【31271150】人参皂苷Rg1通过抑制炎症反应保护多巴胺能神经元的分子机制研究国家自然基金项目

人参皂苷Rg1通过抑制炎症反应保护多巴胺能神经元的分子机制研究

项目批准号： 31271150

批准年份： 2012

学科分类： C0901.分子与细胞神经生物学

项目负责人：陈文芳

资助类别：面上项目

负责人职称：教授

依托单位：青岛大学

资助金额： 80万元

关键词：类固醇激素受体;人参皂苷Rg1;小胶质细胞;胰岛素样生长因子I受体;帕金森病

起止时间： 2013-01-01到2016-12-31

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序号	标题	类型	作者
1	Glucocorticoid receptor is involved in the neuroprotective effect of ginsenoside Rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra.	期刊论文	Chen L\|Gao XQ\|Xie JX\|Chen WF\|
2	Protective effects of Ginsenoside Rg1 on LPS-induced Astrocyte Activation in cultured rat primary astrocytes	会议论文	Zhang XJ\|Zhao X\|Chen WF\|
3	Effects of ginsenoside Rg1 and insulin-like growth factor-I on dopaminergic neurons in Parkinson's disease mice	会议论文	Yan Z\|Xue DD\|Chen XH\|Chen WF\|
4	淫羊藿总黄酮对帕金森病模型小鼠多巴胺能神经元保护作用	期刊论文	薛丹丹\|杨晶\|杨博文\|陈文芳\|
5	PI3K/Akt signaling pathway is involved in the neuroprotective effects of icariin on dopaminergic neurons in the mice model of Parkinson's disease	会议论文	Sun XC\|Gao XQ\|Wu L\|Chen WF\|
6	Rg1和GR阻断剂对脂多糖诱导的BV2小胶质细胞 iNOS及COX-2蛋白表达的影响	期刊论文	王宇鑫\|闫伟宁\|马灵志\|陈文芳\|
7	Involvement of IGF-1 receptor signaling pathway in the neuroprotectiveeffects of Icaritin against MPP+-induced toxicity in MES23.5 cells	期刊论文	Chen XH\|Zhao X\|Zhang XJ\|Chen WF\|
8	雌激素膜受体激动剂G1对脂多糖诱导的小胶质细胞iNOS表达的影响	期刊论文	姜明春\|陈筱涵\|王雅迪\|陈文芳\|
9	The involvement of G protein-coupled estrogen receptor in the neuroprotective effect of ginsenoside Rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra	会议论文	陈文芳\|
10	Inhitory effect of ginsenoside RG1 on inflammation-induced dopaminergic neuron-degeneration by IGF-IR and GR	会议论文	孙宪昌\|陈文芳\|
11	Estrogenic effecs of ginsenoside Rg1 in endometrial Ishikawa cells and neuroblastoma SK-N-SH cells were not observed in preosteoblast MC3T3-E1 cells	会议论文	Chen WF\|Gao QG\|Wong MS\|
12	Neuroprotective properties of icariin inMPTP-induced mouse model of Parkinson’s disease: involvement of PI3K/Akt andMEK/ERK signaling pathways	期刊论文	Xu AL\|Chen XH\|Teng JJ\|Wong MS\|
13	GPER agonist G1 attenuates LPS-induced inflammatory responses in murine BV-2microglial cells	会议论文	陈文芳\|
14	Icariin protects against MPP+-inducedneurotoxicity in MES23.5 cells	期刊论文	Xu Ai-Li\|Jiang MC\|Chen XH\|Chen WF\|
15	第四届全国大学生基础医学创新论坛暨实验设计大赛	奖励	王雅迪\|张公杰\|范晓宇\|陈文芳\|
16	铁与人类健康	专著	王福娣\|谢俊霞\|陈文芳\|
17	人参皂苷Rg1抑制炎症反应保护黑质多巴胺能神经元的实验研究	奖励	孙宪昌\|陈文芳\|
18	人参皂苷Rg1和IGF-I对帕金森病小鼠DA能神经元作用	期刊论文	吴林\|薛丹丹\|高先琦\|陈文芳\|
19	Involvement of IGF-I receptor and estrogen receptor pathways in the protective effects of ginsenoside Rg1 aganist Abeta25-35-induced toxicity in PC12 cells.	期刊论文	Chen L\|Wu L\|Gao QG\|Wong MS\|
20	The protective effects of icaritin against MPP+-induced toxicity in MES 23.5 cell	会议论文	高先琦\|刘航\|徐潇\|陈文芳\|
21	Icariin attenuates microglial activation and learning and memory deficits via suppressing neuroinflammation in LPS-induced mice	会议论文	Zhao X\|Zhang XJ\|Chen WF\|
22	Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via Gprotein-coupled estrogen receptor in murine BV2 microglial cells	会议论文	Chen WF\|Gao XiQ\|
23	Involvement ofglucocorticoid receptor in the anti-inflammatory effects of ginsenoside Rg1 inBV2 microglial cells	会议论文	Ren Xiao-Fan\|Du Zhong-Rui\|Chen Wen-Fang\|
24	Inhibition of neuroinflammation in LPS-activated microglia by genistein	会议论文	Du Zhong-Rui\|Ren Xiao-Fan\|Chen Wen-Fang\|
25	神经生物学-从神经元到脑	专著	翁史钧\|陈蕾\|蒋正尧\|陈文芳\|

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