两种Nav1.9专一性调制剂的作用机制研究和应用探索

31770832
2017
C0505.蛋白质、多肽与酶生物化学
刘中华
面上项目
教授
湖南师范大学
60万元
活性多肽;作用机制;毒素;疼痛;钠通道Nav1.9
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors 期刊论文 Peng Shuijiao;Chen Minzhi;Xiao Zhen;Xiao Xin;Luo Sen;Liang Songping;Zhou Xi;Liu Zhonghua
2 Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain 期刊论文 Zhang Yunxiao;Wang Li;Peng Dezheng;Zhang Qingfeng;Yang Qiuchu;Li Jiayan;Li Dan;Tang Dongfang;Chen Minzhi;Liang Songping;Liu Yu;Wang Sheng;Liu Zhonghua
3 Variation of Two S3b Residues in K(V)4.1-4.3 Channels Underlies Their Different Modulations by Spider Toxin κ-LhTx-1 期刊论文 Xiao Z;Zhao P;Wu X;Kong X;Wang R;Liang S;Tang C;Liu Z
4 一种具有Nav1.9特异激活作用的蜘蛛多肽毒素及其应用 专利 刘中华;周熙;陈敏芝
5 Electrophysiological and Pharmacological Analyses of Na(v)1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System 期刊论文 Zhou Xi;Xiao Zhen;Xu Yan;Zhang Yunxiao;Tang Dongfang;Wu Xinzhou;Tang Cheng;Chen Minzhi;Shi Xiaoliu;Chen Ping;Liang Songping;Liu Zhonghua
6 Spider venom-derived peptide induces hyperalgesia in Na(v)1.7 knockout mice by activating Na(v)1.9 channels 期刊论文 Zhou Xi;Ma Tingbin;Yang Luyao;Peng Shuijiao;Li Lulu;Wang Zhouquan;Xiao Zhen;Zhang Qingfeng;Wang Li;Huang Yazhou;Chen Minzhi;Liang Songping;Zhang Xianwei;Liu Jing Yu;Liu Zhonghua
7 Advance in Human Epithelial-Derived Organoids Research 期刊论文 Li Fengjiao;Zhang Peng;Wu Saizhi;Yuan Lianwen;Liu Zhonghua
8 Recombinant PaurTx-3, a spider toxin, inhibits sodium channels and decreases membrane excitability in DRG neurons 期刊论文 Chen Minzhi;Peng Shuijiao;Wang Li;Yang Li;Si Yuxin;Zhou Xi;Zhang Yunxiao;Liu Zhonghua
9 Molecular mechanisms of centipede toxin SsTx-4 inhibition of inwardly rectifying potassium channels 期刊论文 Tang D;Xu J;Li Y;Zhao P;Kong X;Hu H;Liang S;Tang C;Liu Z
10 Transcriptomic Analysis of the Spider Venom Gland Reveals Venom Diversity and Species Consanguinity 期刊论文 Hu Zhaotun;Chen Bo;Xiao Zhen;Zhou Xi;Liu Zhonghua
11 Origin and Characterization of Extracellular Vesicles Present in the Spider Venom of Ornithoctonus hainana 期刊论文 Xun Chengfeng;Wang Lu;Yang Hailin;Xiao Zixuan;Deng Min;Xu Rongfang;Zhou Xi;Chen Ping;Liu Zhonghua
12 Two Novel Peptide Toxins from the Spider Cyriopagopus longipes Inhibit Tetrodotoxin-Sensitive Sodium Channels 期刊论文 Qingfeng Zhang;Yuxin Si;Li Yang;Li Wang;Shuijiao Peng;Yiming Chen;Minzhi Chen;Xi Zhou;Zhonghua Liu
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