【30930036】帕金森病黑质内铁选择性聚集并特异性损伤多巴胺能神经元的机制及防治研究国家自然基金项目

帕金森病黑质内铁选择性聚集并特异性损伤多巴胺能神经元的机制及防治研究

项目批准号： 30930036

批准年份： 2009

学科分类： H0912.神经退行性变及相关疾病

项目负责人：谢俊霞

资助类别：重点项目

负责人职称：教授

依托单位：青岛大学

资助金额： 164万元

关键词：铁螯合剂;铁;ATP敏感性钾通道;铁调节蛋白;帕金森病

起止时间： 2010-01-01到2013-12-31

中英文摘要
结题摘要
结题报告
项目成果
项目参与人

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序号	标题	类型	作者
1	Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson’s disease.	会议论文	Yu X\|Du T\|Song N\|He Q\|Shen Y\|Xie J\|
2	Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in Parkinson's disease.	期刊论文	Shi ZH\|Nie G\|Duan XL\|Rouault T\|Wu WS\|Ning B\|Zhang N\|Chang YZ\|Zhao BL\|
3	Iron aggravates microglia activation and neuronal iron accumulation in vitro.	会议论文	Wang J\|Song N\|Jiang H\|Wang J\|Xie J\|
4	Curcumin protects nigral dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model of Parkinson's disease.	会议论文	Du X\|Xu H\|Jiang H\|Song N\|Wang J\|Xie J\|
5	Iron Physiology and Pathophysiology in Humans	专著	王福俤\|谢俊霞\|
6	Akt/nrf2 activated upregulation of heme oxygenase-1 involves in the role of rg1 against ferrous iron-induced neurotoxicity in sk-n-sh cells.	会议论文	Du X\|Xu H\|Song N\|Jiang H\|Xie J\|
7	Ndfip1 attenuats 6-OHDA-inducedcellular iron accumulation via degradation of DMT1 in dopaminergic cells.	会议论文	Jia W\|Xu H\|Jiang H\|Xie J\|
8	Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels.	会议论文	Shi L\|Bian X\|Qu Z\|Ma Z\|Zhou Y\|Wang K\|Jiang H\|Xie J\|
9	Rg1 Protects Iron-Induced Neurotoxicity Through Antioxidant and Iron Regulatory Proteins in 6-OHDA-Treated MES23.5 Cells.	期刊论文	Xu H\|Jiang H\|Xie J\|
10	Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels	期刊论文	Shi L\|Bian X\|Qu Z\|Ma Z\|Zhou Y\|Wang K\|Jiang H\|Xie J\|
11	6-hydroxydopamine promotes iron traffic in primary cultured astrocytes	期刊论文	Zhang HY\|Wang ND\|Song N\|Xu H\|Shi L\|Jiang H\|Xie J\|
12	Rg1 protects the MPP(+)-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake.	期刊论文	Xu H\|Jiang H\|Wang J\|Xie J\|
13	β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease	期刊论文	Wan L\|Nie G\|Zhang J\|Luo Y\|Zhang P\|Zhang Z\|Zhao B\|
14	Neurorescue effect of rosmarinic acid on 6-hydroxydopamine-lesioned nigral dopamine neurons in rat model of Parkinson's disease.	会议论文	Wang J\|Xu H\|Jiang H\|Du X\|Xie J\|
15	Ndfip1 mediated DMT1 degradation reduces iron accumulation in 6-OHDA treated MES23.5 cells.	会议论文	Jia W\|Xu H\|Jiang H\|Xie J\|
16	L-Type Cav1.2 Calcium Channel is Involved in 6-Hydroxydopamine-Induced Neurotoxicity in Rats	期刊论文	Wang R\|Ma Z\|Wang J\|Xie J\|
17	Effect of iron liposomes on anemia of inflammation.	期刊论文	Yuan L\|Geng L\|Ge L\|Yu P\|Duan X\|Chen J\|Chang Y\|
18	Akt/Nrf2 Activated Upregulation of Heme Oxygenase-1 Involves in the Role of Rg1 Against Ferrous Iron-Induced Neurotoxicity in SK-N-SH Cells	期刊论文	Du, Xixun\|Xu, Huamin\|Jiang, Hong\|Xie, Junxia\|
19	Neurorescue Effect of Rosmarinic Acid on 6-Hydroxydopamine-Lesioned Nigral Dopamine Neurons in Rat Model of Parkinson's Disease	期刊论文	Wang J\|Xu H\|Jiang H\|Du X\|Sun P\|Xie J\|
20	脑内高铁致帕金森病的分子机制及防治策略	奖励	谢俊霞\|姜宏\|宋宁\|徐华敏\|王俊\|
21	Akt/Nrf2 activated upregulation of heme oxygenase-1 involves in the role of Rg1 against ferrous iron-induced neurotoxicity in SK-N-SH cells.	会议论文	Du X\|Xu H\|Song N\|Jiang H\|Xie J\|
22	Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent.	期刊论文	Jiang H\|Song N\|Xu H\|Zhang S\|Wang J\|Xie J\|
23	多巴胺能神经元损伤导致帕金森病的基础和应用研究	奖励	谢俊霞\|姜宏\|王俊\|马泽刚\|宋宁\|徐华敏\|刘彬\|
24	Curcumin protects nigral dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model of Parkinson's disease	期刊论文	Du X\|Xu H\|Jiang H\|Song N\|Wang J\|Xie J\|
25	Neuroprotective effect of porphyra polysaccharide on 6-OHDA-induced cytotoxicity in MES23.5 dopaminergic cells.	会议论文	Wang W\|Song N\|Xie J\|Jiang H\|
26	Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease	期刊论文	Song, N\|Wang, J\|Jiang, H\|Xie, J\|
27	脑内多巴胺	专著	金国章\|镇学初\|谢俊霞\|
28	Ferroportin1 and hephaestin overexpression attenuate iron-induced oxidative stress in MES23.5 dopaminergic cells.	期刊论文	Song N\|Wang J\|Jiang H\|Xie J\|
29	Nifedipine prevents iron accumulation and reverses iron-overload-induced dopamine neuron degeneration in the substantia nigra of rats.	期刊论文	Ma Z\|Zhou Y\|Xie J\|
30	HO-1 participates differentially in astroglia and neurons vulnerability.	会议论文	Yu X\|Song N\|Jiang H\|Xie J\|
31	铁代谢与相关疾病	专著	钱忠明\|谢俊霞\|
32	Quinic acid could be a potential rejuvenating natural compound by improving survival of caenorhabditis elegans under deleterious conditions.	期刊论文	Zhang L\|Zhang J\|Zhao B\|Zhao-Wilson X\|
33	6-Hydroxydopamine upregulates iron regulatory protein 1 by activating certain protein kinase C isoforms in the dopaminergic MES23.5 cell line.	期刊论文	Wang W\|Song N\|Zhang H\|Xie J\|Wang J\|
34	6-Hydroxydopamine Promotes Iron Traffic in Primary Cultured Astrocytes.	会议论文	Zhang H\|Song N\|Xu H\|Shi L\|Jiang H\|Xie J\|
35	脑内高铁损伤多巴胺能神经元致帕金森病的机制及其干预研究	奖励	谢俊霞\|姜宏\|王俊\|宋宁\|徐华敏\|
36	Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons	期刊论文	Wang J\|Song N\|Jiang H\|Wang J\|Xie J\|
37	Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells	期刊论文	Zhang K\|Ma Z\|Wang J\|Xie A\|Xie J\|
38	High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats.	会议论文	Sun C\|Song N\|Xie A\|Xie J\|Jiang H\|
39	Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channel via GHS-R1a-PLC-PKC pathway.	会议论文	Shi L\|Bian X\|Qu Z\|Ma Z\|Zhou Y\|Wang K\|Jiang H\|Xie J\|
40	Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress	期刊论文	Yan J\|Zhao Y\|Suo S\|Liu Y\|Zhao B\|
41	Ghrelin prevents 1-methyl-4-phenylpyridinium ion-induced cytotoxicity through anti-oxidation and NF-kappaB modulation in MES23.5 cells.	期刊论文	Liu L\|Xu H\|Jiang H\|Wang J\|Song N\|Xie J\|
42	6-Hydroxydopamine upregulates iron regulatory protein 1 by activating certain protein kinase C isoforms in the dopaminergic MES23.5 cell line	会议论文	Wang W\|Song N\|Zhang H\|Xie J\|
43	Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson’s disease	期刊论文	Yu X\|Du T\|Song N\|He Q\|Shen Y\|Jiang H\|Xie J\|
44	Protective effect of theaflavins on neuron against 6-hydroxydopamine-induced apoptosis in SH-SY5Y cells.	期刊论文	Luo Z\|Zhao Y\|Wang Y\|Yang X\|Zhao B\|
45	Significant longevity-extending effects of a tetrapeptide from maize on C elegans under stress.	期刊论文	Wu H\|Zhao Y\|Guo Y\|Xua L\|Zhao B\|
46	二价阳离子转运体1在帕金森病黑质铁聚积中的作用	奖励	姜宏\|徐华敏\|谢俊霞\|宋宁\|王俊\|
47	铁代谢失衡疾病的分子生物学原理	专著	常彦忠\|姜宏\|
48	High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats	期刊论文	Sun C\|Song N\|Xie A\|Xie J\|Jiang H\|
49	Role of alpha-synuclein aggregation in iron-induced neurotoxicity	会议论文	Jiang H\|He Q\|Li W\|Song N\|Xie J\|
50	Mitochondrial ferritin attenuates β-amyloid-induced neurotoxicity: Reduction in oxidative damage through the Erk/P38 MAPK pathways.	期刊论文	Chang Y\|Zhao Y\|Shi Z\|Chang S\|Nie G\|Duan X\|Zhao S\|Wu Q\|Yang Z\|

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