全反式维甲酸（ATRA）调控肝癌干细胞抑制肝癌合并门静脉癌栓化疗耐药机制、敏感标志物筛选及其临床应用研究
81730097
2017
H35.药理学
程树群
重点项目
教授
中国人民解放军第二军医大学
300万元
肝细胞肝癌;全反式维甲酸;门静脉癌栓;耐药机制;敏感标志物
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Actual long-term survival in hepatocellular carcinoma patients with microvascular invasion: a multicenter study from China | 期刊论文 | Zhen-Hua Chen;Xiu-Ping Zhang;Jin-Kai Feng;Le-Qun Li;Fan Zhang;Yi-Ren Hu;Cheng-Qian Zhong;Jie Shi;Wei-Xing Guo;Meng-Chao Wu;Wan Yee Lau;Shu-Qun Cheng |
| 2 | Typing of biliary tumor thrombus influences the prognoses of patients with hepatocellular carcinoma | 期刊论文 | Juxian Sun;Jiayi Wu;Chang Liu;Jie Shi;Yonggang Wei;Jianyin Zhou;Zhibo Zhang;Wan Yee Lau;Maolin Yan;Shuqun Cheng |
| 3 | Scinderin suppresses cell proliferation and predicts the poor prognosis of hepatocellular carcinoma | 期刊论文 | Bin Zhou;Tian‑Wei Chen;Ya‑Bo Jiang;Xu‑Biao Wei;Chong‑De Lu;Jingjing Li;Dong Xie;Shu-Qun Cheng |
| 4 | Image-matching digital macro-slide—a novel pathological examination method for microvascular invasion detection in hepatocellular carcinoma | 期刊论文 | Hong-Ming Yu;Kang Wang;Jin-Kai Feng;Lei Lu;Yu-Chen Qin;Yu-Qiang Cheng;Wei-Xing Guo;Jie Shi;Wen-Ming Cong;Wan Yee Lau;Hui Dong;Shu-Qun Cheng |
| 5 | Concurrent bile duct resection versus concomitant thrombectomy for hepatocellular carcinoma associated with bile duct tumor thrombus: a propensity score matching analysis | 期刊论文 | Feng Jin-Kai;Chen Zhen-Hua;Sun Ju-Xian;Wu Jia-Yi;Guo Wei-Xing;Shi Jie;Wei Yong-Gang;Zhou Jian-Yin;Zhang Zhi-Bo;Yan Mao-Lin;Cheng Shu-Qun |
| 6 | Postoperative adjuvant sorafenib improves survival outcomes in hepatocellular carcinoma patients with microvascular invasion after R0 liver resection: a propensity score matching analysis | 期刊论文 | Xiu-Ping Zhang;Zong-Tao Chai;Yuzhen Gao;Zhen-Hua Chen;Kang Wang;Jie Shi;Wei-Xing Guo;Teng-Fei Zhou;Jin Ding;Wen-Ming Cong;Dong Xie;Wan Y. Lau;Shu-Qun Cheng |
| 7 | Thrombocytopenia: a prognostic factor for hepatocellular carcinoma patients with portal vein tumor thrombus after hepatectomy | 期刊论文 | Yu‐Qiang Cheng;Kang Wang;Xiu‐Ping Zhang;Xu‐Biao Wei;Ya‐Bo Jiang;Yi‐Ren Hu;Fei‐Fei Mao;Wei‐Xing Guo;Jie Shi;Shu‐Qun Cheng |
| 8 | Compartmentalized evolution of hepatitis B virus contributes differently to the prognosis of hepatocellular carcinoma | 期刊论文 | Jianhua Yin;Xi Chen;Nan Li;Xuewen Han;Wenbin Liu;Rui Pu;Ting Wu;Yibo Ding;Hongwei Zhang;Jun Zhao;Xue Han;Hongyang Wang;Shuqun Cheng;Guangwen Cao |
| 9 | An Eastern Hepatobiliary Surgery Hospital/Portal Vein Tumor Thrombus Scoring System as an Aid to Decision Making on Hepatectomy for Hepatocellular Carcinoma Patients With Portal Vein Tumor Thrombus: A Multicenter Study | 期刊论文 | Xiu‐Ping Zhang;Yu‐Zhen Gao;Zhen‐Hua Chen;Min‐Shan Chen;Le‐Qun Li;Tian‐Fu Wen;Li Xu;Kang Wang;Zong‐Tao Chai;Wei‐Xing Guo;Jie Shi;Dong Xie;Meng‐Chao Wu;Wan Yee Lau;Shu‐Qun Cheng |
| 10 | An Eastern Hepatobiliary Surgery Hospital Microvascular Invasion Scoring System in Predicting Prognosis of Patients with Hepatocellular Carcinoma and Microvascular Invasion After R0 Liver Resection: A Large-Scale, Multicenter Study | 期刊论文 | Xiu-Ping Zhang;Kang Wang;Xu-Biao Wei;Le-Qun Li;Hui-Chuan Sun;Tian-Fu Wen;Zong-Tao Chai;Zhen-Hua Chen;Jie Shi;Wei-Xing Guo;Dong Xie;Wen-Ming Cong;Meng-Chao Wu;Wan Yee Lau;Shu-Qun Cheng |
| 11 | In-hospital Mortality after Surgical Resection in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus | 期刊论文 | Xiu-Ping Zhang;Yu-Zhen Gao;Zhen-Hua Chen;Kang Wang;Yu-Qiang Cheng;Wei-Xing Guo;Jie Shi;Cheng-Qian Zhong;Fan Zhang;Shu-Qun Cheng |
| 12 | Prognostic Value of Microvascular Invasion in Eight Existing Staging Systems for Hepatocellular Carcinoma: A Bi-Centeric Retrospective Cohort Study | 期刊论文 | Xiang Yan-Jun;Wang Kang;Zheng Yi-Tao;Yu Hong-Ming;Cheng Yu-Qiang;Wang Wei-Jun;Shan Yun-Feng;Cheng Shu-Qun |
| 13 | Radiotherapy prior to or after transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma with portal vein tumor thrombus: a randomized controlled trial | 期刊论文 | Lei Guo;Xubiao Wei;Shuang Feng;Jian Zhai;Weixing Guo;Jie Shi;Wan Yee Lau;Yan Meng;Shuqun Cheng |
| 14 | Liver resection versus transcatheter arterial chemoembolization for the treatment of patients with hepatocellular carcinoma and hepatic vein or inferior vena cava tumor thrombus: a propensity score matching analysis | 期刊论文 | Zhen‐Hua Chen;Xiu‐Ping Zhang;Kang Wang;Ju‐Xian Sun;Zong‐Tao Chai;Yang Yang;Wei‐Xing Guo;Jie Shi;Wan Yee Lau;Shu‐Qun Cheng |
| 15 | A serological scoring system to predict lymph node metastasis in patients with hepatocellular carcinoma | 期刊论文 | Xiu-Ping Zhang;Yu-Zhen Gao;Ya-Bo Jiang;Kang Wang;Zhen-Hua Chen;Wei-Xing Guo;Jie Shi;Yao-Jun Zhang;Min-Shan Chen;Wan Y.Lau;Shu-Qun Cheng |
| 16 | Nomogram for prediction of the international study Group of Liver Surgery (ISGLS) grade B/C Posthepatectomy liver failure in HBV-related hepatocellular carcinoma patients: an external validation and prospective application study | 期刊论文 | Jia-zhou Ye;Rong-yun Mai;Wei-xing Guo;Yan-yan Wang;Liang Ma;Bang-de Xiang;Shu-qun Cheng;Le-qun Li |
| 17 | Association of Preoperative Coagulability With Incidence and Extent of Portal Vein Tumor Thrombus and Survival Outcomes in Hepatocellular Carcinoma After Hepatectomy: A Large-Scale, Multicenter Study | 期刊论文 | Zhang Xiu-Ping;Zhou Teng-Fei;Feng Jin-Kai;Sun Zi-Yang;Zhen Zuo-Jun;Zhou Dong;Zhang Fan;Hu Yi-Ren;Zhong Cheng-Qian;Chen Zhen-Hua;Chai Zong-Tao;Wang Kang;Shi Jie;Guo Wei-Xing;Wu Meng-Chao;Lau Wan Yee;Cheng Shu-Qun |
| 18 | Thrombus-First Surgery for Hepatocellular Carcinoma with Bile Duct Tumor Thrombus | 期刊论文 | Ju-Xian Sun;Jia-Yi Wu;Jie Shi;Chang Liu;Yong-Gang Wei;Jianyin Zhou;Zhi-Bo Zhang;Mao-Lin Yan;Shu-Qun Cheng |
| 19 | Actual long-term survival in HCC patients with portal vein tumor thrombus after liver resection: a nationwide study | 期刊论文 | Zhen-Hua Chen;Xiu-Ping Zhang;Yu-Gang Lu;Le-Qun Li;Min-Shan Chen;Tian-Fu Wen;Wei-Dong Jia;Dong Zhou;Jing Li;Ding-Hua Yang;Zuo-Jun Zhen;Yi-Jun Xia;Rui-Fang Fan;Yang-Qing Huang;Yu Zhang;Xiao-Jing Wu;Yi-Ren Hu;Yu-Fu Tang;Jian-Hua Lin;Fan Zhang;Cheng-Qian Zhong;Wei-Xing Guo;Jie Shi;Joseph Lau;Shu-Qun Cheng |
| 20 | The impact of portal vein tumor thrombus on long-term survival after liver resection for primary hepatic malignancy | 期刊论文 | Zhang Fan;Lu Chong-De;Zhang Xiu-Ping;Zhong Cheng-Qian;Hu Yi-Ren;Wei Xu-Biao;Zhou Bin;Wang Kang;Chai Zong-Tao;Wu Meng-Chao;Lau Wan Yee;Cheng Shu-Qun |
| 21 | Patterns, Treatments, and Prognosis of Tumor Recurrence After Resection for Hepatocellular Carcinoma with Microvascular Invasion: A Multicenter Study from China | 期刊论文 | Zhen-Hua Chen;Xiu-Ping Zhang;Jin-Kai Feng;Le-Qun Li;Fan Zhang;Yi-Ren Hu;Cheng-Qian Zhong;Kang Wang;Zong-Tao Chai;Xu-Biao Wei;Jie Shi;Wei-Xing Guo;Meng-Chao Wu;Wan Yee Lau;Shu-Qun Cheng |
| 22 | Transcatheter arterial chemoembolization plus atezolizumab and bevacizumab for unresectable hepatocellular carcinoma: a single-arm, phase 2 trial | 期刊论文 | Kang Wang;Hong-Ming Yu;Yan-Jun Xiang;Yu-Qiang Cheng;Qian-Zhi Ni;Wei-Xing Guo;Jie Shi;Shuang Feng;Jian Zhai;Shu-Qun Cheng |
| 23 | A new classification for hepatocellular carcinoma with hepatic vein tumor thrombus | 期刊论文 | Zhen-Hua Chen;Kang Wang;Xiu-Ping Zhang;Jing-Kai Feng;Zong-Tao Chai;Wei-Xing Guo;Jie Shi;Meng-Chao Wu;Wan Yee Lau;Shu-Qun Cheng |
| 24 | Association of Preoperative Hypercoagulability with Poor Prognosis in Hepatocellular Carcinoma Patients with Microvascular Invasion After Liver Resection: A Multicenter Study | 期刊论文 | Xiu-Ping Zhang;Teng-Fei Zhou;Zhi-Heng Wang;Fan Zhang;Cheng-Qian Zhong;Yi-Ren Hu;Kang Wang;Zong-Tao Chai;Zhen-Hua Chen;Meng-Chao Wu;Wan Yee Lau;Shu-Qun Cheng |
| 25 | A deep learning model with incorporation of microvascular invasion area as a factor in predicting prognosis of hepatocellular carcinoma after R0 hepatectomy | 期刊论文 | Kang Wang;Yanjun Xiang;Jiangpeng Yan;Yuyao Zhu;Hanbo Chen;Hong-Ming Yu;Yu-Qiang Cheng;Xiu Li;Wei Dong;Yan Ji;Jingjing Li;Dong Xie;Wan Yee Lau;Jianhua Yao;Shu-Qun Cheng |
| 26 | All-trans-retinoic acid (ATRA) plus oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) versus FOLFOX alone as palliative chemotherapy in patients with advanced hepatocellular carcinoma and extrahepatic metastasis: study protocol for a randomized controlled trial | 期刊论文 | Jie Shi;Juxian Sun;Chang Liu;Zongtao Chai;Nanya Wang;Hui Zhang;Shuqun Cheng |
| 27 | Effects of Stereotactic Body Radiation Therapy Plus PD-1 Inhibitors for Patients With Transarterial Chemoembolization Refractory | 期刊论文 | Yan-Jun Xiang;Kang Wang;Yi-Tao Zheng;Shuang Feng;Hong-Ming Yu;Xiao-Wei Li;Xi Cheng;Yu-Qiang Cheng;Jin-Kai Feng;Li-Ping Zhou;Yan Meng;Jian Zhai;Yun-Feng Shan;Shu-Qun Cheng |
| 28 | Transarterial chemoembolization plus a PD‐1 inhibitor with or without lenvatinib for intermediate‐stage hepatocellular carcinoma | 期刊论文 | Yan-Jun Xiang;Kang Wang;Hong-Ming Yu;Xiao-Wei Li;Yu-Qiang Cheng;Wei-Jun Wang;Jin-Kai Feng;Meng-Han Bo;Ying-Yi Qin;Yi-Tao Zheng;Yun-Feng Shan;Li-Ping Zhou;Jian Zhai;Shu-Qun Cheng |
| 29 | Efficacy and Safety of Transarterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma Associated with Bile Duct Tumor Thrombus: A Real-World Retrospective Cohort Study | 期刊论文 | Jin-Kai Feng;Ju-Xian Sun;Zong-Han Liu;Jing-Wen Gu;Zhen-Hua Chen;Chang Liu;Wei-Xing Guo;Jie Shi;Shu-Qun Cheng |
| 30 | Prognostic Model for Identifying Candidates for Hepatectomy in Patients with Hepatocellular Carcinoma and Hepatic Vein Invasion | 期刊论文 | Xiu-Ping Zhang;Kang Wang;Yu-Zhen Gao;Xu-Biao Wei;Chong-De Lu;Zong-Tao Chai;Zuo-Jun Zhen;Jing Li;Ding-Hua Yang;Dong Zhou;Rui-Fang Fan;Mao-Lin Yan;Yi-Jun Xia;Bin Liu;Yang-Qing Huang;Fan Zhang;Yi-Ren Hu;Cheng-Qian Zhong;Jian-Hua Lin;Kun-Peng Fang;Zhen-Hua Chen;Meng-Chao Wu;Wan Yee Lau;Shu-Qun Cheng;for Chinese National Research Cooperative Group fo |
| 31 | Association of type 2 diabetes mellitus with incidences of microvascular invasion and survival outcomes in hepatitis B virus-related hepatocellular carcinoma after liver resection: A multicenter study | 期刊论文 | Xiu-Ping Zhang;Zong-Tao Chai;Jin-Kai Feng;Hui-Min Zhu;Fan Zhang;Yi-Ren Hu;Cheng-Qian Zhong;Zhen-Hua Chen;Kang Wang;Jie Shi;Wei-Xing Guo;Chao-Shuang Chen;Meng-Chao Wu;Wan Yee Lau;Shu-Qun Cheng |
| 32 | Liver resection versus intensity-modulated radiation therapy for treatment of hepatocellular carcinoma with hepatic vein tumor thrombus: a propensity score matching analysis | 期刊论文 | Zhen-Hua Chen;Xiu-Ping Zhang;Shuang Feng;Jing-Kai Feng;Zong-Tao Chai;Wei-Xing Guo;Jie Shi;Wan Yee Lau;Yan Meng;Shu-Qun Cheng |
| 33 | A novel classification in predicting prognosis and guiding postoperative management after R0 liver resection for patients with hepatocellular carcinoma and microvascular invasion | 期刊论文 | Kang Wang;Yan-Jun Xiang;Hong-Ming Yu;Yu-Qiang Cheng;Ying-Yi Qin;Wei-Jun Wang;Xiu-Ping Zhang;Yi-Tao Zheng;Yun-Feng Shan;Wen-Ming Cong;Hui Dong;Wan Yee Lau;Shu-Qun Cheng |
| 34 | Postoperative adjuvant transarterial chemoembolization improves outcomes of hepatocellular carcinoma associated with bile duct tumor thrombus: a propensity score matching analysis | 期刊论文 | Zhen-Hua Chen;Jin-Kai Feng;Ju-Xian Sun;Jia-Yi Wu;Wei-Xing Guo;Jie Shi;Yong-Gang Wei;Jian-Yin Zhou;Zhi-Bo Zhang;Mao-Lin Yan;Shu-Qun Cheng |
| 35 | A panel of five plasma proteins for the early diagnosis of hepatitis B virus-related hepatocellular carcinoma in individuals at risk | 期刊论文 | Kai Cheng;Jie Shi;Zixin Liu;Yin Jia;Qin Qin;Hui Zhang;Siqin Wan;Ziguang Niu;Lei Lu;Ju-Xian Sun;Jie Xue;Chongde Lu;Xu-Biao Wei;Lei Guo;Fan Zhang;Dong Zhou;Yufu Tang;Yi-Ren Hu;Yangqing Huang;Yang Chen;Wan Yee Lau;Shu-Qun Cheng;Shanrong Liu |
| 36 | Hepatocellular Carcinoma with Portal Vein Tumor Thrombus versus Hepatocellular Carcinoma with Biliary Tumor Thrombus: Better or Worse Prognoses? [Letter] | 期刊论文 | Jin-Kai Feng;Ju-Xian Sun;Zong-Han Liu;Shu-Qun Cheng |
| 37 | Hazard rate for postoperative recurrence in patients with hepatocellular carcinoma at Barcelona Clinic Liver Cancer stage 0 or A1: A multicenter observational study | 期刊论文 | Yan-Jun Xiang;Kang Wang;Hong-Ming Yu;Miao-Miao Wang;Le-Qun Li;Hui-Chuan Sun;Tian-Fu Wen;Yu-Qing Zhang;Yun-Feng Shan;Li-Ping Zhou;Shu-Qun Cheng |
| 38 | NET1 promotes HCC growth and metastasis in vitro and in vivo via activating the Akt signaling pathway | 期刊论文 | Zhen-Hua Chen;Qian-Zhi Ni;Xiu-Ping Zhang;Ning Ma;Jing-Kai Feng;Kang Wang;Jing-Jing Li;Dong Xie;Xing-Yuan Ma;Shu-Qun Cheng |
| 39 | Adjuvant transarterial chemoembolization improves survival outcomes in hepatocellular carcinoma with microvascular invasion: Asystematic review and meta-analysis | 期刊论文 | Zhen-Hua Chen;Xiu-Ping Zhang;Teng-Fei Zhou;Kang Wang;Hang Wang;Zong-Tao Chai;Jie Shi;Wei-Xing Guo;Shu-Qun Cheng |
| 40 | All-Trans-Retinoic Acid Plus Oxaliplatin/Fluorouracil/Leucovorin for Advanced Hepatocellular Carcinoma with Pulmonary Metastasis: A Multicenter Retrospective Study | 期刊论文 | Juxian Sun;Chang Liu;Nanya Wang;Dafeng Jiang;Fan Zhang;Jie Shi;Shuqun Cheng |
| 41 | A nomogram to predict early postoperative recurrence of hepatocellular carcinoma with portal vein tumour thrombus after R0 liver resection: A large-scale, multicenter study | 期刊论文 | Xiu-Ping Zhang;Zhen-Hua Chen;Teng-Fei Zhou;Le-Qun Li;Min-Shan Chen;Tian-Fu Wen;Jie Shi;Wei-Xing Guo;Meng-Chao Wu;Wan Yee Lau;Shu-Qun Cheng |
| 42 | Postoperative Adjuvant Transarterial Chemoembolization Improves Outcomes of Hepatocellular Carcinoma Associated with Hepatic Vein Invasion: A Propensity Score Matching Analysis | 期刊论文 | Xiu-Ping Zhang;Yan-Chen Liu;Zhen-Hua Chen;Ju-Xian Sun;Kang Wang;Zong-Tao Chai;Jie Shi;Wei-Xing Guo;Meng-Chao Wu;Wan Yee Lau;Shu-Qun Cheng |
| 43 | Effect of microvascular invasion on the postoperative long-term prognosis of solitary small HCC: a systematic review and meta-analysis | 期刊论文 | Zhen-Hua Chen;Xiu-Ping Zhang;Hang Wang;Zong-Tao Chai;Ju-Xian Sun;Wei-Xing Guo;Jie Shi;Shu-Qun Cheng |
| 44 | Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study | 期刊论文 | Xu-Biao Wei;Ya-Bo Jiang;Xiu-Ping Zhang;Feng Shuang;Bin Zhou;Xiaofei Ye;Hui Xing;Ying Xu;Jie Shi;Wei-Xing Guo;Dong Zhou;Hui Zhang;Hui-Chuan Sun;Cheng Huang;Congde Lu;Yaxin Zheng;Yan Meng;Bin Huang;Wen-Ming Cong;Wan Yee Lau;Shu-Qun Cheng |
| 45 | Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma. | 期刊论文 | Yabo Jiang;Yongzhen Tao;Xiuping Zhang;Xubiao Wei;Min Li;Xuxiao He;Bin Zhou;Weixing Guo;Huiyong Yin;Shuqun Cheng |
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