【30730031】细胞膜受体调节M/KCNQ钾离子通道功能的分子机制的研究国家自然基金项目

细胞膜受体调节M/KCNQ钾离子通道功能的分子机制的研究

项目批准号： 30730031

批准年份： 2007

学科分类： C0503.细胞感应与环境生物物理

项目负责人：张海林

资助类别：重点项目

负责人职称：教授

依托单位：河北医科大学

资助金额： 160万元

关键词：钾离子通道;细胞膜受体;膜磷脂PIP2;Ca2+;调节机制

起止时间： 2008-01-01到2011-12-31

中英文摘要
结题摘要
结题报告
项目成果
项目参与人

查看更多信息请先登录或注册

序号	标题	类型	作者
1	Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions	期刊论文	Wang, Chuan\|Mirshahi, Uyenlinh L.\|Mirshahi, Tooraj\|Liu, Boyi\|Jia, Zhanfeng\|Zhang, Hailin\|
2	Agonist-dependent Potentiation of Vanilloid Receptor TRPV1 Function by Stilbene Derivatives	会议论文	Xuan Zhang\|Xiao-Na Du\|Xing-Juan Chen\|Bo-Yi Liu\| Guo-Hong Zhang\|Zhan-Feng Jia\|Hai-Lin Zhang\|
3	Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats.	期刊论文	Wang C\|Du X\|Zhang H\|
4	Specificity of G beta gamma Signaling Depends on G alpha Subunit Coupling with G-Protein-Sensitive K+ Channels	期刊论文	Du, Xiao-na\|Rusinova, Radda\|Zhang, Xuan\|Chen, Xing-juan\|Logothetis, Diomedes E.\|Geng, Xian\|Li, Fang\|Zhang, Hai-lin\|Liu, Bo-yi\|
5	Ca2+-activated chloride current in A549 cells	会议论文	Zhang HL\|Liu YN\|
6	Genistein inhibits voltage-gated sodium currents in SCG neurons through protein tyrosine kinase-dependent and kinase-independent mechanisms	期刊论文	Jia, Qingzhong\|Zhao, Zhiying\|Liu, Boyi\|Liang, Huiling\|Zhang, Hailin\|Jia, Yueqin\|Jia, Zhanfeng\|
7	受体酪氨酸激酶调节钾离子通道功能的研究进展	期刊论文	刘伯一\|贾占峰\|张海林\|
8	Activation of Ca2+-activated chloride current by membrane depolarization in rat DRG neurons	会议论文	Hai-Lin ZHANG\|Xuan ZHANG\|
9	NGF inhibits M/KCNQ currents and selectively alters neuronal excitability in subsets of sympathetic neurons depending on their M/KCNQ current background	期刊论文	Delmas, Patrick\|Zhang, Hailin\|Rodat-Despoix, Lise\|Bei, Junjie\|Jia, Zhanfeng\|Liu, Boyi\|Jia, Qingzhong\|
10	细胞膜磷脂酰肌醇4,5-二磷酸对TRP通道功能的调节作用	期刊论文	何宏涛\|杜肖娜\|张海林\|
11	The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels	期刊论文	Liu, Boyi\|Linley, John E.\|Gamper, Nikita\|Zhang, Xuan\|Du, Xiaona\|Ooi, Lezanne\|Zhang, Hailin\|
12	Molecular basis for genistein-induced inhibition of Kir2.3 currents	期刊论文	Jia, Zhanfeng\|Liu, Boyi\|Zhang, Guohong\|Zhang, Hailin\|Zhao, Zhiying\|Jia, Qingzhong\|Geng, Xian\|
13	不同日龄大鼠颈上交感神经节神经元电转染方法	期刊论文	赵志英\|刘丽\|张海林\|
14	Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons	期刊论文	Liu, Boyi\|Zhang, Guohong\|Zhang, Hailin\|Zhang, Xuan\|Wang, Chuan\|
15	Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators.	期刊论文	Zhang F\|Zhang D\|Fu Y\|Qi J\|Wu Y\|Mi Y\|Jia Q\|Wang K\|Zhang H\|Xu W\|Du X\|
16	Characteristics and molecular basis of celecoxib modulation on K(v)7 potassium channels	期刊论文	Fu Y\|Zhan Y\|Du XN\|Wan YM\|Gao HX\|Zhang X\|Gao ZB\|Zhang HL\|Li JW\|Qi JL\|An HL\|
17	EGF enhances the migration of cancer cells by up-regulation of TRPM7	会议论文	Hai-Lin ZHANG\|Hai-Xia GAO\|
18	Modulation and underlying signal transduction mechanisms of norepinephrine on the slow component of delayed retifier potassium current	会议论文	Zhang Hailin\|Si Man\|
19	Characteristics and molecular basis of celecoxib modulation on Kv7 potassium channels	会议论文	JW Li\|HX Gao\|YM Wa\|XN Du\|ZB Gao\|HL Zhang\|X Zhang\|HL An\|Y Zhan\|JL Qi\|Y Fu\|
20	The role of cardiac membrane PIP2 in the development of cardiac hypertrophy	会议论文	ZHANG Hailin\|XU Jiaxi\|
21	EGF enhances the migration of cancer cells by up-regulation of TRPM7.	期刊论文	Liu Y\|Du X\|Gao H\|Chen X\|Zhang H\|Guan B\|
22	Membrane depolarization increases membrane PtdIns(4,5)P2 level through PKC beta II and PI4kinase mechanisms	会议论文	Xing-Juan CHEN\|Hai-Lin ZHANG\|
23	脂筏在细胞信号特异性调节钾离子通道功能中的作用	期刊论文	张会然\|张海林\|
24	Phosphatidylinositol 4,5-bisphosphate hydrolysis mediates histamine-induced KCNQ/M current inhibition	期刊论文	Zhang, Hailin\|Liang, Huiling\|Liu, Li\|Liu, Boyi\|
25	Modulation of KCNQ potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58	会议论文	Hai-Lin ZHANG\|Fan ZHANG\|
26	Membrane depolarization increases membrane PtdIns(4,5)P2 levels through mechanisms involving PKC βII and PI4 kinase.	期刊论文	Zhang X\|Gao H\|Chen X\|Zhang H\|Zhang G\|Xu J\|Jia C\|Du X\|
27	蛋白激酶C对内向整流钾离子通道的调节机制	期刊论文	耿仙\|杨冀杰\|陈兴娟\|张璇\|杜肖娜\|张海林\|
28	两种G蛋白偶联受体在调节M电流中所利用G蛋白亚型的鉴定	会议论文	张海林\|梁惠玲\|
29	新型钾通道开放剂(QO-58)在大鼠体内组织分布研究	期刊论文	贾庆忠\|张海林\|刘灿仿\|祈金龙\|
30	Regulation of CCL5 Expression in Smooth Muscle Cells Following Arterial Injury	期刊论文	Fu M\|Ning H\|Zhang H\|Liu H\|Hou R\|Liu J\|Men H\|
31	不同来源的钙对DRG神经元表达的M型钾电流和钙激活氯电流的调节	会议论文	张海林\|张璇 \|
32	Modulation of KCNQ potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58	会议论文	Fan ZHANG\|Hai-Lin ZHANG\|
33	Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives.	期刊论文	Qi J\|Zhang H\|Liu L\|Du X\|Mi Y\|Zhang F\|Chen X\|Jia C\|Zhang X\|
34	缓激肽、离子通道与炎症性疼痛	期刊论文	刘伯一\|张海林\|
35	缩胆囊素引发DRG神经元内向电流并增敏TRPV1电流	会议论文	贾占峰\|张海林\|
36	Depolarization Increases Phosphatidylinositol (PI) 4,5-Bisphosphate Level and KCNQ Currents through PI 4-Kinase Mechanisms	期刊论文	Zhang, Hailin\|Jia, Caixia\|Zhang, Xuan\|Du, Xiaona\|Chen, Xingjuan\|Geng, Xian\|
37	Design, Synthesis and Biological Activity of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Novel Kv7/KCNQ Potassium Channel Activators	会议论文	Xiaona Du\|Qingzhong Jia\|Wen Xu\|KeWei Wang\|Hailin Zhang\|Fan Zhang\|Jinlong Qi\|Yi Mi\|Yan Fu\|
38	水杨酸钠对大鼠颞皮层神经元延迟整流钾通道的抑制作用	期刊论文	刘砚星\|李学佩\|王娜\|陈雪彦\|徐鸥\|张海林\|
39	Role of lipid raft in specificity of cell signaling modulation of M potassium currents	会议论文	ZHANG HL\|ZHANG HR\|
40	特异性cox-2抑制剂celecoxib通过钾离子通道调节作用导致神经元凋亡	会议论文	杜肖娜\|秘尧\|张海林\|
41	TMEM16A:钙激活氯通道研究进展	期刊论文	张海林\|刘雅妮\|

查看更多信息请先登录或注册

再问科研

相关项目

趋势报告

经验分享