三种具有镇痛活性的Nav1.8抑制剂的作用机制研究
31570782
2015
C0505.蛋白质、多肽与酶生物化学
刘中华
面上项目
教授
湖南师范大学
62万元
镇痛;作用机制;电压门控钠通道Nav1.8;抑制剂;肽类毒素
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Peptide-rich venom from the spider Heteropoda venatoria potently inhibits insect voltage-gated sodium channels. | 期刊论文 | Huang Yazhou;Wu Xinzhou;Zhang Peng;Duan Zhigui;Zhou Xi;Chen Minzhi;Farooq Athar;Liang Songping;Liu Zhonghua |
| 2 | Engineering Gain-of-Function Analogues of the Spider Venom Peptide HNTX-I, A Potent Blocker of the hNa(V)1.7 Sodium Channel | 期刊论文 | Zhang Yunxiao;Yang Qiuchu;Zhang Qingfeng;Peng Dezheng;Chen Minzhi;Liang Songping;Zhou Xi;Liu Zhonghua |
| 3 | Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System | 期刊论文 | Zhou Xi;Xiao Zhen;Xu Yan;Zhang Yunxiao;Tang Dongfang;Wu Xinzhou;Tang Cheng;Chen Minzhi;Shi Xiaoliu;Chen Ping;Liang Songping;Liu Zhonghua |
| 4 | 一种抗癌活性肽及应用 | 专利 | 刘中华;曾佑林;梁宋平;张鹏;马婧 |
| 5 | 一种蜘蛛细胞毒活性肽在抗肿瘤药物研发中的应用 | 专利 | 刘中华;梁宋平;张鹏 |
| 6 | Purification and Characterization of a Novel Insecticidal Toxin, -sparatoxin-Hv2, from the Venom of the Spider Heteropoda venatoria | 期刊论文 | Xiao Zhen;Zhang Yunxiao;Zeng Jiao;Liang Songping;Tang Cheng;Liu Zhonghua |
| 7 | Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy | 期刊论文 | Tan Huaxin;Huang Yazhou;Zhang Peng;Liang Songping;Liu Zhonghua;Xu Jianghong;Chen Bo;Ye Zhongju;Xiao Lehui;Liu ZH;Xiao LH |
| 8 | Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8 | 期刊论文 | Zhang Fan;Zhang Changxin;Xu Xunxun;Zhang Yunxiao;Gong Xue;Yang Zuqin;Zhang Heng;Tang Dongfang;Liang Songping;Liu Zhonghua |
| 9 | 一种狼蛛抗癌活性肽修饰的纳米金颗粒肿瘤靶向性系统及应用 | 专利 | 刘中华;肖乐辉;梁宋平;谭华欣 |
| 10 | A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line | 期刊论文 | Zhou Xi;Zhang Yunxiao;Tang Dongfang;Liang Songping;Chen Ping;Tang Cheng;Liu Zhonghua |
| 11 | 一种蜘蛛毒素杀虫肽 | 专利 | 刘中华;梁宋平;肖震 |
| 12 | The peptide toxin delta-hexatoxin-MrIX inhibits fast inactivation of Na(V)s in mouse cerebellar granule cells | 期刊论文 | Tang Dongfang;Xiao Zhen;Xu Yan;Zeng Jiao;Peng Dezheng;Liang Songping;Tang Cheng;Liu Zhonghua |
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