PAK1调控人类精原干细胞自我更新与凋亡的作用及分子机制研究

31872845
2018
C1206.生殖细胞及性别决定
何祖平
面上项目
教授
湖南师范大学
60万元
转录与转录后调控;精原干细胞;自我更新与凋亡;PAK1;人
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 人类精原干细胞自我更新与分化为精子细胞的分子机制研究 奖励 何祖平
2 精子发生障碍诊疗关键技术构建及其临床应用 奖励 李铮;何祖平
3 Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes 期刊论文 Wenhui Zhang;Wei Chen;Yinghong Cui;Liping Wen;Qingqing Yuan;Fan Zhou;Qianqian Qiu;Min Sun;Zheng Li;Zuping He
4 The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis 期刊论文 Rui Zhou;Jingrouzi Wu;Bang Liu;Yiqun Jiang;Wei Chen;Jian Li;Quanyuan He;Zuping He
5 The mechanisms and functions of microRNAs in mediating the fate determinations of human spermatogonial stem cells and Sertoli cells 期刊论文 Wei Chen;Yinghong Cui;Minqi Ning;Haorui Zhang;Chenjun Yin;Zuping He
6 MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility 期刊论文 Cailin Wan;Wei Chen;Yinghong Cui;Zuping He
7 MiRNA-31-5p Mediates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells via Targeting JAZF1 and Cyclin A2 期刊论文 Hongyong Fu;Fan Zhou;Qingqing Yuan;Wenhui Zhang;Qianqian Qiu;Xing Yu;Zuping He
8 Novel Gene Regulation in Normal and Abnormal Spermatogenesis 期刊论文 Li Du;Wei Chen;Zixin Cheng;Si Wu;Jian He;Lu Han;Zuping He;Wenbing Qin
9 Characterization, isolation,and culture of spermatogonial stem cells in Macaca fascicularis 期刊论文 Mao Guoping;Niu Minghui;Cui Yinghong;Tang Ruiling;Chen Wei;Liu Bang;He Zuping
10 RNF144B stimulates the proliferation and inhibits the apoptosis of human spermatogonial stem cells via the FCER2/NOTCH2/HES1 pathway and its abnormality is associated with azoospermia 期刊论文 Li Du;Wei Chen;Chunyun Li;Yinghong Cui;Zuping He
11 Hsa-miR-1908-3p mediates the self-renewal and apoptosis of human spermatogonial stem cells via targeting KLFs 期刊论文 Wei Chen;Yinghong Cui;Bang Liu;Chunyun Li;Li Du;Ruiling Tang;Lulu Qin;Yiqun Jiang;Jian Li;Xing Yu;Quanyuan He;Zuping He
12 miRNA-122-5p stimulates the proliferation and DNA synthesis and inhibits the early apoptosis of human spermatogonial stem cells by targeting CBL and competing with lncRNA CASC7 期刊论文 Fan Zhou;Wei Chen;Yinghong Cui;Bang Liu;Qingqing Yuan;Zheng Li;Zuping He
13 Regulation of long non-coding RNAs and circular RNAs in spermatogonial stem cells. 期刊论文 Fan Zhou;Wei Chen;Yiqun Jiang;Zuping He
14 Generation of male germ cells in vitro from the stem cells 期刊论文 Zuping He;Ying-Hong Cui;Wei Chen;Si Wu;Cai-Lin Wan
15 FOXP3 pathogenic variants cause male infertility through affecting the proliferation and apoptosis of human spermatogonial stem cells 期刊论文 Qianqian Qiu;Xing Yu;Chencheng Yao;Yujun Hao;Liqing Fan;Chunyi Li;Peng Xu;Geng An;Zheng Li;Zuping He
16 Hsa-miR-100-3p Controls the Proliferation, DNA Synthesis, and Apoptosis of Human Sertoli Cells by Binding to SGK3 期刊论文 Bang Liu;Yinghong Cui;Wei Chen;Li Du;Chunyun Li;Cailin Wan;Zuping He
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