【30930107】抗真菌药物类药性优化设计平台的创建及先导化合物的优化设计研究国家自然基金项目

抗真菌药物类药性优化设计平台的创建及先导化合物的优化设计研究

项目批准号： 30930107

批准年份： 2009

学科分类： H3401.合成药物化学

项目负责人：张万年

资助类别：重点项目

负责人职称：教授

依托单位：中国人民解放军第二军医大学

资助金额： 184万元

关键词：抗真菌;合成;优化设计;先导化合物;高通量类药性筛选平台

起止时间： 2010-01-01到2013-12-31

中英文摘要
结题摘要
结题报告
项目成果
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序号	标题	类型	作者
1	Evolutionary trace analysis of CYP51 family: implication for site-directed mutagenesis and novel antifungal drug design	期刊论文	Zhang W\|Sheng C\|Chen S\|Ji H\|Dong G\|Che X\|Wang W\|Miao Z\|Yao J\|
2	Structure-based rational design,synthesis and antifungal activity of oxime-containing azole derivatives	期刊论文	Zhang W\|Xu Y\|Sheng C\|Wang W\|Che X\|Cao Y\|Dong G\|Wang S\|Ji H\|
3	Improve Model of Lanosterol 14alpha-Demethylase by Ligand-Supported Homology Modeling:Validation by Virtual Screening and Azole Optimization	期刊论文	Zhang W\|Sheng C\|Wang W\|Che X\|Dong G\|Wang S\|Ji H\|Miao Z\|Yao J\|
4	Total synthesis and structure-activity relationships of new echinocandin-like antifungal cyclolipohexapeptides	期刊论文	Yao, Jianzhong\|Liu, Hongming\|Zhou, Ting\|Chen, Hai\|Miao, Zhenyuan\|Sheng, Chunquan\|Zhang, Wannian\|
5	Structure-based design,synthesis,and antifungal activity of new triazole derivatives	期刊论文	张万年\|Sheng C\|Che X\|Wang W\|Wang S\|Cao Y\|Yao J\|Miao Z\|Zhang W\|
6	Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53-MDM2 Protein-Protein Interaction	期刊论文	Zhang, Wannian\|Miao, Zhenyuan\|Zhu, Lingjian\|Dong, Guoqiang\|Guo, Zizhao\|Wang, Shengzheng\|Zhang, Yongqiang\|Wu, Yuelin\|Yao, Jianzhong\|
7	New Lead Structures in Antifungal Drug Discovery	期刊论文	张万年\|Sheng C\|Zhang W\|
8	Total synthesis and structure-activity relationships of caspofungin-like macrocyclic antifungal lipopeptides	期刊论文	Yao, Jianzhong\|Liu, Hongming\|Zhou, Ting\|Chen, Hai\|Miao, Zhenyuan\|Dong, Guoqiang\|Wang, Shengzheng\|Sheng, Chunquan\|Zhang, Wannian\|
9	New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure-Activity Relationship Analysis and Biological Evaluations.	期刊论文	张万年\|
10	Selection of Evodiamine as a Novel Topoisomerase I Inhibitor by Structure-based Virtual Screening and Hit Opitimization of Evodiamine Derivatives as Antitumor Agents	期刊论文	张万年\|Dong G\|Sheng C\|Wang S\|Miao Z\|Yao J\|Zhang W\|
11	Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping	期刊论文	张万年\|Sheng C\|Che X\|Wang W\|Wang S\|Cao Y\|Yao J\|Miao Z\|Zhang W\|
12	Asymmetric Synthesis,Antifungal Activity and Molecular Modeling of Iodiconazole Isomers	期刊论文	张万年\|Zhang Y\|Wang S\|Miao Z\|Yao J\|Zhang W\|Sheng C\|
13	Novel Conformationally Restricted Triazole Derivatives with Potent Antifungal Activity	期刊论文	Sheng C\|Wang W\|Wang S\|Liu Y\|Dong G\|Cao Y\|Miao Z\|Yao J\|Zhang W\|
14	Fragment Informatics and Computational Fragment-based Drug Design: An Overview and Update.	期刊论文	Sheng C\|张万年\|
15	A New Strategy To Improve the Metabolic Stability of Lactone:Discovery of (20S,21S)-21-Fluoraocamptothecins as Novel,Hydrolytically Stable Topoisomerase I Inhibitors	期刊论文	Zhang W\|Miao Z\|Zhu L\|Dong G\|Zhuang C\|Wu Y\|Wang S\|Guo Z\|Liu Y\|
16	Discovery of highly potent novel antifungal azoles by structure-based rational design	期刊论文	张万年\|Wang W\|Sheng C\|Che X\|Ji H\|Cao Y\|Miao Z\|Yao J\|Zhang W\|
17	Design, Synthesis and Structure-Activity Relationships of New Triazole Derivatives Containing N-Substituted Phenoxypropylamino Side Chains.	期刊论文	张万年\|
18	New Stuategies in the Discovery of Novel Non-Camptothecin Topoisomerase I Inhibitors	期刊论文	张万年\|Sheng C\|Miao Z\|Zhang W\|
19	Design and Synthesis of Novel Triazole Antifungal Derivatives by Structure-based Bioisosterism	期刊论文	张万年\|Sheng C\|Che X\|Wang W\|Wang S\|Cao Y\|Miao Z\|Yao J\|Zhang W\|
20	Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement	期刊论文	Sheng, Chunquan\|Wang, Yan\|Wang, Wenya\|Wang, Shengzheng\|Xu, Bo\|Fan, Guorong\|Dong, Guoqiang\|Liu, Yang\|Yao, Jianzhong\|

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