手性元及不对称途径合成手性药物

29790126
1997
B0106.不对称合成
吴毓林
重大项目
研究员
中国科学院上海有机化学研究所
26万元
手性元.合成.手性药物
1997-06至2001-05
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Application of chiral (salen)Co in catalytic asymmetric reaction and natural product syntheses. 期刊论文 Li. L.-S|Wu. Y.-L|
2 Total synthesis of (10R)- and (10S)-Corossolin: Determination of the stereochemistry at C-10 of the natural corossolin and the differential toxicity toward cancer cells caused by the configuration at 期刊论文 Yu. Q|Yao. Z.-J|Chen. X.-G.|Wu. Y.-L|
3 An Efficient Approach to the Synthesis of Ethyl Esters of 2,6-Anhydro-3-deoxy-D-gluco and D-allo-heptanoates. 期刊论文 Li. L.-S|Wu. Y.|Wu. Y.-L|
4 Formal Synthesis of 3-Deoxy-D-manno-2-Octulosonic Acid (KDO) via A Highly Double-Stereoselective Hetero Diels-Alder Reaction Directed by A New (Salen)CoII Catalyst and Chiral Diene. 期刊论文 Hu. Y.-J|Huang. X.-D|Yao. Z.-J|Wu. Y.-L|
5 Total synthesis of (-)incrustoporin. 期刊论文 Yu. Q|Liu. J.-F|Wu. Y.-L|
6 Enantioselective Synthesis of Ethyl 4,5,7,8,9-penta-O-acetyl-2,6-anhydro-3-deoxy-D-erythro-L-gluco-nononate: a Monodeoxygenated Derivative of '2-Keto-3-deoxy-D-glycero-D-galacto-nononic Acid'. 期刊论文 Shen. X|Wu. Y.-L|Wu. Y.-K|
7 An efficient approach to the 2-nonulosonic acid skeleton though a hetero-Diels-Alder reaction. 期刊论文 Hu. Y.-J|Huang. X.-D|Wu. Y.-L|
8 Radical-mediated construction of cyclopentane with concurrent formation of a well-defined quaternary center. 期刊论文 Zhu. Q|Qiao. L.-X|Wu. Y.-K|Wu. Y.-L|
9 Straightforward Syntheses of Two Pairs of Enantiomeric Butenolides 3-Tetradecyl- and 3-Hexadecyl-5-methyl-2(5H)-furanone. 期刊论文 Zeng. B.-B|Hu. T.-S|Yun.W|Wu. Y|Wu. Y.-L|
10 Synthesis of 3-Deoxy-2-ulosonic Acid KDO and 4-epi-KDN A Highly Efficient Approach of 3-C Homologation by Propargylation and Oxidation. 期刊论文 Li. L.-S.|Wu. Y.-L|
11 Synthesis of a new cerebroside isolated from Typhonium giganteum Engl. 期刊论文 Chen. X.-S|Wu. Y.-L|Chen. D.-H.|
12 The first synthesis of Tonkinecin, an annonaceous acetogenin with A C-5 carbinol center. 期刊论文 Hu. T.-S|Yu. Q|Lin. S|Wu. Y.-L|Wu. Y|
13 Polyether Mimics of Natural Occurring Cytotoxic Annonaceous Acetogenins. 期刊论文 Yao. Z.-J|Wu. H.-P|Wu. Y.-L|
14 Base-catalyzed Epimerization of the Butenolide in annonaceous acetogenin. 期刊论文 Yu. Q|Wu. Y|Wu. Y.-L|Xia. L.-J|Tang. M.-H|
15 An Efficient Method for Synthesis of ?-Keto Acid Esters from Terminal Alkynes. 期刊论文 Li. L.-S|Wu. Y.-L|
16 Synthesis of (2S, 3R, 4E, 8E)-9-Methyl-4,8- Sphingadienine via a Novel SN2' Type Reaction Mediated by A Thioether Carbanion. 期刊论文 Wang. X.-Z|Wu. Y.-L|Jiang. S|Singh. G|
17 Enantioselective syntheses of monotetrahydrofuran annonaceous acetogenins tonkinecin and annonacin starting from carbohydrates. 期刊论文 Hu. T.-S|Yu. Q|Wu. Y.-L|Wu.Y|
18 General and Efficient Syntheses of C18-4,8-Sphingadienines via SN2' Type Homoallylic Coupling Reactions Mediated by Thioether-Stabilized Copper Reagents. 期刊论文 Wang. X.-Z|Wu. Y.-L|Jiang. S.|Singh. G|
19 The First Total Synthesis of Annonacin, the Most Typical Monotetrahydrofuran Annonaceous Acetogenins. 期刊论文 Hu. T.-S|Wu. Y.-L|Wu. Y.-K|
20 Structure Determination and Synthesis of A New Cerebroside Isolated from Traditional Chinese Medicine Typhonium giganteum Engl. 期刊论文 Chen. X.-S|Wu. Y.-L|Chen. D.-H|
21 Total Synthesis of Fully Acetylated N-Acetylneuraminic Acid (Neu5Ac), 2-Deoxy- - Neu5Ac, and 4-epi-2-Deoxy- - Neu5Ac from D-glucose. 期刊论文 Li. L.-S|Wu. Y.-L|Wu. Y.-K|
22 A Concise Approach to the Synthesis of L- and D-Deoxyribose. 期刊论文 Hu. S.-G|Wu. Y|Wu. Y.-L|
23 Studies toward the Total Synthesis of Clavulactone. 期刊论文 Zhu. Q|Qiao. L.-X|Wu. Y|Wu. Y.-L|
24 Syntheses of Two New Mosquito Larvicidal Butenolides . 期刊论文 Jiang. S|Wu. Y.-L|Yao. Z.-J|
25 The first total synthesis of 4-deoxyannomontacin. 期刊论文 Yu. Q|Wu. Y.|Ding. H|Wu. Y.-L|
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