KLF4在血管平滑肌细胞染色质重塑和基因表达及表型调制中的作用及机制

90919035
2009
C0603.表观遗传调控
温进坤
重大研究计划
教授
河北医科大学
60万元
KLF4;表型重塑;表观遗传调控因子;组蛋白乙酰化;VSMC
2010-01-01到2012-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Functional interaction of KLF5 with Sp1 upregulates apelin in vascular smooth muscle cells 会议论文 Xin-rui Lv|Xin-rui Lv|Bin Zheng|Bin Zheng|Jin-kun Wen|Jin-kun Wen|
2 TGF-β1 Downregulates AT1 Receptor Expression via PKC- -Mediated Sp1 Dissociation From KLF4 and Smad-Mediated PPAR- Association with KLF4. 期刊论文 Zhang XH|Zhang XH|Zheng B|Zheng B|Gu C|Gu C|Fu JR|Fu JR|Wen JK|Wen JK|
3 HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs. 期刊论文 Zheng B|Han M|Shu YN|Li YJ|Miao SB|Zhang XH|Shi HJ|Zhang T|Wen JK|
4 Retinoic acid receptor alpha mediates all-trans retinoic acid-induced Klf4 gene expression by regulating Klf4 promoter activity in vascular smooth muscle cells. 期刊论文 Shi JH|Shi JH|Zheng B|Zheng B|Chen S|Chen S|Ma GY|Ma GY|Wen JK|Wen JK|
5 RARalpha mediates all-trans retinoic acid-induced KLF4 gene expression through interacting with KLF4, Sp1, and YB1 in vascular smooth muscle cells 会议论文 Jian-hong Shi|Jian-hong Shi|Bin Zheng|Bin Zheng|Si Chen|Si Chen|Guo-yan Ma|Guo-yan Ma|Jin-kun Wen|Jin-kun Wen|
6 Retinoic acid receptor alpha mediates Klf4 gene expression induced by all-trans retinoic acid in vascular smooth muscle cells 会议论文 Jian-hong Shi|Jian-hong Shi|Bin Zheng|Bin Zheng|Guo-yan Ma|Guo-yan Ma|Si Chen|Si Chen|Jin-kun Wen|Jin-kun Wen|
7 KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells. 期刊论文 Shi HJ|Wen JK|Miao SB|Liu Y|Zheng B|
8 Kruppel-like factor 4 promotes differentiation by transforming growth factor-beta receptor-mediated Smad and p38 MAPK signaling in vascular smooth muscle cells. 期刊论文 Li HX|Li HX|Han M|Han M|Bernier M|Bernier M|Zheng B|Zheng B|Sun SG|Sun SG|Su M|Su M|Zhang R|Zhang R|Fu JR|Fu JR|Wen JK|Wen JK|
9 miR-146a and Krüppel-like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferation. 期刊论文 Sun SG|Sun SG|Wen JK|Wen JK|Zheng B|Zheng B| Han M| Han M|Fang XM|Fang XM|Li HX|Li HX|Miao SB|Miao SB|Su M|Su M|Han Y|Han Y|Shi HJ|Shi HJ|
10 Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRbeta-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia. 期刊论文 Dong LH|Wen JK|Miao SB|Jia Z|Hu HJ|Sun RH|Wu Y|Han M|
11 ATRA activates and PDGF-BB represses the SM22 promoter through KLF4 binding to, or dissociating from, its cis-DNA elements. 期刊论文 Yu K, B|Yu K, B|Zheng|Zheng|Han M|Han M| Wen JK| Wen JK|
12 Krüppel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCs. 期刊论文 Zhang R|Zhang R|Han M|Han M|Zheng B|Zheng B|Li YJ|Li YJ|Shu YN|Shu YN|Wen JK|Wen JK|
13 TGF-β1 regulates AT1 receptor expression via PKC-δ- and Smad-mediated signal pathways 会议论文 Xin-hua Zhang|Xin-hua Zhang|Bin Zheng|Bin Zheng|Chun Gu|Chun Gu|Jian-ran Fu|Jian-ran Fu|Jin-kun Wen|Jin-kun Wen|
14 PPARγ通过调节脂质代谢和VSMC增殖参与动脉粥样硬化的发生与发展 会议论文 温进坤|温进坤|张新华|张新华|郑 斌|郑 斌|
15 TGF-β1 downregulates AT1 receptor expression via PKC-δ-mediated Sp1 dissociation from KLF4 and Smad-mediated PPAR-γ association with KLF4 会议论文 Xin-hua Zhang|Xin-hua Zhang|Bin Zheng|Bin Zheng|Chun Gu|Chun Gu|Jian-ran Fu|Jian-ran Fu|Jin-kun Wen|Jin-kun Wen|
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