铁调节蛋白IRP2的去泛素化酶鉴定及其在帕金森病黑质铁聚集中的作用研究

31771110
2017
C0901.分子与细胞神经生物学
姜宏
面上项目
教授
青岛大学
63万元
去泛素化;铁调节蛋白2;OTUD3;铁转运蛋白;帕金森病
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The expression change of OTUD3-PTEN signaling axis in glioma cells 期刊论文 YiZhen Liu;XiXun Du;QiQi Zhao;Qian Jiao;Hong Jiang
2 Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism 期刊论文 Zhengyang Yao;Lin Fu;Fengju Jia;Mingxia Bi;Qian Jiao;Xi Chen;Xixun Du;Hong Jiang
3 OTUD3 is involved in UPR of dopaminergic neurons through regulation of PTEN 会议论文 Ling Chen;Tingting Tang;Xuejie Huan;Xiaoting Dang;Shuhua Wang;Qian Jiao;Hong Jiang
4 Expanding the role of proteasome homeostasis in Parkinson's disease: beyond protein breakdown 期刊论文 Mingxia Bi;Xixun Du;Qian Jiao;Xi Chen;Hong Jiang
5 Deubiquitylase OTUD3 prevents Parkinson’s disease through stabilizing iron regulatory protein 2 期刊论文 Fengju Jia;Hongchang Li;Qian Jiao;Chaonan Li;Lin Fu;Chunping Cui;Hong Jiang;Lingqiang Zhang
6 Effects of deubiquitylases on the biological behaviors of neural stem cells 期刊论文 Qiqi Zhao;Yixin Li;Xixun Du;Xi Chen;Qian Jiao;Hong Jiang
7 OTUD3 is involved in endoplasmic reticulum stress of dopaminergic neurons through regulation of PTEN 会议论文 Ling Chen;Tingting Tang;Xuejie Huan;Xue Xiao;Qian Jiao;Hong Jiang
8 Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease 期刊论文 Mingxia Bi;Xixun Du;Xue Xiao;Yingying Dai;Qian Jiao;Xi Chen;Lingqiang Zhang;Hong Jiang
9 细胞因子FAM3C在携带人突变型α-突触核蛋白A53T纯合子小鼠黑质区表达的研究 期刊论文 张培;焦倩;杜希恂;姜宏
10 大鼠帕金森病模型中α-突触核蛋白对干扰素调节因子1的调控及其机制 期刊论文 牟斐斐;陈曦;杜希恂;焦倩;毕明霞;姜宏
11 Deubiquitylase OTUD3 regulates IRP2 stability and iron homeostasis 会议论文 贾凤菊;李洪昌;焦倩;傅琳;焦玲玲;张培;高艺峻;牟斐斐;钟燕敏;崔春萍;张令强;姜宏
12 帕金森病的研究进展 期刊论文 杜希恂;姜宏
13 Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease 期刊论文 Zhang Pei;Chen Ling;Zhao Qiqi;Du Xixun;Bi Mingxia;Li Yong;Jiao Qian;Jiang Hong
14 The Role of Ferroptosis in the Regulation of Survival of Dopaminergic Neurons in Parkinson's Disease 会议论文 张培;焦倩;杜希恂;毕明霞;姜宏
15 帕金森病病因与发病机制研究现状及其诊治意义 期刊论文 焦倩;姜宏
16 Glut9-mediated urate uptake is responsible for its protective effects on dopaminergic neurons in Parkinson’s disease models 期刊论文 Mingxia Bi;Qian Jiao;Xixun Du;Hong Jiang
17 High dietary iron supplement induces the nigrostriatal dopaminergic neurons lesion in transgenic mice expressing mutant A53T human alpha-synuclein 期刊论文 Fengju Jia;Ning Song;Weiwei Wang;Xixun Du;Yajing Chi;Hong Jiang
18 Oxidative stress regulated iron regulatory protein IRP2 through FBXL5-mediated ubiquitination-proteasome way in SH-SY5Y cells 期刊论文 Qian Jiao;XiXun Du;Jie Wei;Yong Li;Hong Jiang
19 The S-nitrosylation of parkin attenuated the ubiquitination of divalent metal transporter 1 in MPP+-treated SH-SY5Y cells 期刊论文 Yanmin Zhong;Xin Li;Xixun Du;Mingxia Bi;Fengtong Ma;Junxia Xie;Hong Jiang
20 去泛素化酶OTUD3调控胆固醇酯化酶SOAT1蛋白稳定性的机制 期刊论文 盖文彬;毕明霞;姜宏
21 Investigation of behavioral dysfunctions induced by monoamine depletions in a mouse model of Parkinson’s disease 期刊论文 Yong Li;Qian Jiao;Xixun Du;Mingxia Bi;Shuaishuai Han;Lingling Jiao;Hong Jiang
22 α‑Synuclein regulates iron homeostasis via preventing Parkin-mediated DMT1 ubiquitylation in Parkinson’s disease models 期刊论文 Mingxia Bi;Xixun Du;Qian Jiao;Zhiguo Liu;Hong Jiang
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