结核分枝杆菌的DNA复制调控网络及其与耐药性突变偶联的遗传机制研究

30930003
2009
C0103.微生物组学与代谢
何正国
重点项目
教授
华中农业大学
180万元
耐药性;蛋白质互作网络;结核分枝杆菌;DNA复制调控;药靶
2010-01-01到2013-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 ClpR Protein-like Regulator Specifically Recognizes RecA Protein-independent Promoter Motif and Broadly Regulates Expression of DNA Damage-inducible Genes in Mycobacteria 期刊论文 Wang, Yi|Huang, Yuanxia|Xue, Chaolun|He, Yang|He, Zheng-Guo|
2 Over-producing soluble protein complex and validating protein-protein interaction through a new bacterial co-expression system 期刊论文 Zeng, Jumei|Zhang, Lei|Li, Yuqing|Wang, Yi|Wang, Mingchao|Duan, Xin|He, Zheng-Guo|
3 A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis 期刊论文 Yang, Min|Gao, Chunhui|Cui, Tao|An, Jingning|He, Zheng-Guo|
4 The Mycobacterial LysR-Type Regulator OxyS Responds to Oxidative Stress and Negatively Regulates Expression of the Catalase-Peroxidase Gene 期刊论文 Li, Yuqing|He, Zheng-Guo|
5 A Proteome-Scale Identification of Novel Antigenic Proteins in Mycobacterium tuberculosis toward Diagnostic and Vaccine Development 期刊论文 Li, Yuqing|Zeng, Jumei|Shi, Jianfang|Wang, Mingchao|Rao, Muding|Xue, Chaolun|Du, Yanli|He, Zheng-Guo|
6 A Copper-responsive Global Repressor Regulates Expression of Diverse Membrane-associated Transporters and Bacterial Drug Resistance in Mycobacteria 期刊论文 Rao, Muding|Liu,Huicong|He, Zheng-Guo|
7 Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I 期刊论文 Huang, Feng|He, Zheng-Guo|
8 Global Protein-Protein Interaction Network in the Human Pathogen Mycobacterium tuberculosis H37Rv 期刊论文 He, Zheng-Guo|Cui, Tao|Zhang, Cong|Yang, Mm|Huang, Yuanxia|Li, Weihui|Zhang, Lei|Gao, Chunhui|He, Yang|
9 Radiation-sensitive gene A (RadA) targets DisA, DNA integrity scanning protein A, to negatively affect cyclic Di-AMP synthesis activity in Mycobacterium smegmatis. 期刊论文 Zhang, Lei|He, Zheng-Guo|
10 Characterization of a functional C-terminus of the Mycobacterium tuberculosis MtrA responsible for both DNA binding and interaction with its two-component partner protein, MtrB 期刊论文 Li, Yuqing|Zeng, Jumei|He, Zheng-Guo|
11 The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis. 期刊论文 Li,Yuqing|He,Zheng-Guo|
12 Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. 期刊论文 Yang, Min|Gao,Chunhui|Wang,Yi|Zhang,Hua|He,Zheng-Guo|
13 LtmA, a novel cyclic di-GMP-responsive activator, broadly regulates the expression of lipid transport and metabolism genes in Mycobacterium smegmatis 期刊论文 Li, Weihui|He, Zheng-Guo|
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