外消旋药物的拆分及无效对映体的转化研究

29790125
1997
B0106.不对称合成
林国强
重大项目
研究员
中国科学院上海有机化学研究所
33万元
手性转化.手性包夹拆分.左旋甲砜霉素
1997-06至2001-05
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Enzymatic Synthesis of (R)-Cyanohydrins by Three (R)-Oxynitrilase Sources in Micro-aqueous Organic Medium 期刊论文 Guoqiang Lin*|Shiqing Han and Zuyi Li|
2 Anti-Prelog microbial Reduction and (R)-Oxynitrilase Catalysed Cyanohydrination 会议论文 Guo-Qiang Lin|
3 Baker’s yeast mediated mono-reduction of 1,3-cyclohexanediones bearing two identical C(2) substituents 期刊论文 Zhi-Liang Wei|Zu-Yi Li|Guo-Qiang Lin|
4 化学拆分的新方法研究 期刊论文 邓金根|迟永祥|朱槿|蒋耀忠|
5 一种新酶源的醇腈裂解酶催化合成光学活性氰醇化合物 期刊论文 林国强、韩世清、李祖义|
6 Biotansformation in Enantioselective Synthesis of Bioactive and Pharmaceutically Interesting Compounds 会议论文 Lin Guo-Qiang|
7 光学纯2-氟-?-甲基-(1,1’-二苯基)-4-乙酸的制备方法 期刊论文 林国强、雷新胜、张爱民、俞晓明、刘汉泉、骆宏丰、夏立钧|
8 First (R)-Oxynitrilase-catalyzed Synthesis of Optically Active Fluorinated Mandelonitriles 期刊论文 Shiqin Han|Peiran Chen|Guoqiang Lin et al|
9 手性亚砜类化合物的包结拆分 期刊论文 邓金根|
10 A novel method of resolution -Chiral inclusion complextion 期刊论文 Feng XM|Zeng DC|Jiang YZ|
11 Resolution of alkyl pyridyl sulfoxides by complexation with a chiral host compound derived from tartaric acid 期刊论文 Zhu J|Qin|He Z|Fu FM|Zhou ZY|Deng JG|Jiang YZ|Chau TY|
12 Resolution of omeprazole by inclusion complexation with a chiral host 期刊论文 Deng JG|Chi|Fu FM|etal|
13 一种从L型取代苯丝氨酸酯制备D-(-)-苏式1-R-取代苯基-2-二氯乙酰氨基-3-氟-1-丙醇的方法 期刊论文 林国强、雷新胜、黄浩、俞晓明、李榕|
14 A Study of asymmetric hydrocyanation of heteroaryl carboxaldehydes catalyzed by (R)-oxynitrilase under micro-aqueous condition 期刊论文 Chen Peiran|Han Shiqing|Lin Guoqiang et al|
15 Biotransformation in Enantioselective Synthesis of Optically Active Compounds 会议论文 林国强|
16 Application of Bioreduction to the Asymmetric Synthesis of Chiral Drugs 期刊论文 魏志亮|李祖义|林国强|
17 Enzymatic Synthesis of (R)-Cyanohydrins by Three (R)-Oxynitrilase Sources in Micro-aqueous Organic Medium 期刊论文 Guoqiang Lin|Shiqing Han|Zuyi Li|
18 Chemoenzymatic Synthesis of Ro 25-8210 and Ro 25-6630 期刊论文 Zhi-Liang Wei|Zu-Yi Li|Guo-Qiang Lin|
19 一种从L型取代苯丝氨酸酯制备D-(-)苏式-2-恶唑啉衍生物的方法 奖励 林国强|张所明|李榕|王志民|
20 氰醇裂解酶催化合成光学活性氰醇化合物 期刊论文 林国强、韩世清、李祖义|
21 Anti-Prelog Microbial Reduction, (R)-Oxynitrilase Catalyzed Cyanohydrination and the Synthesis of Optically Active Compounds 期刊论文 林国强|李祖义|
22 anti-Prelog Microbial Reduction of Aryl a-Halomethyl or a-Hydroxymethyl Ketones with Geotrichum sp. 38 期刊论文 Wei. Z.-L|Li. Z.-Y|Lin. G.-Q|
23 Microbial reduction of sulfer-containing ketones by Geotrichum sp. 期刊论文 Wei Zhi-liang|Li Zu-yi|Lin Guo-qiang|
24 《手性合成——不对称反应及其应用》第一版 专著 林国强|陈耀全|陈新滋|李月明|
25 （R）-乙基-2-吡啶亚砜与（4R,5R）-TADDOL包结晶体（C97）H（9）OS。C（31）H（30） 期刊论文 朱槿|周忠远|付芳敏|邓金根|宓爱巧|蒋耀远|邱太源|
26 Synthesis of (R)-Cyanohydrins by crude (R)-oxynitrilase-catalyzed reactions in micro-aqueous medium 期刊论文 Han. S.-Q|Lin. G.-Q|Li. Z.-Y|
27 《Principles and Applications of Asymmetric Synthesis》 专著 Guo-Qiang Lin|Yue-Ming Li|Albert S. C. Chan|
28 Anti-Prelog Microbial Reduction, (R)-Oxynitrilase Catalyzed Cyanohydrination and Synthesis of Chiral Axial Biaryls 会议论文 林国强|
29 Microbial Transformation of 2-Hydroxy and 2-Acetoxy Ketones with Geotrichum sp. 期刊论文 Wei Zhi-Liang|Lin Guo-qiang|Li Zu-Yi|
30 Studies on crystal structure of inclusion chiral crystal of (R)-ethy1-2pyridy1 sulfoxide with (4R,5R)-TADDOL 期刊论文 Zhu J|Qin Y|He Z|Fu FM|Zhou ZY|Deng JG|Jiang YZ|Chau TY|
31 Studies on crystal structure of inclusion chiral crystal of (R)-ethy1-2pyridy1 sulfoxide with (4R,5R)-TADDOL 期刊论文 Zhu J|Zhou ZY|Fu FM|etal|
32 First Stereoselective Synthesis of the Versatile Chiral Building Block (7aR)-5,6-Dihydro-7a-methyl-1H-indene-2,7(4H,7aH)-dione 期刊论文 Zhi-Liang Wei|Zu-Yi Li|Guo-Qiang Lin|
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