3-dependent negative feedback loop on JAK2/STAT3 signaling in hepatic stellate cells 期刊论文 Lu C;Xu W;Shao J;Zhang F;Chen A;Zheng S
10 Dihydroartemisinin prevents liver fibrosis in bile duct ligated rats by inducing hepatic stellate cell apoptosis through modulating the PI3K/Akt pathway 期刊论文 Chen Q;Chen L;Wu X;Zhang F;Jin H;Lu C;Shao J;Kong D;Wu L;Zheng S
11 Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes 期刊论文 Lu C;Xu W;Shao J;Zhang F;Chen A;Zheng S
12 Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells 期刊论文 Wang F;Jia Y;Li M;Wang L;Shao J;Guo Q;Tan S;Ding H;Chen A;Zhang F;Zheng S
13 Oroxylin A inhibits ethanol-induced hepatocyte senescence viaYAP pathway 期刊论文 Jin H;Lian N;Bian M;Zhang C;Chen X;Shao J;Wu L;Chen A;Guo Q;Zhang F;Zheng S
14 Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis 期刊论文 Zhang F;Hao M;Jin H;Yao Z;Lian N;Wu L;Shao J;Chen A;Zheng S
15 Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin-1 signaling 期刊论文 Chen X;Bian M;Jin H;Lian N;Shao J;Zhang F;Zheng S
16 白介素1家族在脂肪肝疾病中的作用及机制研究进展 期刊论文 陈星燃;卞勉励;张晨曦;陆春风;张峰;郑仕中
17 Nrf2 knockdown attenuates the ameliorative effects of ligustrazine on hepatic fibrosis by targeting hepatic stellate cell transdifferentiation 期刊论文 Lu C;Xu W;Zhang F;Shao J;Zheng S
18 Dihydroartemisinin inhibits ER stress-mediated mitochondrial pathway to attenuate hepatocyte lipoapoptosis via blocking the activation of the PI3K/Akt pathway 期刊论文 Chen X;Bian M;Zhang C;Kai J;Yao Z;Jin H;Lu C;Shao J;Chen A;Zhang F;Zheng S
19 Tetramethylpyrazine attenuates sinusoidal angiogenesis via inhibition of hedgehog signaling in liver fibrosis 期刊论文 Zhao S;Zhang Z;Yao Z;Shao J;Chen A;Zhang F;Zheng S
20 肝细胞癌的RNA甲基化修饰 期刊论文 金春;李蒙蒙;李余佳;高俪原;梁宝瑜;王桭屹;张峰;邵江娟;郑仕中
21 Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha 期刊论文 Jin H;Lian N;Bian M;Zhang C;Chen X;Shao J;Wu L;Chen A;Guo Q;Zhang F;Zheng S
22 Interaction between autophagy and senescence is required for dihydroartemisinin to alleviate liver fibrosis 期刊论文 Zhang Z;Yao Z;Zhao S;Shao J;Chen A;Zhang F;Zheng S
23 Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell 期刊论文 Zhang Z;Zhao S;Yao Z;Wang L;Shao J;Chen A;Zhang F;Zheng S
24 铁死亡在肝细胞癌中的作用以及研究进展 期刊论文 王玲;贾岩;李蒙蒙;王飞虾;张自力;张峰;郑仕中
25 Inhibition of YAP signaling contributes to senescence of hepatic stellate cells induced by tetramethylpyrazine 期刊论文 Jin H;Lian N;Zhang F;Bian M;Chen X;Zhang C;Jia Y;Lu C;Hao M;Shao J;Wu L;Chen A;Zheng S
26 Ligand Activation of PPAR gamma by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1 alpha 期刊论文 Zhang F;Lu S;He J;Jin H;Wang F;Wu L;Shao J;Chen A;Zheng S
27 Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-beta R/ERK signaling pathway 期刊论文 Chen Q;Chen L;Kong D;Shao J;Wu L;Zheng S
28 细胞焦亡在慢性肝脏疾病中作用的研究进展 期刊论文 杨祥;开钧;王志敏;张晨曦;邵江娟;张峰;郑仕中
29 Activation of autophagy is required for Oroxylin A to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation 期刊论文 Chen W;Zhang Z;Yao Z;Wang L;Zhang F;Shao J;Chen A;Zheng S
30 双氢青蒿素通过激活Nrf2促进肝星状细胞坏死性凋亡的研究 期刊论文 陆春风;许文萱;张峰;郑仕中
31 Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress 期刊论文 Bian M;He J;Jin H;Lian N;Shao J;Guo Q;Wang S;Zhang F;Zheng S
32 Ligustrazine disrupts lipopolysaccharide-activatedNLRP3 inflammasome pathway associated with inhibition of Toll-like receptor 4in hepatocytes. 期刊论文 Zhang F;Jin H;Wu L;Shao J;Wu X;Lu Y;Zheng S
33 青蒿素衍生物在制备治疗肝纤维化药物中的应用 专利 张峰;郑仕中;陆茵;连娜琦;姜袁圆;熊鑫;段旭酉;金欢欢
34 Diallyl Trisulfide Suppresses Oxidative Stress-Induced Activation of Hepatic Stellate Cells through Production of Hydrogen Sulfide 期刊论文 Zhang F;Jin H;Wu L;Shao J;Zhu Xi;Chen A;Zheng S
35 Blockade of Hedgehog Pathway is Required for the Protective Effects of Magnesium Isoglycyrrhizinate Against Ethanol-induced Hepatocyte Steatosis and Apoptosis 期刊论文 Lu C;Xu W;Shao J;Zhang F;Chen A;Zheng S
36 肝细胞程序性坏死在肝损伤中的研究进展 期刊论文 贾岩;金欢欢;李蒙蒙;王玲;王飞虾;张晨曦;张峰;郑仕中
37 Hepatic stellate cell interferes with NK cell regulation of fibrogenesis via curcumin induced senescence of hepatic stellate cell 期刊论文 Jin H;Jia Y;Yao Z;Huang J;Hao M;Yao S;Lian N;Zhang F;Zhang C;Chen X;Bian M;Shao J;Wu Li;Chen A;Zheng S
38 Nrf2 Knockdown Disrupts the Protective Effect of Curcumin on Alcohol-Induced Hepatocyte Necroptosis 期刊论文 Lu C;Xu W;Zhang F;Shao J;Zheng S
39 细胞外囊泡在慢性肝病中作用的研究进展 期刊论文 王飞虾;李蒙蒙;王玲;贾岩;张峰;郑仕中
40 P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation 期刊论文 Wang L;Zhang Z;Li M;Wang F;Jia Y;Zhang F;Shao J;Chen A;Zheng S
41 Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1 signaling 期刊论文 Zhang C;Bian M;Chen X;Jin H;Zhao S;Yang X;Shao J;Chen A;Guo Q;Zhang F;Zheng S
42 RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells 期刊论文 Zhang Z;Guo M;Li Y;Shen M;Kong D;Shao J;Ding H;Tan S;Chen A;Zhang F;Zheng S
43 Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism 期刊论文 Chen L;Chen Q;Zhu X;Kong D;Wu L;Shao J;Zheng S
44 Dihydroartemisinin Restricts Hepatic Stellate Cell Contraction via an FXR-S1PR2-dependent Mechanism 期刊论文 Xu W;Lu C;Zhang F;Shao J;Zheng S
45 Curcumin Inhibits Aerobic Glycolysis in Hepatic Stellate Cells Associated with Activation of Adenosine Monophosphate-activated Protein Kinase 期刊论文 Lian N;Jin H;Zhang F;Wu L;Shao J;Lu Y;Zheng S
46 ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis 期刊论文 Zhang Z;Guo M;Zhao S;Shao J;Zheng S
47 肝窦内皮细胞在肝脏疾病中的作用 期刊论文 张晨曦;卞勉励;陈星燃;赵士峰;金欢欢;陈琴;张峰;郑仕中
48 Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells 期刊论文 Jia Y;Wang F;Guo Q;Li M;Wang L;Zhang Z;Jiang S;Jin H;Chen A;Tan S;Zhang F;Shao J;Zheng S
49 Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells 期刊论文 Zhang Z;Yao Z;Wang L;Ding H;Shao J;Chen A;Zhang F;Zheng S
50 Lipophagy and liver disease: New perspectives to better understanding and therapy 期刊论文 Zhang Z;Yao Z;Chen Y;Qian L;Jiang S;Zhou J;Shao J;Chen A;Zhang F;Zheng S
51 Activation of PPAR gamma/P53 signaling is required for curcumin to induce hepatic stellate cell senescence 期刊论文 Jin H;Lian N;Zhang F;Chen L;Chen Q;Lu C;Bian M;Shao J;Wu L;Zheng S
52 TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1. 期刊论文 Shao J;Li M;Guo Q;Jin H;Wang F;Zheng S;Wang X
53 Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells 期刊论文 Lu C;Xu W;Zheng S
54 铁死亡的调控机制及其在肝疾病中的作用研究进展 期刊论文 李余佳;王玲;金春;高俪原;梁宝瑜;王桭屹;张峰;郑仕中
55 Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. 期刊论文 Xu W;Lu C;Yao Z;Zhang F;Shao J;Zheng S
56 线粒体功能障碍与慢性肝病 期刊论文 李蒙蒙;贾岩;王飞虾;王玲;张峰;邵江娟;郑仕中
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