神经退行性疾病的分析新方法研究

21635003
2016
B04.化学测量学
田阳
重点项目
教授
华东师范大学
294万元
微纳电极与纳米孔电极;神经退行性疾病;细胞成像与生物传感;活体在体分析;分子间相互作用
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种检测高半胱氨酸的比率型荧光探针的制备方法及其在细胞成像与生物传感中的应用 专利 张琪伟;田阳;韩玉界
2 Development of an Efficient Biosensor for the In Vivo Monitoring of Cu and pH in the Brain: Rational Design and Synthesis of Recognition Molecules 期刊论文 Liu Wei;Dong Hui;Zhang Limin;Tian Yang
3 一种新型光敏剂纳米颗粒的制备方法和应用 专利 张琪伟;田阳;童星雨
4 Designing Recognition Molecules and Tailoring Functional Surfaces for In Vivo Monitoring of Small Molecules in the Brain 期刊论文 Zhan Limin;Tian Yang
5 Long-term tracking and dynamically quantifying of reversible changes of extracellular Ca2+ in multiple brain regions of freely moving animals 期刊论文 Liu Yuandong;Liu Zhichao;Zhao Fan;Tian Yang
6 时间分辨型荧光材料在检测抗坏血酸含量上的应用 专利 张闽;韩欣悦;施国跃;陈子晗;李康妮
7 Recent advances in development of devices and probes for sensing and imaging in the brain 期刊论文 Liu Zhichao;Tian Yang
8 Functionalized h-BN Nanosheets as a Theranostic Platform for SERS Real-Time Monitoring of MicroRNA and Photodynamic Therapy 期刊论文 Liu Jia;Zheng Tingting;Tian Yang
9 Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid beta 期刊论文 Lai Yi;Zhu Yingying;Xu Zhiai;Hu Xianli;Saeed Madiha;Yu Haijun;Chen Xingxing;Liu Jun;Zhang Wen
10 Wettability Switching of Electrode for Signal Amplification: Conversion of Conformational Change of Stimuli-Responsive Polymer into Enhanced Electrochemical Chiral Analysis 期刊论文 Ding Shushu;Cao Sumei;Zhu Anwei;Shi Guoyue
11 通过分子线调控纳米界面用于UA 检测的电化学传感器及其制备和应用 专利 田阳;张立敏;钱银洁
12 Highly stable electrochemical probe with bidentate thiols for ratiometric monitoring of endogenous polysulfide in living mouse brains 期刊论文 Qian yinjie;Zhang Limin;Tian Yang
13 一种比率型离子选择性微电极阵列及其制备方法和应用 专利 田阳;赵凡
14 Multifunctional peptide-assembled micelles for simultaneously reducing amyloid-β and reactive oxygen species 期刊论文 Lei Li;Zou Zhifeng;Liu jin;Xu Zhiai;Fu Ying;Tian Yang;Zhang Wen
15 An integrated platform for the capture of circulating tumor cells and in situ SERS profiling of membrane proteins through rational spatial organization of multi-functional cyclic RGD nanopatterns 期刊论文 Dong Hui;Yao Dazhi;Zhou Qi;Zhang Limin;Tian Yang
16 Rational Design of Stimuli-Responsive Polymers Modified Nanopores for Selective and Sensitive Determination of Salivary Glucose 期刊论文 Yang Miao;Ma Chunrong;Ding Shushu;Zhu Yujie;Shi Guoyue;Zhu Anwei
17 Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity 期刊论文 Ding Chunyong;Wang Fengyang;Dang Yijing;Xu Zhiai;Li Lingling;Lai Yi;Yu Haijun;Luo Yi;Huang Ruimin;Zhang Ao;Zhang Wen
18 Engineering Carbon Nanotube Fiber for Real-Time Quantification of Ascorbic Acid Levels in a Live Rat Model of Alzheimer's Disease 期刊论文 Zhang Limin;Liu Fangling;Sun Xuemei;Wei Guang-feng;Tian Yang;Liu Zhi-pan;Huang Rong;Yu Yanyan;Peng Huisheng
19 A dual-mode nanoprobe for evaluation of the autophagy level affected by photothermal therapy 期刊论文 Liu Jia;Qu Yining;Zheng Tingting;Tian Yang
20 A Robust Au-C equivalent to C Functionalized Surface: Toward Real-Time Mapping and Accurate Quantification of Fe(2+)in the Brains of Live AD Mouse Models 期刊论文 Zhang Chuanping;Liu Zhichao;Zhang Limin;Zhu Anwei;Liao Fumin;Wan Jingjing;Zhou Jian;Tian Yang
21 Real-time monitoring of peroxynitrite (ONOO-) in the rat brain by developing a ratiometric electrochemical biosensor 期刊论文 Liu Feiyue;Dong Hui;Tian Yang
22 Mitochondria-Targeted DNA Nanoprobe for Real-Time Imaging and Simultaneous Quantification of Ca2+ and pH in Neurons 期刊论文 Liu Zhichao;Pei Hao;Zhang Limin;Tian Yang
23 Enantiomers of Single Chirality Nanotube as Chiral Recognition Interface for Enhanced Electrochemical Chiral Analysis 期刊论文 Pu Chunling;Xu Yunxia;Liu Qi;Zhu Anwei;Shi Guoyue
24 In situ detection of hydroxyl radicals in mitochondrial oxidative stress with a nanopipette electrode. 期刊论文 Wenting Chen;Shushu Ding;Jiaren Wu;Guoyue Shi;Anwei Zhu
25 Pillar[5]arene-based fluorescent sensor array for biosensing of intracellular multi-neurotransmitters through host-guest recognition 期刊论文 Mei Yuxiao;Zhang Qiwei;Gu Qingyi;Liu Zhichao;He Xiao;Tian Yang
26 A ratiometric fluorescent DNA nanoprobe for cerebral adenosine triphosphate assay 期刊论文 Liu Zhichao;Wu Peicong;Yin Yaoyao;Tian Yang
27 Glycopeptide Nanofiber Platform for A beta-Sialic Acid Interaction Analysis and Highly Sensitive Detection of A beta 期刊论文 Lei Li;Geng Rui;Xu Zhiai;Dang Yijing;Hu Xianli;Li Lingling;Geng Ping;Tian Yang;Zhang Wen
28 A highly stable two-photon ratiometric fluorescence probe for real-time biosensing and imaging of nitric oxide in brain tissues and larval zebrafish 期刊论文 Gong Zhiwen;Liu Zhichao;Zhang Zhonghui;Mei Yuxiao;Tian Yang
29 一种包裹有抗生物蛋白污染氧化石墨烯微带的碳纤维/镀金碳纤维电极及其制备方法和应用 专利 田阳;刘原东
30 A novel ternary heterostructure with dramatic SERS activity for evaluation of PD-L1 expression at the single-cell level 期刊论文 Feng Enduo;Zheng Tingting;He Xiaoxiao;Chen Jinquan;Tian Yang
31 Mitochondria-Targeted Ratiometric Fluorescent Nanosensor for Simultaneous Biosensing and Imaging of O-2(center dot-) and pH in Live Cells 期刊论文 Huang Hong;Dong Fangyuan;Tian Yang
32 A novel two-photon ratiometric fluorescent probe for imaging and sensing of BACE1 in different regions of AD mouse brain 期刊论文 Ge Lihong;Liu Zhichao;Tian Yang
33 Noninvasive In Situ Ratiometric Imaging of Biometals Based on Self-Assembled Peptide Nanoribbon 期刊论文 Lei Li;Li Min;Wu Sufen;Xu Zhiai;Geng Ping;Tian Yang;Fu Ying;Zhang Wen
34 一种可逆的Ca2+识别配体METH及其制备方法和应用 专利 田阳;刘原东;张立敏
35 一种PD-L1探针及其制备方法和应用 专利 冯恩铎;田阳;郑婷婷
36 I-motif Formed at Physiological pH Triggered by Spatial Confinement of Nanochannels: An Electrochemical Platform for pH Monitoring in Brain Microdialysates 期刊论文 Shi Lu;Cao Feifei;Zhang Limin;Tian Yang
37 Time-space-resolved origami hierarchical electronics for ultrasensitive detection of physical and chemical stimuli 期刊论文 Zhang Min;Sun Jiaxing Jeccy;Khatib Muhammad;Lin Zi-Yang;Chen Zi-Han;Saliba Walaa;Gharra A'laa;Horev Yehu David;Kloper Viki;Milyutin Yana;Tan-Phat Huynh;Brandon Simon;Shi Guoyue;Haick Hossam
38 Raman fiber photometry for understanding mitochondrial superoxide burst and extracellular calcium ion influx upon acute hypoxia in the brain of freely moving animals 期刊论文 Liu Zhichao;Zhang Zhonghui;Liu Yuandong;Mei Yuxiao;Feng Enduo;Liu Yangyi;Zheng Tingting;Chen jingxuan;Zhang Sanjun;Tian Yang
39 DNA Encountering Terbium(III): A Smart "Chemical Nose/Tongue" for Large-Scale Time-Gated Luminescent and Lifetime-Based Sensing 期刊论文 Xue Shi-Fan;Chen Zi-Han;Han Xin-Yue;Lin Zi-Yang;Wang Qi-Xian;Zhang Min;Shi Guoyue
40 一种高重现性表面增强拉曼光谱平台的构建及其应用 专利 田阳;张立敏;石璐
41 Light-Controlled Generation of Singlet Oxygen within a Discrete Dual-Stage Metallacycle for Cancer Therapy 期刊论文 Qin Yi;Chen Li-Jun;Dong Fangyuan;Jiang Shu-Ting;Yin Guang-Qiang;Li Xiaopeng;Tian Yang;Yang Hai-Bo
42 A comprehensive study on the generation of reactive oxygen species in Cu-A beta-catalyzed redox processes 期刊论文 Huang Hong;Lou Xiaobing;Hu Bingwen;Zhou Zhongneng;Chen Jinquan;Tian Yang
43 Two-photon fluorescent Zn2+ probe for ratiometric imaging and biosensing of Zn2+ in living cells and larval zebrafish 期刊论文 Li Wanying;Liu Zhichao;Fang Bingqing;Jin Ming;Tian Yang
44 A ratiometric fluorescent probe for bioimaging and biosensing of HBrO in mitochondria upon oxidative stress 期刊论文 Huang Hong;Tian Yang
45 一种DNA银纳米簇及其细胞原位的合成方法和应用 专利 田阳;董方圆;郑婷婷
46 A SERS Optophysiological Probe for the Real-Time Mapping and Simultaneous Determination of the Carbonate Concentration and pH Value in a Live Mouse Brain 期刊论文 Wang Weikang;Zhao Fan;Li Mingzhi;Zhang Chuanping;Shao Yuanhua;Tian Yang
47 Sensitive and Selective Measurement of Hydroxyl Radicals at Subcellular Level with Tungsten Nanoelectrodes 期刊论文 Ding Shushu;Li Meina;Gong Haoyang;Zhu Qing;Shi Guoyue;Zhu Anwei
48 Biomimetic Mineralization of Gold Nanoclusters as Multifunctional Thin Films for Glass Nanopore Modification, Characterization, and Sensing 期刊论文 Cao Sumei;Ding Shushu;Liu Yingzi;Zhu Anwei;Shi Guoyue
49 Bioimaging and Biosensing of Ferrous Ion in Neurons and HepG2 Cells upon Oxidative Stress 期刊论文 Liu Zhichao;Wang Shengnan;Li Wanying;Tian Yang
50 一种同时检测Cu+和Cu2+的表面增强拉曼光谱探针及其制备方法和应用 专利 田阳;刘嘉麒;刘蒙蒙
51 Nonenzymatic electrochemical sensor with ratiometric signal output for selective determination of superoxide anion in rat brain 期刊论文 Huang Shiqi;Zhang Limin;Dai Liyi;Wang Yuanyuan;Tian Yang
52 Acid-Promoted D-A-D Type Far-Red Fluorescent Probe with High Photostability for Lysosomal Nitric Oxide Imaging 期刊论文 Wang Fengyang;Yu Shujuan;Xu Zhiai;Li Lingling;Dang Yijing;Xu Xiaowei;Luo Yi;Cheng Zhen;Yu Haijun;Zhang Wen;Zhang Ao;Ding Chunyong
53 Coordination of ligand-protected metal nanoclusters and glass nanopipettes: conversion of a liquid-phase fluorometric assay into an enhanced nanopore analysis 期刊论文 Ding Shushu;Liu Chunyan;Fu Dingyi;Shi Guoyue;Zhu Anwei
54 A Copper Nanocluster-Based Fluorescent Probe for Real-Time Imaging and Ratiometric Biosensing of Calcium Ions in Neurons 期刊论文 Liu Zhichao;Jing Xia;Zhang Sanjun;Tian Yang
55 Rational Design of Specific Recognition Molecules for Simultaneously Monitoring of Endogenous Polysulfide and Hydrogen Sulfide in the Mouse Brain 期刊论文 Dong Hui;Zhou Qi;Zhang Limin;Tian Yang
56 Fluorescence Lifetime Imaging of p-tau Protein in Single Neuron with a Highly Selective Fluorescent Probe 期刊论文 Ge Lihong;Tian Yang
57 Real-time tracking and sensing of Cu+ and Cu2+ with a single SERS probe in the live brain: toward understanding why copper ions were increased upon ischemia 期刊论文 Liu Jiaqi;Liu Zhichao;Wang Weikang;Tian Yang
58 Nitric oxide prodrug delivery and release monitoring based on galactose-modified multifunctional nanoprobe 期刊论文 Dang Yijing;Ruan Liting;Tian Yang;Xu Zhiai;Zhang Wen
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