基于自噬介导YAP1/STAT3途径探讨PD-L1在肝癌免疫抑制微环境失调进程中的作用及双氢青蒿素的调控效应

81873112
2018
H3302.中西医结合临床基础
石新丽
面上项目
教授
河北中医学院
56万元
Yes关联蛋白1;消化系统肿瘤;程序性死亡配体1;青蒿素;肿瘤免疫抑制
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Dihydroartemisinin broke the tumor immunosuppressive microenvironment by inhibiting YAP1 expression to enhance anti-PD-1 efficacy 期刊论文 Qing Peng;Shenghao Li;Xinli Shi;Yinglin Guo;Liyuan Hao;Zhiqin Zhang;Jingmin Ji;Yanmeng Zhao;Caige Li;Yu Xue;Yiwei Liu
2 YAP1 suppression inhibits autophagy and improves the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma 期刊论文 Yuting Gao;Qing Peng;Shenghao Li;Kangning Zheng;Yi Gong;Yu Xue;Yiwei Liu;Junlan Lu;Yuman Zhang;Xinli Shi
3 Dihydroartemisinin promoted FXR expression independent of YAP1 in hepatocellular carcinoma 期刊论文 Yinglin Guo;Qing Peng;Liyuan Hao;Jingmin Ji;Zhiqin Zhang;Yu Xue;Yiwei Liu;Yuting Gao;Caige Li;Xinli Shi
4 Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma 期刊论文 Liyuan Hao;Yinglin Guo;Qing Peng;Zhiqin Zhang;Jingmin Ji;Yiwei Liu;Yu Xue;Caige Li;Kangning Zheng;Xinli Shi
5 原发性肝癌中PD-L1表达的调控机制 期刊论文 李圣豪;石新丽
6 Anti‑malarial drug dihydroartemisinin downregulates the expression levels of CDK1 and CCNB1 in liver cancer 期刊论文 Liyuan Hao;Shenghao Li;Qing Peng;Yinglin Guo;Jingmin Ji;Zhiqin Zhang;Yu Xue;Yiwei Liu;Xinli Shi
7 Cisplatin promotes the expression level of PD-L1 in the microenvironment of hepatocellular carcinoma through YAP1 期刊论文 Shenghao Li;Jingmin Ji;Zhiqin Zhang;Qing Peng;Liyuan Hao;Yinglin Guo;Wenhan Zhou;Qingzhuo Cui;Xinli Shi
8 Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy 期刊论文 Zhiqin Zhang;Xinli Shi;Jingmin Ji;Yinglin Guo;Qing Peng;Liyuan Hao;Yu Xue;Yiwei Liu;Caige Li;Junlan Lu;Kun Yu
9 基于转录组学分析双氢青蒿素干预肝癌细胞 HepG2215后的基因表达差异 期刊论文 高玉亭;郝立园;彭晴;国英琳;石新丽
10 Integrated analysis of transcriptomics and metabolomics in human hepatocellular carcinoma HepG2215 cells after YAP1 knockdown 期刊论文 Yuting Gao;Yi Gong;Yiwei Liu;Yu Xue;Kangning Zheng;Yinglin Guo;Liyuan Hao;Qing Peng;Xinli Shi
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