多环天然产物合成中的复杂环系构建

21290183
2012
B0703.天然产物化学生物学
翟宏斌
重大项目
教授
兰州大学
355万元
Aldol;反应;[4+3];环加成;仿生合成;Prins;环化;电环化反应
2013-01至2017-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Total Synthesis of Dictyodendrins B and E 期刊论文 Jingjing Liang;Weimin Hu;Pengyu Tao;Yanxing Jia
2 Formal Synthesis of (+)-Kopsihainanine A and Synthetic Study toward (+)-Limaspermidine 期刊论文 Zhuang Chen,Shiqiang Zhou,Yanxing Jia
3 Blue-light-promoted carbon–carbon double bond isomerization and its application in the syntheses of quinolines 期刊论文 Xinzheng Chen,Shuxian Qiu,Sasa Wang,Huifei Wang,Hongbin Zhai
4 Formal Synthesis of (±)-Aplykurodinone‑1 through a Hetero- Pauson−Khand Cycloaddition Approach 期刊论文 Cheng Tao,Jing Zhang,Xiaoming Chen,Huifei Wang,Yun Li,Bin Cheng,Hongbin Zhai
5 Total Synthesis of (-)-Goniomitine 期刊论文 Shiqiang Zhou,Yanxing Jia
6 A palladium-catalyzed intramolecular carbonylative annulation reaction for the synthesis of 4,5-fused tricyclic 2-quinolones 期刊论文 Xiwu Zhang;Haichao Liu;Yanxing Jia
7 3,4-桥环吲哚类生物碱的合成研究进展 期刊论文 单 冬,贾彦兴
8 Ag-Carbenoid-Initiated Catalytic Hydration Cascades: Rapid Construction of Functionalized Bicyclo[3.3.1]nonanes 期刊论文 Lu Wang;Shunyou Cai;Xiangyou Xing;Ying Gao;Tao Wang;David Zhigang Wang
9 Catalytic Asymmetric Total Synthesis of (-)-Galanthamine and (-)-Lycoramine 期刊论文 Lei Li;Qiao Yang;Yuan Wang;Yanxing Jia
10 Synthesis of the cycloheptannelated indole fragment of dragmacidin E 期刊论文 Bin Wang;Hua Qin;Fengying Zhang;Yanxing Jia
11 Decarboxylative Csp3–Csp3 coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols 期刊论文 Sasa Wang,Xinzheng Chen,Qiaoqiao Ao,Huifei Wang,Hongbin Zhai
12 A Simple and Efficient Synthesis of Secondary Alkylamines from Nitroalkanes 期刊论文 Zhi Huang; Jianbo Lv; Yanxing Jia
13 lVettiersible Light Induced Photocatalytic Conversion of Enamines into Amides 期刊论文 Jing Li,Shunyou Cai,Jietao Chen,Yaohong Zhao,David Zhigang Wang
14 A concise gram-scale synthesis of ht-13-A via a rhodium-catalyzed intramolecular C–H activation reaction 期刊论文 Pengyu Tao; Zhuang Chen; Yanxing Jia
15 Visible-light photo-catalytic CeC bond cleavages: preparations of N,N-dialkylformamides from 1,2-vicinal diamines 期刊论文 Yaohong Zhao,Shunyou Cai,Jing Li,David Zhigang Wang
16 Rhodium-Catalyzed Denitrogenative [3+2] Cycloaddition: Access to Functionalized Hydroindolones and the Framework of Montanine-Type Amaryllidaceae Alkaloids 期刊论文 Yang Hongjian();Hou Shengtai;Tao Cheng;Liu Zhao;Wang Chao;Cheng Bin;Li Yun();Zhai Hongbin()
17 Reagent-free synthesis of 2,3,4-polysubstituted tetrahydroquinolines: application to the formal synthesis of (±)-martinellic acid and martinelline 期刊论文 Zhouting Rong,Qingjiang Li,Wenhan Lin,Yanxing Jia
18 Rh-Catalyzed [3 + 2] Cycloaddition of 1‑Sulfonyl-1,2,3-triazoles: Access to the Framework of Aspidosperma and Kopsia Indole Alkaloids 期刊论文 Yun Li,Qingyu Zhang,Qiucheng Du,Hongbin Zhai
19 Construction of the A ring of halichomycin via a RCM strategy 期刊论文 Mao Shiyong;Jia Yanxing
20 Silver(I)-Catalyzed Ring-Contractive Rearrangement: A New Entry to 5‑Alkylidene-2-cyclopentenones 期刊论文 Zhao Liang;Wang Jinlian;Zheng Hongyan;Li Yun;Yang Ke;Cheng Bin;Jin Xiaojie;Yao Xiaojun;Zhai Hongbin
21 Structure-based design of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3b inhibitors to activate Wnt/b-catenin pathway 期刊论文 Hong Yue;Feng Lu;Chen Shen;Jun-Min Quan
22 Gold-Catalyzed Rearrangement of Alkynyl Donor−Acceptor Cyclopropanes To Construct Highly Functionalized Alkylidenecyclopentenes 期刊论文 Huiyu Chen;Jing Zhang;David Zhigang Wang
23 A One-Pot Synthesis of Dibenzofurans from 6‑Diazo-2- cyclohexenones 期刊论文 Hua Zhao,Ke Yang,Hongyan Zheng,Ruichao Ding,Fangjie Yin,Ning Wang,Yun Li,Bin Cheng,Huifei Wang,Hongbin Zhai
24 Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy 期刊论文 Wei Hongbo();Li Yun;Xiao Ke;Cheng Bin;Zhai Hongbin;Wang Huifei;Zhai Hongbin;Hu Lin;Zhai Hongbin;Li Y()
25 Crystal structure of the polo-box domain of polo-like kinase 2 期刊论文 Hong-Mei Shan; Tao Wang; Jun-Min Quan
26 A new approach to arylhydrazides via the reaction of the Mitsunobu reagent with arynes: further application to access diverse nitrogen-containing heterocycles in one pot 期刊论文 Cheng Bin()();Bao Bian;Chen Yanhe;Wang Ning;Li Yun;Wang Renqi;Zhai Hongbin;Zhai Hongbin;Zhai Hongbin;Cheng B();Zhai HB();Zhai HB();Zhai HB()
27 Protecting-Group-Free Enantioselective Synthesis of (-)-Pallavicinin and (+)-Neopallavicinin 期刊论文 Bin Huang; Lei Guo; Yanxing Jia
28 Palladium-catalyzed synthesis of benzofurans via C–H activation/oxidation tandem reaction and its application to the synthesis of decursivine and serotobenine 期刊论文 Lei Guo,Fengying Zhang,Weimin Hu,Lei Li,Yanxing Jia
29 Visible-Light-Promoted Photoredox Syntheses of α,β-Epoxy Ketones from Styrenes and Benzaldehydes under Alkaline Conditions 期刊论文 Jing Li;David Zhigang Wang
30 1,2,4-三取代或2,4-二取代吡咯环制备方法 专利 贾彦兴
31 N,N-Dimethylaminobenzoates enable highly enantioselective Sharpless dihydroxylations of 1,1-disubstituted alkenes 期刊论文 Yaohong Zhao,Xiangyou Xing,Shaolong Zhang,David Zhigang Wang
32 Total Synthesis of Dictyodendrins B and E, and Formal Synthesis of Dictyodendrin C 期刊论文 Pengyu Tao;Jingjing Liang;Yanxing Jia
33 Total Syntheses of Naucleamides A−C and E, Geissoschizine, Geissoschizol, (E)‑Isositsirikine, and 16-epi-(E)‑Isositsirikine 期刊论文 Lei Li;Paruke Aibibula;Qianlan Jia;Yanxing Jia
34 Concise synthesis of the tricyclic skeleton of crotobarin and crotogoudin via a gold-catalyzed cycloisomerization reaction 期刊论文 Yinliang Guo;Qiang Liu;Yanxing Jia
35 加兰他敏和力可拉敏的不对称合成方法 专利 周其林;谢建华;陈继强;王立新
36 Total Syntheses of Festuclavine, Pyroclavine, Costaclavine, epi-Costaclavine, Pibocin A, 9-Deacetoxyfumigaclavine C, Fumigaclavine G, and Dihydrosetoclavine 期刊论文 Liu Haichao;Zhang Xiwu;Shan Dong;Pitchakuntla Mallesham;Ma Yongfan;Jia Yanxing()
37 A Chemoselective N‑Arylation Reaction of 2‑Aminopyridine Derivatives with Arynes 期刊论文 Bin Cheng,Jian Wei,Bing Zu,Jianfei Zhao,Taimin Wang,Xiaoguang Duan,Renqi Wang,Yun Li,Hongbin Zhai
38 Identification of Green Tea Catechins as Potent Inhibitors of the Polo-Box Domain of Polo-Like kinase 1 期刊论文 Shan Hong-Mei;Shi Yanxia;Quan Junmin()
39 Rhodium-catalyzed intramolecular annulation via C-H activation leading to fused tricyclic indole scaffolds 期刊论文 Pengyu Tao,Yanxing Jia
40 Asymmetric total synthesis of 3-epi-naucleamide A 期刊论文 Paruke Aibibula; Zhi Huang; Hongzheng Fu; Yanxing Jia
41 Intramolecular Larock indole synthesis for the preparation of tricyclic indoles and its application in the synthesis of tetrahydropyrroloquinoline and fargesine 期刊论文 Yan Gao;Dong Shan;Yanxing Jia
42 Structural basis for the inhibition of Polo-like kinase 1 期刊论文 Xu Jun;Shen Chen;Wang Tao;Quan Junmin
43 Visible-Light-Promoted Vinylation of Tetrahydrofuran with Alkynes through Direct C−H Bond Functionalization 期刊论文 Jing Li;David Zhigang Wang;Haibo Tan;Jing Zhang
44 Asymmetric Synthesis of the Tricyclic Core of Calyciphylline A‑Type Alkaloids via Intramolecular [3 + 2] Cycloaddition 期刊论文 Lu Wang,Chen Xu,Li Chen,Xiaojiang Hao,David Zhigang Wang
45 Intramolecular Larock Indole Synthesis: Preparation of 3,4-Fused Tricyclic Indoles and Total Synthesis of Fargesine 期刊论文 Shan Dong;Gao Yan;Jia Yanxing
46 Divergent Total Syntheses of ()-Daphnilongeranin B and ()-Daphenylline 期刊论文 Xiaoming Chen,Hai-Jun Zhang,Xinkan Yang,Houqiang Lv,Xiaoru Shao,Cheng Tao,Huifei Wang,Bin Cheng,Yun Li,Hongbin Zhai
47 Direct Access to Tetrahydro[1,2]diazepinones from r,β-Epoxy‑N‑aziridinylimines via Anionic Rearrangement 期刊论文 Fufang Wu,Min Dong,Fang Fang,Yingxia Sang,Yun Li,Bin Cheng,Lihe Zhang,Hongbin Zhai
48 C–H bond activation in the total syntheses of natural products 期刊论文 Pengyu Tao; Yanxing Jia
49 CuCl2/TBHP-mediated direct chlorooxidation of indoles 期刊论文 Wang Huifei;Liu Dong;Chen Huiyu;Li Jing;Wang David Zhigang
50 Total Synthesis of Rugulovasine A 期刊论文 Yu-An Zhang;Qiang liu;Chao Wang;Yanxing Jia
51 Gram Scale Syntheses of (−)-Incarvillateine and Its Analogs. Discovery of Potent Analgesics for Neuropathic Pain 期刊论文 Bin Huang;Fengying Zhang;Gang Yu;Yan Song;Xintong Wang;Meiliang Wang;Zehui Gong;Ruibin Su;Yanxing Jia
52 Total Synthesis of the Diterpenoid (+)-Harringtonolide 期刊论文 Hai-Jun Zhang;Lin hu;zhiqiang Ma;Ruining Li;Zhen Zhang;Cheng Tao;Bin Cheng;Yun Li;Huifei Wang;Hongbin Zhai
53 Synthesis of Spiro[indazole-3,3′-indolin]-2′-ones via [3 + 2] Dipolar Cycloaddition of Arynes with 3‑Diazoindolin-2-ones and Indazolo[2,3‑c]quinazolin-6(5H)‑ones by Subsequent Thermal Isomerization 期刊论文 Bin Cheng,Bing Zu,Bian Bao,Yun Li,Renqi Wang,Hongbin Zhai
54 New Approach to Oximes through Reduction of Nitro Compounds Enabled by Visible Light Photoredox Catalysis 期刊论文 Cai Shunyou;Zhang Shaolong;Zhao Yaohong;Wang David Zhigang
55 角蒿酯碱类似物以及其在镇痛中的应用 专利 贾彦兴
56 Asymmetric Total Synthesis of (+)-Dragmacidin D Reveals Unexpected Stereocomplexity 期刊论文 Fengying Zhang;Bin Wang;Pritesh Prasad;Robert J. Capon;Yanxing Jia
57 Crystal structure of the death effector domains of caspase-8 期刊论文 Shen Chen;Yue Hong;Pei Jianwen;Guo Xiaomin;Wang Tao();Quan Jun-Min()
58 Total synthesis of (þ)-gelsemine via an organocatalytic Diels–Alder approach 期刊论文 Xiaoming Chen,Shengguo Duan,Cheng Tao,Hongbin Zhai,Fayang G. Qiu
59 Total synthesis of (−)-decursivine and analogues via cascade sequence 期刊论文 Fengying Zhang; Lei Guo; Weimin Hu; Yanxing Jia
60 Total Synthesis of (+)- and ()-Decursivine and ()-Serotobenine through a CascadeWitkop Photocyclization/Elimination/Addition Sequence: Scope and Mechanistic Insights 期刊论文 Weimin Hu,Hua Qin,Yuxin Cui,Yanxing Jia
61 Synthetic studies of cyclic peptides stephanotic acid methyl ester, celogentin C, and moroidin 期刊论文 Lei Li; Weimin Hu; Yanxing Jia
62 Total Synthesis of (+)-Lysergic Acid 期刊论文 Liu Qiang;Zhang Yu-An;Xu Ping;Jia Yanxing
63 Asymmetric Total Synthesis of (−)-Aspidophylline A 期刊论文 Taimin Wang,Xiaoguang Duan,Hua Zhao,Shengxian Zhai,Cheng Tao,Huifei Wang,Yun Li,Bin Cheng,Hongbin Zhai
64 Direct Olefination at the C‑4 Position of Tryptophan via CH Activation: Application to Biomimetic Synthesis of Clavicipitic Acid 期刊论文 Qiang Liu,Qingjiang Li,Yongfan Ma,Yanxing Jia
65 New reactivity of ethynyl benziodoxolone: modulating iron-catalyzed dehydration of propargyl alcohols 期刊论文 Chen Huiyu;Shao Xiaoru;Wang Huifei;Zhai Hongbin
66 Ortho-Dearomatization of Phenols Creating All-Carbon Spiro-Bicycles 期刊论文 Zheng Chao;Wang Lu;Li Jingjie;Wang Leifeng;Wang David Zhigang
67 Regioselective Direct C-4 Functionalization of Indole: Total Syntheses of (–)-Agroclavine and (–)-Elymoclavine 期刊论文 Jianbo Lv;Bin Wang;Kuo Yuan;Yuan Wang;Yanxing Jia
68 Gold Catalysis Coupled with Visible Light Stimulation: Syntheses of Functionalized Indoles 期刊论文 Cai Shunyou;Yang Kai;Wang David Zhigang
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