5-异喹啉磺胺类化合物Fasudil对Kv7钾通道的选择性作用机制及其生理学意义
31401003
2014
C1105.整合生理学与整合生物学
张璇
青年科学基金项目
副教授
河北中医学院
24万元
Kv7钾通道;舒血管;膜片钳;法舒地尔;亚型选择性开放剂
2015-01-01到2017-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects | 期刊论文 | Zhang Xuan;Li Honglin;Zhang Huiran;Liu Yani;Huo Lifang;Jia Zhanfeng;Xue Yucong;Sun Xiaorun;Zhang Wei |
| 2 | 天然黄酮类化合物抗肿瘤作用靶点研究进展 | 期刊论文 | 孙晓润;陈苹苹;林悦;张建平;王翀奎;张璇 |
| 3 | Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. | 期刊论文 | Xi Chu;Yusong Guo;Bingyuan Xu;Wenya Li;Yue Lin;Xiaorun Sun;Chunhua Ding;Xuan Zhang |
| 4 | Tannic acid modulates excitability of sensory neurons and nociceptive behavior and the ionic mechanism. | 期刊论文 | Xuan Zhang;Huiran Zhang;Najing Zhou;Jiaxi Xu;Man Si;Zhanfeng Jia;Xiaona Du;Hailin Zhang |
| 5 | Selective activation of vascular Kv 7.4/Kv 7.5 K+ channels by fasudil contributes to its vasorelaxant effect. | 期刊论文 | Zhang Xuan;An Hailong;Li Junwei;Zhang Yuanyuan;Liu Yang;Jia Zhanfeng;Zhang Wei;Chu Li;Zhang Hailin |
| 6 | Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+) channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries. | 期刊论文 | Zhang Yuanyuan;Chu Xi;Liu Ling;Zhang Nan;Guo Hui;Yang Fan;Liu Zhenyi;Dong Yongsheng;Bao Yifan;Zhang Xuan;Zhang Jianping |
| 7 | Characterization and structure-activity relationship of natural flavonoids as hERG K+ channel modulators | 期刊论文 | Xiaorun Sun;Bingyuan Xu;Yucong Xue;Honglin Li;Huiran Zhang;Yuanyuan Zhang;Liying Kang;Xiaolu Zhang;Jianping Zhang;Zhanfang Jia;Xuan Zhang |
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