crRNA介导的免疫系统的结构与功能研究
91440201
2014
C0503.细胞感应与环境生物物理
王艳丽
重大研究计划
研究员
中国科学院生物物理研究所
300万元
非编码RNA;干扰;晶体结构;RNA-蛋白质复合物;CRISPR/CAS;crRNA
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes | 期刊论文 | Gang Sheng;Tasos Gogakos;Jiuyu Wang;Hongtu Zhao;Artem Serganov;Stefan Juranek;Thomas Tuschl;Dinshaw J. Patel;Yanli Wang |
| 2 | Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities | 期刊论文 | Liang Liu;Xueyan Li;Jiuyu Wang;Min Wang;Peng Chen;Maolu Yin;Jiazhi Li;Gang Sheng;Yanli Wang |
| 3 | Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race | 期刊论文 | Liang Liu;Maolu Yin;Min Wang;Yanli Wang |
| 4 | C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism | 期刊论文 | Liang Liu;Peng Chen;Min Wang;Xueyan Li;Jiuyu Wang;Maolu Yin;Yanli Wang |
| 5 | Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference | 期刊论文 | Lilan You;Jun Ma;Jiuyu Wang;Daria Artamonova;Min Wang;Liang Liu;Hua Xiang;Konstantin Severinov;Xinzheng Zhang;Yanli Wang |
| 6 | Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites | 期刊论文 | Maolu Yin;Jiuyu Wang;Min Wang;Xinmei Li;Mo Zhang;Qiang Wu;Yanli Wang |
| 7 | The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a | 期刊论文 | Liang Liu;Xueyan Li;Jun Ma;Zongqiang Li;Lilan You;Jiuyu Wang;Min Wang;Xinzheng Zhang;Yanli Wang |
| 8 | Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute | 期刊论文 | Daan C. Swarts;Malwina Szczepaniak;Gang Sheng;Stanley D. Chandradoss;Yifan Zhu;Elizabeth M. Timmers;Yong Zhang;Hongtu Zhao;Jizhong Lou;Yanli Wang;Chirlmin Joo;John van der Oost |
| 9 | Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems | 期刊论文 | Jiuyu Wang;Jiazhi Li;Hongtu Zhao;Gang Sheng;Min Wang;Maolu Yin;Yanli Wang |
| 10 | A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses | 期刊论文 | Wang Jiuyu;Ma Jun;Cheng Zhi;Meng Xu;You Lilan;Wang Min;Zhang Xinzheng;Wang Yanli |
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