哺乳动物DNA甲基化表观遗传的核心机制与功能研究
31730048
2017
C0601.遗传物质结构与功能
翁杰敏
重点项目
教授
华东师范大学
316万元
组蛋白泛素化;甲基化;DNA维持性甲基化;DNA;DNA修饰酶;去泛素化酶7
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function | 期刊论文 | Huang Yuanyong;Duan Xiaoya;Wang Zhen;Sun Yimei;Guan Qingqing;Kang Li;Zhang Qiao;Fang Lan;Li Jiwen;Wong Jiemin |
| 2 | Mutation-induced DNMT1 cleavage drives neurodegenerative disease | 期刊论文 | Wang Wencai;Zhao Xingsen;Shao Yanjiao;Duan Xiaoya;Wang Yaling;Li Jialun;Li Jiwen;Li Dali;Li Xuekun;Wong Jiemin |
| 3 | USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment | 期刊论文 | Li Jialun;Wang Ruiping;Jin Jianyu;Han Mengmeng;Chen Zhaosu;Gao Yingying;Hu Xueli;Zhu Haijun;Gao Huifang;Lu Kongbin;Shao Yanjiao;Lyu Cong;Lai Weiyi;Li Pishun;Hu Guang;Li Jiwen;Li Dali;Wang Hailin;Wu Qihan;Wong Jiemin |
| 4 | SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1 | 期刊论文 | Zhang Huifang;Gao Qinqin;Tan Shuo;You Jia;Lyu Cong;Zhang Yunpeng;Han Mengmeng;Chen Zhaosu;Li Jialun;Wang Hailin;Liao Lujian;Qin Jun;Li Jiwen;Wong Jiemin |
| 5 | SUMOylation down-regulates rDNA transcription by repressing expression of upstream-binding factor and proto-oncogene c-Myc | 期刊论文 | Peng Yu;Wang Zhenxing;Wang Zhiqiang;Yu Fang;Li Jiwen;Wong Jiemin |
| 6 | Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z | 期刊论文 | Chen Zhaosu;Zhang Yunpeng;Guan Qingqing;Zhang Huifang;Luo Jing;Li Jialun;Wei Wei;Xu Xiang;Liao Lujian;Wong Jiemin;Li Jiwen |
| 7 | Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function | 期刊论文 | Xu Xiang;Ding Guangjin;Liu Caizhi;Ding Yuhan;Chen Xiaoxin;Huang Xiaoli;Zhang Chen-Song;Lu Shanxin;Zhang Yunpeng;Huang Yuanyong;Chen Zhaosu;Wei Wei;Liao Lujian;Lin Shu-Hai;Li Jingya;Liu Wei;Li Jiwen;Lin Sheng-Cai;Ma Xinran;Wong Jiemin |
| 8 | Activated MEK/ERK Pathway Drives Widespread and Coordinated Overexpression of UHRF1 and DNMT1 in Cancer cells | 期刊论文 | Li Jialun;Wang Ruiping;Hu Xueli;Gao Yingying;Wang Zhen;Li Jiwen;Wong Jiemin |
| 9 | A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association. | 期刊论文 | Han Mengmeng;Li Jialun;Cao Yaqiang;Huang Yuanyong;Li Wen;Zhu Haijun;Zhao Qian;Han Jing-Dong Jackie;Wu Qihan;Li Jiwen;Feng Jing;Wong Jiemin |
| 10 | Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis | 期刊论文 | Duan Xiaoya;Huang Yuanyong;Chen Xiaoxing;Wang Wencai;Chen Jiwei;Li Jialun;Yang Wei;Li Jiwen;Wu Qihan;Wong Jiemin |
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